The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kalinchenko S.Iu.

Kafedra ndokrinologii Rossiĭskogo universiteta druzhby narodov, Moskva

Zhilenko M.I.

Clinic of professor Kalinchenko

Gusakova D.A.

N.A. Lopatkin Research Institute of Urology — affiliated branch of federal state budgetary institution «P.A. Gertsen Federal Medical Research Centre», Russian Ministry of Health

Tjuzikov I.A.

Mskhalaia G.Zh.

Klinika reproduktivnoĭ meditsiny MAMA, Moskva

Sablin K.S.

Clinic of Reproduction «Mama»

Dymova A.V.

I.M. Sechenov First Moscow State Medical University, 119991

Vitamin D and reproductive health of women

Authors:

Kalinchenko S.Iu., Zhilenko M.I., Gusakova D.A., Tjuzikov I.A., Mskhalaia G.Zh., Sablin K.S., Dymova A.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2016;22(4): 28‑36

DOI: 10.17116/repro201622428-36

Read: 23953 times

Download PDF (RU)
Contact the author
Table of contents

VITAMIN D AND REPRODUCTIVE HEALTH OF WOMEN
VITAMIN D AND REPRODUCTIVE HEALTH OF WOMEN

To cite this article:

Kalinchenko SIu, Zhilenko MI, Gusakova DA, Tjuzikov IA, Mskhalaia GZh, Sablin KS, Dymova AV. Vitamin D and reproductive health of women. Russian Journal of Human Reproduction. 2016;22(4):28‑36. (In Russ.)
https://doi.org/10.17116/repro201622428-36

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Comparative analysis of the resu­lts of treatment of gastric polyps by methods of loop electroexcision, laser and endo­scopic poly­pectomy with aspi­ration capture. Endo­scopic Surgery. 2024;(6):24-30
Asso­ciation between the vita­min D level and depression in the elde­rly people in the Euro­pean North of Russia. Russian Journal of Preventive Medi­cine. 2024;(12):107-113
Black Acanthosis: Diagnosis and Treatment Issues. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(6):709-712
Clinical and epidemiological indi­cators of stroke during the COVID-19 pandemic and in the post-COVID period in the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):5-11
Resu­lts of the All-Russian consensus conference on complications in bariatric surgery. Endo­scopic Surgery. 2025;(1):15-24
Vita­min D role in oral cavity diseases. Stomatology. 2025;(1):81-86
Combined treatment of patients with acute muscular tonic syndrome with dorsopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):70-77
Characteristics, treatment features and in-hospital mortality of patients with myocardial infa­rction over 75 years old in Russia acco­rding to the REGION-IM regi­stry. Russian Cardiology Bulletin. 2025;(1):22-38
Pharmacological treatment and prevention of ischemia-reperfusion syndrome in percutaneous coro­nary inte­rvention. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(2):191-200
Influence of griseofulvin on inte­stinal microbiota in the treatment of microsporia in rural children. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):185-190
Abstract:

Currently, the vitamin D deficiency is pandemic. The impact of vitamin D on reproductive function both in men and women is proven. In this regard, the modern correction of vitamin D deficiency plays a significant role in solving reproductive problems. The review is devoted to the problem of correction of vitamin D levels in different population groups. The results of a study in a large cohort of males and females performed at the "Clinic of Professor Kalinchenko" (Moscow) confirmed a low vitamin D level in the adult population. Therefore, correction of vitamin D deficiency is not exclusively a pediatric problem. Many diseases in the middle and old age populations are directly associated with vitamin D deficiency.

Keywords:

vitamin D
hypovitaminosis
reproductive system
treatment

Authors:

Kalinchenko S.Iu.

Kafedra ndokrinologii Rossiĭskogo universiteta druzhby narodov, Moskva

Zhilenko M.I.

Clinic of professor Kalinchenko

Gusakova D.A.

N.A. Lopatkin Research Institute of Urology — affiliated branch of federal state budgetary institution «P.A. Gertsen Federal Medical Research Centre», Russian Ministry of Health

Tjuzikov I.A.

Mskhalaia G.Zh.

Klinika reproduktivnoĭ meditsiny MAMA, Moskva

Sablin K.S.

Clinic of Reproduction «Mama»

Dymova A.V.

I.M. Sechenov First Moscow State Medical University, 119991

Close metadata

References:

  1. Shwarts GY.Vitamin Di D-hormon. М.: Аnaharsis. 2005;152. (In Russ.).
  2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930.
  3. Holick MF. Vitamin D deficiency. New Eng J Med. 2007;357:266-281.
  4. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinol. 2000;141:1317-1324.
  5. Castro LC. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 2011;55(8):566-575.
  6. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiological Reviews. 1998;78:1193-1231.
  7. Jenster G, Spencer TE, Burcin MM, Tsai SY, Tsai MJ, O’Malley BW. Steroid receptor induction of gene transcription: a two-step model. PNAS. 1997;94:7879-7884.
  8. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews. 2008;29:720-726.
  9. Blomberg JM, Dissing S. Non-genomic effects of vitamin D in human spermatozoa. Steroids. 2012;77(10):903-909.
  10. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76-89.
  11. Pleshcheva AV, Pigarova ЕА, Dzeranova LK. Vitamin D andmetabolism: facts, myths and perceptions. Obesity and metabolism. 2012;2:33-42. (In Russ.).
  12. Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M, RECORD Trial Group. Cardio vascular disease and vitamin D supplementation: trial analysis, systematic review, and metaanalysis. Am J Clin Nutr. 2014;100(3):746-755.
  13. Wehr E, Pilz S, Schweighofer N, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009;161:575-582.
  14. Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol. 2014;810:106-119.
  15. Tomlinson PB, Joseph C, Angioi M. Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with metaanalysis. J Sci Med Sport. 2015;18(5):575-580.
  16. Haghsheno MA, Mellström D, Behre CJ, et al. Low 25-OH vitamin D is associated with benign prostatic hyperplasia. J Urol. 2013;190(2):608-614.
  17. Gandini S, Boniol M, Haukka J, et al. Metaanalysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer. 2011;128(6):1414-1424.
  18. Xu Y, Shao X, Yao Y, et al. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated metaanalysis. J Cancer Res Clin Oncol. 2014;140(9):1465-1477.
  19. Meyer HE, Robsahm TE, Bjørge T, et al. Vitamin D, season, and risk of prostate cancer: a nested case-control study within Norwegian health studies. Am J Clin Nutr. 2013;97(1):147-154.
  20. Xu Y, He B, Pan Y, et al. Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Tumour Biol. 2014;35(5):4153-4169.
  21. Palacios С, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 PtA:138-145.
  22. Tishova UA, Vorslov LO, Shchukov AU, Kalinchenko SU. The prevalence of hormone-Ddeficiency-(25ОНD3) with obese patients in Russia: a retrospective population-based study. Material VII International Congress ISSAM. М. 2013;78-79.
  23. Tuzikov IA. Hormon D-statusin men with andrological pathologies (pilot study). Material X International Congress «Men's health». Minsk. 2014;89-91. (In Russ.).
  24. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28.
  25. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality - a review of recent evidence. Autoimmun Rev. 2013;12(10):976-989.
  26. The Vitamin D Society. URL. http://www.vitamindsociety.org/benefits.php
  27. Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014;99(6):E1137-E1145.
  28. Buggio L, Roncella E, Somigliana E, Vercellini P. Vitamin D and benign gynaecological diseases: A critical analysis of the current evidence. Gynecol Endocrinol. 2015;16:1-5.
  29. Lerchbaum E, Rabe T. Vitamin D and female fertility. Curr Opin Obstet Gynecol. 2014;26(3):145-150.
  30. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol. 2012;166(5):765-778.
  31. Aquila S, Guido C, Middea E, et al. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reprod Biol Endocrinol. 2009;7:140.
  32. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: a narrative review. Int J Clin Pract. 2013;67(3):225-235.
  33. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol. 2013;177(5):420-430.
  34. Gysemans CA, Cardozo AK, Callewaert H, et al. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in non-obese diabetic mice. Endocrinology. 2005;146 (4):1956-1964.
  35. Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science. 1983;221:1181-1183.
  36. Lemire JM, Adams JS, Sakai R, Jordan SC. 1Alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest. 1984;74:657-661.
  37. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94:26-34.
  38. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterol. 2007;132:2169-2180.
  39. Lasco A, Catalano A, Benvenga S. Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: results of a randomized, double-blind, placebo-controlled study. Arch Intern Med. 2012;172(4):366-367.
  40. Mathieu C, Gysemans C. Vitamin D and diabetes. Av Diabetol. 2006;22(3):187-193.
  41. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000;47(4):383-391.
  42. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and metaanalysis. J Clin Endocrinol Metab. 2007;92:2017-2029.
  43. Nimptsch K, Platz EA, Willett WC, Giovannucci E. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf). 2012;77(1):106-112.
  44. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Amer J Clin Nutr. 2000;72:690-693.
  45. Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR. Vitamin D status and bone histomorphometry in gross obesity. Amer J Clinical Nutr. 1981;34:2359-2363.
  46. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, Kimmig R, Mann K, Janssen OE. Low serum 25-hydroxy vitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exper Clin Endocrinol Diab. 2006;114:577-583.
  47. Garbedian K, Boggild M, Moody J, Liu KE. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open. 2013;1(2):E77-E82.
  48. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101(2):447-452.
  49. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, Pal L. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010;94(4):1314-1319.
  50. Polyzos NP, Anckaert E, Guzman L, Schiettecatte J, Van Landuyt L, Camus M, Smitz J, Tournaye H. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod. 2014;29(9):2032-2040.
  51. Marova EI, Rodionova SS, Rozhinskaya LYa, Shwarts GY. Alfacalcidol (alpha D3) in the prevention and treatment of osteoporosis. Methodical recommendations. М. 1998;35. (In Russ.).
  52. Brown AJ, Dusso AS, Slatopolsky E.Vitamin D analogues for secondary hyperparathyroidism. Nephrol Dial Transplant. 2002;17Suppl 10:10-19.
  53. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77:204-210.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.