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Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russia, Yekaterinburg, Russia

Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

Mikhelson A.A.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Okulova E.O.

Ural Research Institute of Maternal and Infant Care, Yekaterinburg, Russia

The role of environmental factors in the pathogenesis of infertility associated with genital endometriosis (literature review)

Authors:

Bashmakova N.V., Melkozerova O.A., Mikhelson A.A., Okulova E.O.

More about the authors

Journal: Russian Journal of Human Reproduction. 2019;25(5): 42‑48

DOI: 10.17116/repro20192505142

Read: 2155 times

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Table of contents

THE ROLE OF ENVIRONMENTAL FACTORS IN THE PATHOGENESIS OF INFERTILITY ASSOCIATED WITH GENITAL ENDOMETRIOSIS (LITERATURE REVIEW)
THE ROLE OF ENVIRONMENTAL FACTORS IN THE PATHOGENESIS OF INFERTILITY ASSOCIATED WITH GENITAL ENDOMETRIOSIS (LITERATURE REVIEW)

To cite this article:

Bashmakova NV, Melkozerova OA, Mikhelson AA, Okulova EO. The role of environmental factors in the pathogenesis of infertility associated with genital endometriosis (literature review). Russian Journal of Human Reproduction. 2019;25(5):42‑48. (In Russ.)
https://doi.org/10.17116/repro20192505142

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review analyzes a literature database, including systematic reviews and randomized clinical studies on the role of environmental factors in the pathogenesis of infertility associated with genital endometriosis. Publications of pubmed, medline, crossref databases in the interval 2012—2019 have been analyzed. The review demonstrates the role of the theory of epithelial-mesenchymal transition in the progression of genital endometriosis. The latest studies on the effect of oxidative stress and immune dysfunction accompanying endometriosis on the fertility of women are presented.

Keywords:

genital endometriosis
infertility
oxidative stress
immune dysfunction
epithelial-mesenchymal transition

Authors:

Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russia, Yekaterinburg, Russia

Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

Mikhelson A.A.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Okulova E.O.

Ural Research Institute of Maternal and Infant Care, Yekaterinburg, Russia

Close metadata

References:

  1. Adamyan LV, Andreeva EN, Apolikhina IA, Bezhenar VF, Gevorkyan MA, Gus AI, Demidov VN, Kalinina EA, Levakov SA, Marchenko LA, Popov AA, Sonova MM, Khashukoyeva AZ, Chernukha GE, Yarotskaya EL. Ehndometrioz: diagnostika, lechenie i reabilitaciya. Federal’nye klinicheskie rekomendacii po vedeniyu bol’nyh. M.: Rossiĭskoe obshchestvo akusherov-ginekologov; 2013. (In Russ.)
  2. Pshenichnyuk EYu, Asaturova AV, Adamyan LV, Zaitsev NV. Immunohistochemical features of eutopic and ectopic endometria in patients with a relapsing course of endometrioid ovarian cysts. Akusherstvo i ginekologya. 2018;3:84-95. (In Russ.) https://doi.org/10.18565/aig.2018.3.84-95
  3. Yang YM, Yang WX. Epithelial-to-mesenchymal transition in the development of endometriosis. Oncotarget. 2017;8(25):41679-41689. https://doi.org/10.18632/oncotarget.16472
  4. Bartley J, Jülicher A, Hotz B, Mechsner S, Hotz H. Epithelial to mesenchymal transition (EMT) seems to be regulated differently in endometriosis and the endometrium. Archives of Gynecology and Obstetrics. 2014;289(4):871-881. https://doi.org/10.1007/s00404-013-3040-4
  5. Proestling K, Birner P, Gamperl S, Nirtl N, Marton E, Yerlikaya G, Wenzl R, Streubel B, Husslein H. Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis. Reproductive Biology and Endocrinology. 2015;13(22):75. https://doi.org/10.1186/s12958-015-0063-7
  6. Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L. Oxidative Stress and Endometriosis: A Systematic Review of the Literature. 2017;2017:7265238. https://doi.org/10.1155/2017/7265238
  7. Nasiri N, Moini A, Eftekhari-Yazdi P, Karimian L, Salman-Yazdi R, Arabipoor A. Oxidative stress statues in serum and follicular fluid of women with endometriosis. Cell Journal. 2017;18(4):582-587. https://doi.org/10.22074/cellj.2016.4724
  8. Bragatto FB, Barbosa CP, Christofolini DM, Peluso C, dos Santos AA, Mafra FA, Cavalcanti V, Hix S, Bianco B. There is no relationship between paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study. Reproductive Health. 2013;10:32. https://doi.org/10.1186/1742-4755-10-32
  9. Prieto L, Quesada JF, Cambero O, Pacheco A, Pellicer A, Codoceo R, Garcia-Velasco JA. Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis. Fertility and Sterility. 2012;98(1):126-130. https://doi.org/10.1016/j.fertnstert.2012.03.052
  10. Turkyilmaz E, Yildirim M, Cendek BD, Baran P, Alisik M, Dalgaci F, Yavuz AF. Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2016;199:164-168. https://doi.org/10.1016/j.ejogrb.2016.02.027
  11. Santulli P, Chouzenoux S, Fiorese M, Marcellin L, Lemarechal H, Millischer AE, Batteux F, Borderie D, Chapron C. Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased. Human Reproduction. 2015;30(1):49-60. https://doi.org/10.1093/humrep/deu290
  12. Nakagawa K, Hisano M, Sugiyama R, Yamaguchi K. Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma. Archives of Gynecology and Obstetrics. 2016;293(1):197-202. https://doi.org/10.1007/s00404-015-3834-7
  13. Da Broi MG, Jordão AA Jr, Ferriani RA1,3, Navarro PA. Oocyte oxidative DNA damage may be involved in minimal/mild endometriosis-related infertility. Molecular Reproduction and Development. 2018;85(2):128-136. https://doi.org/10.1007/s00404-015-3834-710.1002/mrd.22943
  14. Goud PT, Goud AP, Joshi N, Puscheck E, Diamond MP, Abu-Soud HM. Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis. Fertility and Sterility. 2014;102(1):151-159. https://doi.org/10.1016/j.fertnstert.2014.03.053
  15. Máté G, Bernstein LR, Török AL. Endometriosis is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis? Frontiers in Endocrinology. 2018;9:725. https://doi.org/10.3389/fendo.2018.00725
  16. Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y. The root of reduced fertility in aged women and possible therapentic options: current status and future perspects. Molecular Aspects of Medicine. 2014;38:54-85. https://doi.org/10.1016/j.mam.2013.06.001
  17. Sharma RK, Azeem A, Agarwal A. Spindle and chromosomal alterations in metaphase II oocytes. Reproductive Sciences. 2013;20:1293-1301. https://doi.org/110.1177/1933719113483018
  18. Perkins AT, Das TM, Panzera LC, Bickel SE. Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(44):E6823-E6830. https://doi.org/10.1073/pnas.1612047113
  19. Li YJ, Han Z, Ge L, Zhou CJ, Zhao YF, Wang DH. C-phycocyanin protects against low fertility by inhibiting reactive oxygen species in aging mice. Oncotarget. 2016;7:17393-17409. https://doi.org/10.18632/oncotarget.8165
  20. Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L. Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Human Reproduction. 2012;27(5):1411-1420. https://doi.org/10.1093/humrep/des019
  21. Mihalas BP, De Iuiis GN, Redgrove KA, McLaughlin EA, Nixon B. The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte. Scientific Reports. 2017;7:6247. https://doi.org/10.1038/s41598-017-06372-z
  22. Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL. Resveratrol protects against age-associated infertility in mice. Human Reproduction. 2013;28:707-717. https://doi.org/10.1093/humrep/des437
  23. Liang LF, Qi ST, Xian YX, Huang L, Sun XF, Wang WH. Protective effect of antioxidants on the pre-maturation aging of mouse oocytes. Scientific Reports. 2017;7:1434. https://doi.org/10.1038/s41598-017-01609-3
  24. Silva E, Greene AF, Strauss K, Herrick JR, Schoolcraft WB, Krisher RL. Antioxidant supplementation during in vitro culture improves mitochondrial function and development of embryos from aged female mice. Reproduction Fertility and Development. 2015;27:975-983. https://doi.org/10.1071/RD14474
  25. He C, Wang J, Zhang Z, Yang M, Li Y, Tian X. Mitochondria synthesize melatonin to ameliorate its function and improve mice oocyte’s quality under in vitro conditions. International Journal of Molecular Sciences. 2016;17:939. https://doi.org/10.3390/ijms17060939
  26. Haghighian HK, Haidari F, Mohammadi-Asl J, Dadfar M. Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men. Fertility and Sterility. 2015;104:318-324. https://doi.org/10.1016/j.fertnstert.2015.05.014
  27. Qian D, Li Z, Zhang Y, Huang Y, Wu Q, Ru G. Response of mouse zygotes treated with mild hydrogen peroxide as a model to reveal novel mechanisms of oxidative stress-induced injury in early embryos. Oxidative Medicine and Cellular Longevity. 2016:1521428. https://doi.org/10.1155/2016/1521428
  28. Zhang Y, Qian D, Li Z, Huang Y, Wu Q, Ru G. Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2. Cell Stress and Chaperones. 2016;21:687-696. https://doi.org/10.1007/s12192-016-0693-5
  29. Miller JE, Ahn SH, Monsanto SP, Khalaj K, Koti M, Tayade C. Implications of immune dysfunction on endometriosis associated infertility. Oncotarget. 2017;8(4):7138-7147. https://doi.org/10.18632/oncotarget
  30. Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, Lessey BA, Tayade C. Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients. Fertility and Sterility. 2016;105(4):968-977. https://doi.org/10.1016/j.fertnstert.2015.11.047
  31. Ahn SH, Khalaj K, Young SL, Lessey BA, Koti M, Tayade C. Immune-inflammation gene signatures in endometriosis patients. Fertility and Sterility. 2016;106(6):1420-1431. https://doi.org/10.1016/j.fertnstert.2016.07.005
  32. Giuliani E, Parkin KL, Lessey BA, Young SL, Fazleabas AT. Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis. American Journal of Reproductive Immunology. 2014;72(3):262-269. https://doi.org/10.1111/aji.12259
  33. Thiruchelvam U, Wingfield M, O’Farrelly C. Increased uNK Progenitor Cells in Women with Endometriosis and Infertility are Associated with Low Levels of Endometrial Stem Cell Factor. American Journal of Reproductive Immunology. 2016;75(4):493-502. https://doi.org/10.1111/aji.12486
  34. Young VJ, Brown JK, Saunders PT, Duncan WC, Horne AW. The peritoneum is both a source and target of TGF-β in women with endometriosis. PLoS One. 2014;9(9):106773. https://doi.org/10.1371/journal.pone.0106773
  35. McGuane JT, Watson KM, Zhang J, Johan MZ, Wang Z, Kuo G, Sharkey DJ, Robertson SA, Hull ML. Seminal Plasma Promotes Lesion Development in a Xenograft Model of Endometriosis. The American Journal of Pathology. 2015;185(5):1409-1422. https://doi.org/10.1016/j.ajpath.2015.01.010
  36. Ibrahim MG, Elghonaimy EA, Schäfer S, Vennemann M, Kliesch S, Kiesel L, Götte M, Schüring AN. Seminal plasma (SP) induces a rapid transforming growth factor beta1 (TGFβ1)-independent up-regulation of epithelial-mesenchymal transdifferentiation (EMT) and myofibroblastic metaplasia-markers in endometriotic (EM) and endometrial cells. Archives of Gynecology and Obstetrics. 2019;299(1):173-183. https://doi.org/10.1007/s00404-018-4965-4
  37. Singh AK, Dutta M, Chattopadhyay R, Chakravarty B, Chaudhury K. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis. Journal of Assisted Reproduction and Genetics. 2016;33(10):1363-1372. https://doi.org/10.1007/s10815-016-0782-5
  38. Jianini BTGM, Giorgi VSI, Da Broi MG, de Paz CCP, Rosa E Silva JC, Ferriani RA, Navarro PA. Peritoneal Fluid From Infertile Women With Minimal/Mild Endometriosis Compromises the Meiotic Spindle of Metaphase II Bovine Oocytes: A Pilot Study. Reproductive Sciences. 2017;24(9):1304-1311. https://doi.org/10.1177/1933719116687658
  39. Heitmann RJ, Tobler KJ, Gillette L, Tercero J, Burney RO. Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model. Journal of Assisted Reproduction and Genetics. 2015;32(9):1317-1323. https://doi.org/10.1007/s10815-015-0516-0
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