THE IMMUNOLOGICAL THEORY OF PREECLAMPSIA (a review)

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The preeclampsia is one of the most common complications in pregnancy; however, there is still no consensus regarding the trigger of this pathology. The immunological theory as one of the most credible and popular theory of preeclampsia is presented.

Keywords:

preeclampsia

immunological theory

immunity in physiological pregnancy.

Authors:

Makarov O.V.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Volkova E.V.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Vinokurova I.N.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Dzhokhadze L.S.

Kafedra akusherstva i ginekologii lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

List of references:

Steegers E.A., von Dadelszen P., Duvekot J.J., Pijnenborg R. Pre-eclampsia. Lancet 2010; 376: 9741: 631-644.
Levchenko G.V., Zorina V.N., Bazhenova L.G., Zorina R.M., Zorin N.A. Nekotorye aspekty patogeneza preeklampsii u beremennykh. Ros vestn akush ginekol 2010; 3: 20-34.
Mahmoud F., Omu A., Abul H., El-Rayes S., Haines D. Lymphocyte subpopulations in pregnancy complicated by hypertension. J Obstet Gynaecol 2003; 23: 1: 20-26.
Alekseev L.P., Boldyreva M.N. Peresmotr predstavlenii o roli HLA-antigenov v fiziologii i patologii reproduktivnogo protsessa. Fiziologiya i patologiya immunnoi sistemy 2004; 8: 1: 44-50.
Khaitov R.M., Alekseev L.P. Prednaznachenie immunnoi sistemy: vypolnenie fiziologicheskikh funktsii, obespechivayushchikh geneticheskoe postoyanstvo vnutrennei sredy organizma. Fiziologiya i patologiya immunnoi sistemy 2004; 8: 8: 3-14.
Grzywacz M., Gorski B., Jakubowska A. et al. Association between HLA-G01018 allele pregnancy complications. J Reprod Immunol 2003; 58: 2: 162.
Kovats S., Main E., Librach C. HLA-G expressed in human trophoblast. Science 1990; 248: 220-223.
King A., Allan D.S., Bowen M. et al. HLA-E expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells. Eur J Immunol 2000; 30: 1623-1631.
O'Brien J., Dausset E.D., Carosella Ph. et al. HLA-G is a possible candidate gene in genetic susceptibility to preeclampsia. Tissue antigens. XIII International Congress of histocompatibility and immungenetics. Seattle WA (USA) 2002; Suppl 59: 62.
Sageshima N., Ishitani A., Omura M. et al. Lack of HLA-G expression on trophoblasts: a reexamination of preclamptic placenta. Tissue antigens. XIII International Congress of histocompatibility and immungenetics. Seattle WA (USA) 2002; 59: Suppl 2: 62.
Cooper M.A., Fehniger T.A., Saligiuri M.A. The biology of human natural killer-cell subset. Trends Immunol 2001; 22: 11: 633-640.
Guleria I., Sayegh M.H. Maternal acceptance of the fetus: true human tolerance. J Immunol 2007; 178: 3345-3351.
Dosiou C., Giudice L.C. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 2005; 26: 44-62.
Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2: 656.
Hu Y., Dutz J.P., MacCalman C.D., Yong P., Tan R., von Dadelszen P. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-{gamma}. J Immunol 2006; 177: 8522-8530.
Lash G.E., Otun H.A., Innes B.A., Kirkley M., De Oliveira L., Searle R.F., Robson S.C., Bulmer J.N. Interferon-{gamma} inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 2006; 20: 2512-2518.
Saito S., Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol 2003; 59: 161-173.
Chaouat G., Lédée-Bataille N., Zourbas S., Ostojic S., Dubanchet S., Martal J., Frydman R. Cytokines, implantation and early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy concept. Am J Reprod Immunol 2003; 50: 177-186.
Bates M.D., Quenby S., Takakuwa K., Johnson P.M., Vince G.S. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod 2002; 17: 2439-2444.
Peck A., Mellins E.D. Plasticity of T-cell phenotype and function: the T helper type 17 example. Immunology 2009; 129: 147-153.
Sakaguchi S. Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-352.
Akbar A.N., Vukmanovic-Stejic M., Taams L.S., Macallan D.C. The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol 2007; 7: 231-237.
Sargent I.L., Borzychowski A.M., Redman C.W.G. Immunoregulation in normal pregnancy and pre-eclampsia: an overview. Reprod Biomed Online 2006; 13: 680-686.
Santner-Nanan B., Peek M.J., Khanam R., Richarts L., Zhu E., Fazekas de St Groth B., Nanan R. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol 2009; 183: 7023-7030.
Khonina N.A., Pasman N.M., Ostanin A.A. i dr. Osobennosti produktsii tsitokinov pri fiziologicheskoi i oslozhnennoi beremennosti. Akush i gin 2006; 2: 11-15.
Le Bouteiller P., Piazzato N., Solier C. et al. HLA-G: control of placental local immunity and angiogenesis. J Reprod Immunol ELSEVIER 2003; 58: 2: 115.
Szereday L., Barakonyi A., Miko E. et al. Gamma/delta T cell subsets, NKG2A expression and apoptosis of Vdelta2 T cells in pregnant women with or without risk for premature pregnancy termination. J Reprod Immunol ELSEVIER 2003; 58: 2: 171.
Germain S.J., Sacks G.P., Sooranna S.R., Sargent I.L., Redman C.W. Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. J Immunol 2007; 178: 5949-5956.
Tarnowska-Madra U., Leibschang J., Kowalska B., Filipp E., Kozar A., Nimer A., Maciejewski T. Levels of immunoreactive cytokines in serum of women with preeclampsia or severe pregnancy hypertension. Ginekol Pol 2010; 81: 3: 192-196.
Sasaki Y., Sakai M., Miyazaki S., Higuma S., Shiozaki A., Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10: 347-353.
Somerset D.A., Zheng Y., Kilby M.D., Sansom D.M., Drayson M.T. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004; 112: 38-43.
Steinborn A., Haensch G.M., Mahnke K., Schmitt E., Toermer A., Meuer S., Sohn C. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia? Clin Immunol 2008; 129: 401-412.
Bujold E., Chaiworapongsa T., Romero R., Gervasi M.T., Espinoza J., Goncalves L.F., Berman S., Yoon B.H., Kim Y.M. Neonates born to pre-eclamptic mothers have a higher percentage of natural killer cells (CD3-/CD56+16+) in umbilical cord blood than those without pre-eclampsia. J Matern Fetal Neonatal Med 2003; 14: 5: 305-312.
Balderas Pena L.M., Vizcaino Magana C.V., Hernandez Higareda S. et al. Lymphocyte subsets and preeclampsia. Ginec Obstet Mex 2008; 76: 6: 327-335.
Cadden K.A., Walsh S.W. Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia. Hypertens Pregnancy 2008; 27: 4: 396-405.
Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942-949.
Yang Y., Huang C.T., Huang X., Pardoll D.M. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 2004; 5: 508-515.
Marin R., Mendez R., Pedrinaci S. et al. HLA-E expression in tumor cell lines. Eur J Immunogen 2002; 29: 2: 145.
Simon Grill, Corinne Rusterholz, Rosanna Zanetti-Dällenbach, Sevgi Tercanli, Wolfgang Holzgreve, Sinuhe Hahn, Olav Lapaire. Potential markers of preeclampsia - a review. Reprod Biol Endocrinol 2009; 7: 70.
LaMarca B., Wallace K., Granger J. Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia. Curr Opin Pharmacol 2011; 11: 2: 175-179.

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