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Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russian Federation, Yekaterinburg, Russia

Shchedrina I.D.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Endometrial stem cells: the clinical application (a review)

Authors:

Melkozerova O.A., Bashmakova N.V., Shchedrina I.D.

More about the authors

Journal: Russian Journal of Human Reproduction. 2018;24(5): 63‑71

DOI: 10.17116/repro20182405163

Read: 3329 times

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Table of contents

ENDOMETRIAL STEM CELLS: THE CLINICAL APPLICATION (A REVIEW)
ENDOMETRIAL STEM CELLS: THE CLINICAL APPLICATION (A REVIEW)

To cite this article:

Melkozerova OA, Bashmakova NV, Shchedrina ID. Endometrial stem cells: the clinical application (a review). Russian Journal of Human Reproduction. 2018;24(5):63‑71. (In Russ.)
https://doi.org/10.17116/repro20182405163

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review examines the identification, production, cultivation, clinical application of mesenchymal stem cells isolated from the endometrium in the animal model and in humans. The modern aspects of the etiology, epidemiology, diagnosis and treatment of Asherman’s syndrome are analyzed. The therapy traditionally use for this purpose is insufficient in some cases. One of the possible solutions of the problem is the autotransplantation of cultured mesenchymal stem cells isolated from the endometrium, which not only have the advantage of minimally invasive production, but also provide the best ability for decidual differentiation, so important for realizing the endometrial tissue response to pregnancy. In addition, endometrial mesenchymal stem cells have a number of paracrine effects, such as anti-inflammatory, immunomodulating and antifibrotic, which are so important for pathogenetic treatment of Ascherman’s syndrome and makes them even more promising substratum for use in the therapy of this syndrome.

Keywords:

Ascherman’s syndrome
endometrial mesenchymal stem cells
infertility
mesenchymal stem cells
cell therapy

Authors:

Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russian Federation, Yekaterinburg, Russia

Shchedrina I.D.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

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