Background. Hypertensive disorders of pregnancy are complex and unresolved problems of modern obstetrics. The role of PGF in placental function has been extensively studied in recent years. Objectives. To evaluate the significance of PlGF in the genesis of placental insufficiency in hypertensive disorders of pregnancy. Method. This case control study was performed in 231 pregnant woman, 1st group consisted of 106 pregnant women with hypertensive disorders (basic group I), 2nd group consisted of 105 pregnant women with risk factors for preeclampsia at 20-24 weeks gestation (basic group II), there were 20 healthy pregnant women at the same gestational period in a control group. Results. We found that hypertensive disorders in pregnancy were associated with 4 fold PIGF decrease as compared to control group. Severity of hypertensive disorders was inversely associated with the level of PlGF in the blood in pregnant women. Patients with hypertensive disorders and placental insufficiency associated with intrauterine growth retardation had minimal PIGF concentrations. Blood levels of PlGF were prognostic for pre-eclampsia in a range within 50-100 pg/ml and for combination of fetal IUGR with pre-eclampsia were PlGF levels up to 50 pg/ml, for the risk factors - the most significant were obesity, multiple pregnancy and associated non-gynecological maternal disorders. Prognostic significance of PlGF levels in the blood for pre-eclampsia, placental insufficiency and IUGR fetus was 87.1 % and - 67.7% for gestational hypertension. Conclusion. PlGF could be used as a prognostic factor for placental insufficiency in hypertensive disorders during gestation.