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Koloda Iu.A.

Kafedra akusherstva i ginekologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Anshina M.B.

Tsentr reproduktsii i genetiki "FertiMed", Moskva

The use of estradiol hemihydrate transdermal gel in frozen embryo transfer cycles (an open multicenter non-intervention study)

Authors:

Koloda Iu.A., Anshina M.B.

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Journal: Russian Journal of Human Reproduction. 2019;25(6): 51‑57

DOI: 10.17116/repro20192506151

Read: 5413 times

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THE USE OF ESTRADIOL HEMIHYDRATE TRANSDERMAL GEL IN FROZEN EMBRYO TRANSFER CYCLES (AN OPEN MULTICENTER NON-INTERVENTION STUDY)
THE USE OF ESTRADIOL HEMIHYDRATE TRANSDERMAL GEL IN FROZEN EMBRYO TRANSFER CYCLES (AN OPEN MULTICENTER NON-INTERVENTION STUDY)

To cite this article:

Koloda IuA, Anshina MB. The use of estradiol hemihydrate transdermal gel in frozen embryo transfer cycles (an open multicenter non-intervention study). Russian Journal of Human Reproduction. 2019;25(6):51‑57. (In Russ.)
https://doi.org/10.17116/repro20192506151

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective — to assess the dynamics of the endometrial thickness with estradiol hemihydrate used for preparation of the endometrium for frozen embryo transfer (FET) cycles. Material and methods: In this open multicenter non-intervention study, 207 women undergoing FET cycles were enrolled. All patients were treated with transdermal oestrogel gel (estradiol hemihydrate). The recommended range of therapeutic doses was 1,5—3 mg of estradiol. Results: The duration of endometrial preparation before FET was 16.6 ± 0.15 days. The mean endometrial thickness at day of embryo transfer was 9,6±1,2 mm. Estradiol hemihydrate provided optimal endometrial thickness of more than 8 mm in 98% of all FET cycles. 1.4% of patients had mild adverse events. No serious adverse events were observed. Conclusion: The use of the transdermal form of estrogen in the form of estradiol hemihydrate provides high efficiency and safety in preparing the endometrium for FET.

Keywords:

assisted reproductive technologies
frozen embryo transfer cycle
estradiol hemihydrate

Authors:

Koloda Iu.A.

Kafedra akusherstva i ginekologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Anshina M.B.

Tsentr reproduktsii i genetiki "FertiMed", Moskva

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