Objective — to study the expression of receptors for vitamin D in endometrial cells in patients with preeclampsia. Material and methods. The subject of the study were pieces of endometrium measuring 1×0.5×0.5 cm, obtained from the edge of the surgical incision of the uterus during cesarean section. The material from 35 women with pre-eclampsia with a gestation period of 36—39 weeks was used, which was used to perform operative delivery by caesarean section. The control group consisted of 30 patients with scheduled operative delivery. The detection of vitamin D receptors in endometrial cells was performed by an indirect immunohistochemical method using polyclonal rabbit antibodies. By determining peroxidase using 3,3-diaminobenzidine (Sigma Chemical, USA), specific binding of antibodies was detected. As a result of this procedure, the color of the reaction product was found to be brown. As a control of the specificity of immunohistochemical staining, the same treatment was performed for the sections, but with normal rabbit serum at a final concentration of 1%. By visual determination, the results of the immunohistochemical staining intensity were measured with the Olympus CX-21 light microscope, the Olympus Camedia 4040z digital camera. Results. In patients with preeclampsia, the specific staining of endometrial cells to vitamin D receptors was light brown in 22 (62.9%) of 35 cases and was assessed as weak. In 8 (22.9%) cases, the staining of endometrial cells to vitamin D receptors was assessed as an average with a brown color. In 19 (63.3%) patients with a physiological pregnancy, staining of endometrial cell nuclei to vitamin D receptors was brown and regarded as an average. In the remaining 7 (23.3%) cases, the staining of the endometrial cell nuclei to vitamin D receptors was dark brown and evaluated as a strong. Conclusions. Expression of vitamin D receptors in endometrial cells in patients with preeclampsia is significantly reduced, which is probably one of the reasons for the incomplete invasion of trophoblast, and further causes the development of preeclampsia.