The pathogenesis of the damaging effects of hyperglycemia is associated with the initiation of polyol pathway of glucose metabolism, accumulation in tissues of early and end products glycation (AGE), activation of protein kinase C. Advanced glycation end products (AGE) are products of non-enzymatic glycation and protein oxidation. Interest in studying the role of AGE in reproduction has been growing over the past few years. Patological processes of glycation lead to irreversible cross-binding of protein, loss of protein structure and function, followed by cell apoptosis. The excessive accumulation of protein glycation products adversely affects the processes of folliculogenesis in the ovaries. Advanced glycation end products participate in inhibition of cell proliferation reinforce the apoptosis of granulosa cells. The potential accumulation of AGE in ovarian tissue is associated with the activation of the oxidative stress reaction. The soluble receptor for AGE (sRAGE) binds the circulating toxic AGE outside the cell, preventing the adverse intracellular action of AGE in all organs, including the ovaries. The level of soluble receptor for AGE (sRAGE) in follicular fluid is an important biological marker characterizing the ovarian reserve. The binding of the soluble receptor for AGE to the end products of glycation outside the cell, prevents the adverse effects of AGE on the intracellular processes of the growing follicle. In the correction of violations caused by the excessive accumulation of protein glycation products, it is assumed to use methods aimed at preventing the formation of AGE. The study of mechanisms of the effects of AGE on the female reproductive system is promising and may contribute to positive results in the treatment of polycystic ovary syndrome (PCOS), infertility, recurrent miscarriage and other gynecological diseases. The purpose of the work is the collection and analysis of literature data on the role of AGE in the regulation of female reproductive system.