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Kurbanova K.K.

V.I. Razumovsky Saratov State Medical University

Kovaleva A.A.

V.I. Vernadsky Crimean Federal University

Akopyan A.V.

V.I. Razumovsky Saratov State Medical University

Rak D.M.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Shuliakova A.S.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Clinical efficacy of vitamin D in the prevention of osteoporosis and fractures in elderly patients

Authors:

Kurbanova K.K., Kovaleva A.A., Akopyan A.V., Rak D.M., Shuliakova A.S.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(5): 103‑110

DOI: 10.17116/profmed202528051103

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Table of contents

CLINICAL EFFICACY OF VITAMIN D IN THE PREVENTION OF OSTEOPOROSIS AND FRACTURES IN ELDERLY PATIENTS
CLINICAL EFFICACY OF VITAMIN D IN THE PREVENTION OF OSTEOPOROSIS AND FRACTURES IN ELDERLY PATIENTS

To cite this article:

Kurbanova KK, Kovaleva AA, Akopyan AV, Rak DM, Shuliakova AS. Clinical efficacy of vitamin D in the prevention of osteoporosis and fractures in elderly patients. Russian Journal of Preventive Medicine. 2025;28(5):103‑110. (In Russ.)
https://doi.org/10.17116/profmed202528051103

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Osteoporosis leads to reduced bone mineral density (BMD) and increased risk of osteoporotic fractures in elderly patients, that makes it an urgent sociomedical problem. Vitamin D deficiency plays a leading role in the development of these conditions, affecting calcium-phosphorus and bone metabolisms. Despite numerous studies, the effectiveness of vitamin D in preventing osteoporosis and fractures remains a matter of scientific debates.

OBJECTIVE

To assess the clinical effectiveness of vitamin D in osteoporosis and fractures prevention in elderly patients according to the literature data.

MATERIALS AND METHODS

A review of scientific works published between 2018 and 2024 has been carried out. The PubMed, Scopus, Web of Science, eLIBRARY and KiberLeninka databases have been used. Descriptions of studies and meta-analyses assessing the impact of vitamin D on BMD, risk of osteoporotic fractures and treatment safety in elderly patients are included. Publications with small sample size and low evidence level are excluded.

RESULTS

The analysis has shown that therapy with vitamin D is primarily effective for preventing osteoporosis in patients with 25-hydroxycholecalciferol (25(OH)D) deficiency (<20 ng/ml) and contributes to reducing the risk of fractures. The therapeutic effect was minimal in persons with normal vitamin D level. Issues on vitamin D high doses safety, including the risk of hypercalcemia and hypervitaminosis D, have been considered.

CONCLUSIONS

The clinical effectiveness of vitamin D in osteoporosis prevention has been confirmed in elderly patients with severe 25(OH)D deficiency. An individualized approach to therapy, including regular monitoring of 25(OH)D level, is recommended to achieve optimal results. Further research is needed to develop optimal vitamin D dosing schemes and refine its combined application with other treatment methods.

Keywords:

vitamin D
osteoporosis
bone mineral density
elderly patients
osteoporotic fractures
vitamin D deficiency
hypercalcemia

Authors:

Kurbanova K.K.

V.I. Razumovsky Saratov State Medical University

Kovaleva A.A.

V.I. Vernadsky Crimean Federal University

Akopyan A.V.

V.I. Razumovsky Saratov State Medical University

Rak D.M.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Shuliakova A.S.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Received:

17.01.2025

Accepted:

27.02.2025

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References:

  1. Ludan VV, Polskaya LV. Prevention of osteoporosis. Tavricheskii mediko-biologicheskii vestnik. 2020;23(4):98-104. (In Russ.).
  2. Muñoz M, Robinson K, Shibli-Rahhal A. Bone health and osteoporosis prevention and treatment. Clinical Obstetrics and Gynecology. 2020;63(4):770-787.  https://doi.org/10.1097/GRF.0000000000000572
  3. Xiao PL, Cui AY, Hsu CJ, et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporosis International. 2022;33(10):2137-2153. https://doi.org/10.1007/s00198-022-06454-3
  4. Johnston CB, Dagar M. Osteoporosis in older adults. Medical Clinics of North America. 2020;104(5):873-884.  https://doi.org/10.1016/j.mcna.2020.06.004
  5. Aspray TJ, Hill TR. Osteoporosis and the ageing skeleton. Sub-cellular biochemistry. 2019;91:453-476.  https://doi.org/10.1007/978-981-13-3681-2_16
  6. Chang SW, Lee HC. Vitamin D and health — The missing vitamin in humans. Pediatrics and Neonatology. 2019;60(3):237-244.  https://doi.org/10.1016/j.pedneo.2019.04.007
  7. Dzhatdoeva DT, Gochiyaev AA, Semenov MB, Kappusheva ZM. The biological role of vitamin D. Vestnik KazNMU. 2021;(2):168-171. (In Russ.).
  8. Chevalley T, Brandi ML, Cashman KD, et al. Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clinical and Experimental Research. 2022;34(11):2603-2623. https://doi.org/10.1007/s40520-022-02279-6
  9. Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European Journal of Clinical Nutrition. 2020;74(11):1498-1513. https://doi.org/10.1038/s41430-020-0558-y
  10. Yu B, Wang CY. Osteoporosis and periodontal diseases–An update on their association and mechanistic links. Periodontology 2000. 2022;89(1):99-113.  https://doi.org/10.1111/prd.12422
  11. Lin YJ, Liang WM, Chiou JS, et al. Genetic predisposition to bone mineral density and their health conditions in East Asians. Journal of Bone and Mineral Research. 2024;39(7):929-941.  https://doi.org/10.1093/jbmr/zjae078
  12. Wang J, Shu B, Li CG, et al. Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China. BMJ Open. 2019;9(11):e028084. https://doi.org/10.1136/bmjopen-2018-028084
  13. Cannarella R, Barbagallo F, Condorelli RA, et al. Osteoporosis from an endocrine perspective: the role of hormonal changes in the elderly. Journal of Clinical Medicine. 2019;8(10):1564. https://doi.org/10.3390/jcm8101564
  14. Rosen HN. Calcium and vitamin D supplementation in osteoporosis. UpToDate; 2024. Accessed December 16,2024. https://www.uptodate.com/contents/calcium-and-vitamin-d-supplementation-in-osteoporosis
  15. Eckstrom E, Neukam S, Kalin L, et al. Physical activity and healthy aging. Clinics in Geriatric Medicine. 2020;36(4):671-683.  https://doi.org/10.1016/j.cger.2020.06.009
  16. Adejuyigbe B, Kallini J, Chiou D, et al. Osteoporosis: molecular pathology, diagnostics, and therapeutics. International Journal of Molecular Sciences. 2023;24(19):14583. https://doi.org/10.3390/ijms241914583
  17. LeBoff MS, Chou SH, Murata EM, et al. Effects of supplemental vitamin D on bone health outcomes in women and men in the VITamin D and OmegA-3 TriaL (VITAL). Journal of Bone and Mineral Research. 2020;35(5): 883-893.  https://doi.org/10.1002/jbmr.3958
  18. Pajor K, Szpyt J, Lubkowska A. Effect of vitamin D supplementation on bone mineral density in people with low risk of osteoporosis. Journal of Education, Health and Sport. 2019;9(9):1162-1174. https://doi.org/10.5281/zenodo.3464905
  19. Kong SH, Jang HN, Kim JH, et al. Effect of vitamin D supplementation on risk of fractures and falls according to dosage and interval: a meta-analysis. Endocrinology and Metabolism. 2022;37(2):344-358.  https://doi.org/10.3803/EnM.2021.1374
  20. Yakabe M, Hosoi T, Matsumoto S, et al. Prescription of vitamin D was associated with a lower incidence of hip fractures. Scientific Reports. 2023; 13:12889. https://doi.org/10.1038/s41598-023-40259-6
  21. Ko S, Jun C, Nam J. Effects of vitamin D supplementation on the functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency. Journal of Orthopaedic Surgery and Research. 2021; 16(1):571.  https://doi.org/10.1186/s13018-021-02717-7
  22. Manaker L. New Guidelines highlight who should be getting more than the recommended vitamin D. Verywell Health. 2024. Accessed December 16,2024. https://www.verywellhealth.com/new-guidelines-supplemental-vitamin-d-8666125?utm_source
  23. Klinicheskie rekomendacii Endocrine Society po profilakticheskomu primeneniyu vitamina D. E`NDOSFERA; 2024. Accessed December 16,2024. (In Russ.). https://edu.endocrincentr.ru/novosti/klinicheskie-rekomendacii-endocrine-society-po-profilakticheskomu-primeneniyu-vitamina-d?utm_source
  24. Belaya ZhE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4-47. (In Russ.). https://doi.org/10.14341/osteo12930
  25. Burt LA, Billington EO, Rose MS, et al. Effect of high-dose vitamin D supplementation on volumetric bone density and bone strength: a randomized clinical trial. JAMA. 2019;322(19):1925. https://doi.org/10.1001/jama.2019.11889
  26. Burt LA, Billington EO, Rose MS, et al. Adverse effects of high-dose vitamin D supplementation on volumetric bone density are greater in females than males. Journal of Bone and Mineral Research. 2020;35(12):2404-2414. https://doi.org/10.1002/jbmr.4152
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