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Iukina M.Iu.
FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Nuralieva N.F.
Endocrinology Research Centre, Moscow, Russia
Troshina E.A.
Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Kuznetsov N.S.
Endocrinology Research Centrer
Platonova N.M.
Endocrinology Research Centre, Moscow, Russia
The hypoglicemic syndrome (insulinoma): topical, pathomorphological, and genetic diagnostics and treatment (review, part 2)
Journal: Problems of Endocrinology. 2017;63(5): 346‑355
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To cite this article:
Iukina MIu, Nuralieva NF, Troshina EA, Kuznetsov NS, Platonova NM. The hypoglicemic syndrome (insulinoma): topical, pathomorphological, and genetic diagnostics and treatment (review, part 2). Problems of Endocrinology.
2017;63(5):346‑355. (In Russ.)
https://doi.org/10.14341/probl2017635346-355
Insulinoma is the most common functioning tumor of the pancreas. It consists of β-cells of the Langerhans islets. Insulinoma is malignant in 10% of cases and multifocal in 10% of cases. This review discusses the new capabilities for identification of the exact location of insulinoma, in particular given the latest data on expression of different receptors in the tumor tissue. We discuss the modern concept of molecular and genetic aspects of insulinoma development. In particular, we analyze studies on germinal and somatic mutations and epigenetic abnormalities. We describe new biochemical markers of insulinoma, which may be used for differential diagnosis, timely detection of insulinoma recurrence and progression, individual prognosis, and monitoring of treatment. Also, we discuss application of antitumor medications and optimal drug correction of hypoglycemia in insulinoma patients.
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Iukina M.Iu.
FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Nuralieva N.F.
Endocrinology Research Centre, Moscow, Russia
Troshina E.A.
Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Kuznetsov N.S.
Endocrinology Research Centrer
Platonova N.M.
Endocrinology Research Centre, Moscow, Russia
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