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Duboshinskij R.I.

Tyumen State Medical University

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

Doyan Yu.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Features of depressive disorders and suicidal behavior in multiple sclerosis

Authors:

Duboshinskij R.I., Kicherova O.A., Reikhert L.I., Doyan Yu.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(9): 7‑13

DOI: 10.17116/jnevro20251250917

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Table of contents

FEATURES OF DEPRESSIVE DISORDERS AND SUICIDAL BEHAVIOR IN MULTIPLE SCLEROSIS
FEATURES OF DEPRESSIVE DISORDERS AND SUICIDAL BEHAVIOR IN MULTIPLE SCLEROSIS

To cite this article:

Duboshinskij RI, Kicherova OA, Reikhert LI, Doyan YuI. Features of depressive disorders and suicidal behavior in multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(9):7‑13. (In Russ.)
https://doi.org/10.17116/jnevro20251250917

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

OBJECTIVE

The aim of the literature review was to analyze the epidemiological features, pathogenetic relationships and pathomorphological changes that determine the high incidence of depressive disorders in the population of patients with multiple sclerosis.

MATERIAL AND METHODS

The analysis of the literature presented in the aggregator databases was carried out: PubMed, Google Scholar, CyberLeninka, eLIBRARY. The review includes the results of studies, meta-analyses, systematic reviews of scientific literature. For the search, queries were formed with the following keywords: «depression», «suicide», «multiple sclerosis», «quality of life».

RESULTS

It was found that the high prevalence of depressive disorders in patients with multiple sclerosis is due to the commonality of individual links in the pathogenesis of these pathological conditions. In multiple sclerosis, as well as in depressive disorders, there is stigmatization, misunderstanding from others, colleagues and relatives. Pathogenetic aspects of comorbidity are caused by disruption of the serotonergic and dopaminergic systems of the brain, neuroinflammatory processes, and vitamin D deficiency. The presence of multiple sclerosis creates the preconditions for the development of symptoms of depression, which, in turn, cause an increase in the severity and rate of its progression, trapping the patient in a vicious circle in which both diseases mutually reinforce each other.

CONCLUSION

Raising awareness of depressive disorders in MS, individualized treatment approaches, and improving the quality of social, psychological, and pharmacological care for individuals suffering from this serious illness will help develop an effective care system for this category of patients.

Keywords:

Multiple sclerosis
suicide
depression
vitamin D
suicidal behavior
comorbidity

Authors:

Duboshinskij R.I.

Tyumen State Medical University

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

Doyan Yu.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Received:

27.09.2024

Accepted:

27.12.2024

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