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Shpakov A.O.

Laboratoriia molekuliarnoĭ éndokrinologii Instituta évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Derkach K.V.

Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, St.-Petersburg, Russia

Surkova E.V.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr MZ RF, Moskva

Bespalov A.I.

Endocrinology Research Centre, Moscow, Russia

Perspectives of application of intranasally administered insulin for correction of metabolic and hormonal disorders in diabetes mellitus and metabolic syndrome

Authors:

Shpakov A.O., Derkach K.V., Surkova E.V., Bespalov A.I.

More about the authors

Journal: Problems of Endocrinology. 2019;65(5): 389‑395

DOI: 10.14341/probl9960

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Table of contents

PERSPECTIVES OF APPLICATION OF INTRANASALLY ADMINISTERED INSULIN FOR CORRECTION OF METABOLIC AND HORMONAL DISORDERS IN DIABETES MELLITUS AND METABOLIC SYNDROME
PERSPECTIVES OF APPLICATION OF INTRANASALLY ADMINISTERED INSULIN FOR CORRECTION OF METABOLIC AND HORMONAL DISORDERS IN DIABETES MELLITUS AND METABOLIC SYNDROME

To cite this article:

Shpakov AO, Derkach KV, Surkova EV, Bespalov AI. Perspectives of application of intranasally administered insulin for correction of metabolic and hormonal disorders in diabetes mellitus and metabolic syndrome. Problems of Endocrinology. 2019;65(5):389‑395. (In Russ.)
https://doi.org/10.14341/probl9960

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Abstract:

In recent years, the possibility of using intranasally administered insulin to treat Alzheimer’s disease and other cognitive disorders has been widely studied. At the same time, the possibility of its use in the treatment of diabetes mellitus is practically not investigated, which is due to the insufficient study of the molecular mechanisms of its action on the hormonal and metabolic status of the organism. The review discusses literature data and the results of our own research on the role of insulin in the central regulation of energy homeostasis, as well as on the experience of using intranasally administered insulin to correct eating disorders and metabolic and hormonal dysfunctions developing under conditions of experimental diabetes mellitus and metabolic syndrome. In studies involving healthy volunteers, various effects of intranasally administered insulin were shown, including effects on cognitive function, eating behavior and weight loss, and the gender specificity of its action was found. In the course of numerous studies of intranasally administered insulin in animal models of diabetes mellitus, not only stabilization of carbohydrate homeostasis was shown, but also a positive effect in the form of restoration of the functional activity of insulin signaling pathways in the hypothalamus and other parts of the brain. We have presented and analyzed data on the systemic effects of intranasally administered insulin in rodents with experimental models of diabetes mellitus, as well as in healthy individuals.

Keywords:

Insulin
intranasal administration
diabetes mellitus
metabolic syndrome
brain
insulin resistance
energy metabolism
thyroid system

Authors:

Shpakov A.O.

Laboratoriia molekuliarnoĭ éndokrinologii Instituta évoliutsionnoĭ fiziologii i biokhimii im. I.M. Sechenova RAN, Sankt-Peterburg

Derkach K.V.

Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, St.-Petersburg, Russia

Surkova E.V.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr MZ RF, Moskva

Bespalov A.I.

Endocrinology Research Centre, Moscow, Russia

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References:

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