Brain metastases develop in 30—60% of patients with non-small cell lung cancer (NSCLC) and remain the main cause of a lower quality of life and higher mortality rates. Treatment for secondary lesions is of critical importance in improving survival and quality of life. Therefore, strategies are needed to improve outcomes in this patient population. Squamous cell lung cancer is a separate histological NSCLC subtype, difficult to treat due to specific clinical and pathological characteristics that include advanced age, marked comorbidity, and the central location of the primary lesion. These characteristics affect the outcomes of treatment for advanced squamous cell carcinoma therefore the median survival is approximately 30% shorter than that in patients with other NSCLC variants. The paper describes a clinical case of managing a patient with advanced squamous cell lung cancer, who underwent 3 neurosurgical interventions for various metastatic foci, three sessions of radiosurgical treatment, surgery for a primary lesion in the right lung, and 3 consecutive lines of drug treatment, during which progression can be controlled.