Objective. To use life-time determination of the topographic and anatomical characteristics of the prostate gland and to compare the obtained data with the already existing ones. Subjects and methods. Pelvic magnetic resonance imaging (MRI) scans were studied and interpreted in mature male patients (n=80) aged 21 to 59 years who were divided into two maturity (21—35 year) and (35—59 year) periods of 40 patients each. Diagnostic images were obtained on a MRI scanner (1.5 T Siemens Magnetom Symphony, Germany). The sampling criteria were the absence of urinary complaints and pelvic volumetric processes and other pathological changes. The linear dimensions of the prostate, its volume, skeletotopy, and syntopy were estimated. The prostate gland was beneath the plane of the aperture of the pelvis, located midway in the cavity of the latter. The mean prostate volume was 23.1±0.8 cm3 in the first maturity period and 26±0.9 cm3 in the second one, with an overwhelming predominance of patients (n=46 from the sample) having the mean values. Results. The first and second maturity period parameters of the prostate and its relationship to the bone structures of the pelvis and adjacent organs were comparatively analyzed. There was a a significant (average 2.9 cm3) increase in the prostate volume in the second maturity period as compared with that in the first one and an average 0.3—0.5 cm decrease in the distance to the pelvic bone structures in the sagittal and frontal planes. Conclusion. The differences in the syntopic parameters can be also due to the degree of rectal and urinary bladder filling, which requires functional studies with different filling of the above organs in the same patients (scheduled for subsequent work).