The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Pikin O.V.

Hertsen Moscow Oncology Research Institute

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Shcherbakova N.I.

Neurology Research Centre

Salimov Z.M.

Hertsen Moscow Oncology Research Institute

Kosumova Kh.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Martynova D.E.

Herzen Research Institute of Oncology

Subxiphoid rethymectomy in a female patient with thymoma associated with generalized myasthenia gravis

Authors:

Pikin O.V., Ryabov A.B., Shcherbakova N.I., Salimov Z.M., Kosumova Kh.S., Martynova D.E.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2022;11(1): 50‑54

DOI: 10.17116/onkolog20221101150

Read: 1377 times

Download PDF (RU)
Contact the author
Table of contents

SUBXIPHOID RETHYMECTOMY IN A FEMALE PATIENT WITH THYMOMA ASSOCIATED WITH GENERALIZED MYASTHENIA GRAVIS
SUBXIPHOID RETHYMECTOMY IN A FEMALE PATIENT WITH THYMOMA ASSOCIATED WITH GENERALIZED MYASTHENIA GRAVIS

To cite this article:

Pikin OV, Ryabov AB, Shcherbakova NI, Salimov ZM, Kosumova KhS, Martynova DE. Subxiphoid rethymectomy in a female patient with thymoma associated with generalized myasthenia gravis. P.A. Herzen Journal of Oncology. 2022;11(1):50‑54. (In Russ.)
https://doi.org/10.17116/onkolog20221101150

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Endo­scopic ultrasonography with transbronchial fine needle aspi­ration biopsy and thoracoscopic remo­val of ecto­pic middle mediastinal thymoma. P.A. Herzen Journal of Onco­logy. 2025;(2):41-46
Comparison of prognostic scales of myasthenic crisis after thymectomy in patients with myasthenia gravis. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):63-69
Clinical and epidemiological characteristics of myasthenia in the Altai region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):198-202
Clinical features and outcomes of video-assisted thoracoscopic thymectomies for thymic lymphomas. Endo­scopic Surgery. 2024;(6):18-23
Robo­tic and thoracoscopic surgeries for ante­rior mediastinal neoplasms. Piro­gov Russian Journal of Surgery. 2025;(2):6-12
New pathogenic treatments for myasthenia gravis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):31-38
Imme­diate resu­lts of thoracoscopic and open combined thymectomy: a two-center study. Piro­gov Russian Journal of Surgery. 2025;(5):58-64
Abstract:

Treatment for myasthenia gravis is standardized; however, there is a subgroup of patients who are refractory to therapy. In some patients with a high acetylcholine receptor antibody titer, thymectomy fails to produce the expected effect; the main reason for this is the residual thymic tissue that has not been removed during thymectomy. In some cases, it is necessary to resort to repeated surgical intervention (retymectomy). Subxiphoidal Kethymectomy is a safe and effective operation in patients with refractory myasthenia gravis that allows adequate removal of anterior mediastinal tissue in the presence of residual thymic tissue, as evidenced by chest CT, which is confirmed by the lower acetylcholine receptor antibody titer even a month after surgery, as shown by the described clinical case.

Keywords:

thymoma
rethymectomy
subxiphoid approach
myasthenia gravis

Authors:

Pikin O.V.

Hertsen Moscow Oncology Research Institute

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Shcherbakova N.I.

Neurology Research Centre

Salimov Z.M.

Hertsen Moscow Oncology Research Institute

Kosumova Kh.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Martynova D.E.

Herzen Research Institute of Oncology

Received:

02.06.2021

Accepted:

16.09.2021

Close metadata

References:

  1. Joome S, Jonathan M G, Richard J N. Clinical characteristics of refractory myasthenia gravis patients. Yale J Biol Med. 2013;86(2):255-260. 
  2. Pikin OV, Ryabov AB, Kolbanov KI, Stepanov SO. Opukholi sredosteniya: sbornik. Kaprin A.D., ed. M.: Molodaya gvardiya; 2019. (In Russ.).
  3. Cabrera-Maqueda JM, Alba-Isasi MT, Hernández R, Arroyo-Tristán A, Morales-Ortiz A. Thymectomy in thymomatous and non-thymomatous myasthenia gravis: analysis of a cohort of 46 patients. Rev Neurol. 2020;70(6):213-219.  https://doi.org/10.33588/rn.7006.2019411
  4. Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, et al. Randomized trial of thymectomy in myasthenia gravis. N Engl J Med. 2016;375(6):511-522.  https://doi.org/10.1056/NEJMoa1602489
  5. Aydin Y, Ulas AB, Mutlu V, Colak A, Eroglu A. Thymectomy in myasthenia gravis. Eurasian J Med. 2017;49(1):48-52.  https://doi.org/10.5152/eurasianjmed.2017.17009
  6. Narayanaswami P, Sanders DB, Wolfe G, Benatar M, Cea G, Evoli A, Gilhus NE, Illa I, Kuntz NL, Massey J, Melms A, Murai H, Nicolle M, Palace J, Richman D, Verschuuren J. International consensus guidance for management of myasthenia gravis: 2020 update. Neurology. 2021;96(3):114-122.  https://doi.org/10.1212/WNL.0000000000011124
  7. Henze A, Biberfeld P, Christensson B, Matell G, Pirskanen R. Failing transcervical thymectomy in myasthenia gravis. An evaluation of transsternal re-exploration. Scand J Thorac Cardiovasc Surg. 1984;18:235-238.  https://doi.org/10.3109/14017438409109897
  8. Li F, Li Z, Takahashi R, Ioannis A, Ismail M, Meisel A, Rueckert J, Robotic extended re-thymectomy for refractory myasthenia gravis: a case series. Semin Thorac Cardiovasc Surg. 2020;32(3):593-602.  https://doi.org/10.1053/j.semtcvs.2019.10.016
  9. Miller RG, Filler-Katz A, Kiprov D, Roan R. Repeat thymectomy in chronic refractory myasthenia gravis. Neurology. 1991;41(6):923-924.  https://doi.org/10.1212/wnl.41.6.923
  10. Mineo TC, Pompeo E, Ambrogi V, Bernardi G, Iani C, Sabato AF. Video-assisted completion thymectomy in refractory myasthenia gravis. J Thorac Cardiovasc Surg. 1998;115(1):252-254.  https://doi.org/10.1016/s0022-5223(98)70470-2
  11. Pompeo E, Nofroni I, Iavicoli N, Mineo TC. Thoracoscopic completion thymectomy in refractory nonthymomatous myasthenia. Ann Thorac Surg. 2000;70(3):918-923.  https://doi.org/10.1016/s0003-4975(00)01566-6
  12. Zieliński M, Kuzdzał J, Staniec B, Harazda M, Nabiałek T, Pankowski J, Szlubowski A, Narski M. Extended rethymectomy in the treatment of refractory myasthenia gravis: original video-assisted technique of resternotomy and results of the treatment in 21 patients. Interact Cardiovasc Thorac Surg. 2004;3(2):376-380.  https://doi.org/10.1016/j.icvts.2004.02.008
  13. Ivanovskaya TE, Zairat’yants OV, Leonova LV, Voloshchuk IN. Patologiya timusa u detei. SPb.: SOTIS; 1996. (In Russ.).
  14. Conwell LS, Batch JA. Aberrant cervical thymus mimicking a cervical mass. J Pediatr Child Health. 2004;40:579-580. 
  15. De Caluwe D, Ahmed M, Puri P. Cervical thymic cysts. Pediatr Surg Int. 2002;18(5-6):477-479.  https://doi.org/10.1007/s00383-002-0803-6
  16. JungJI, Kim HH, Park SH, Lee YS. Malignant ectopic thymoma in the neck: A case report. AJNR Am J Neuroradiol. 1999;20(9):1747-1749.
  17. Peel JK, Prisman E, Ng TL, McGuire AL. Ectopic thymoma managed by neck dissection & video-assisted thoracoscopic thymectomy. J Thorac Dis. 2017;9(12):E1050-1053. https://doi.org/10.21037/jtd.2017.10.141
  18. Zhihong Q, Liru C, Qin L, Hao W, Huangtao S, Xin Z, Yeji H, Lei P, Yangchun L, Quan X. Affiliations expand Perioperative outcomes and mid-term effects in performing video-assisted thoracoscopic extended thymectomy for myasthenia gravis: subxiphoid versus right thoracic approaches. J Thorac Dis. 2020;12(4):1529-1539. https://doi.org/10.21037/jtd.2020.03.43
  19. Mariusz R, Katarzyna Solarczyk-Bombik, Michal Wilkojc, Wojciech Czajkowski, Sylweriusz K, Edward F, Tomasz N, Malgorzata S, Juliusz P. Subxiphoid uniportal VATS thymectomy. Marcin. J Vis Surg. 2017;3:171.  https://doi.org/10.21037/jovs.2017.09.13
  20. Ambrogi V, Tacconi F, Sellitri F, Tamburrini A, Perroni G, Carlea F, La Rocca E, Vanni G, Schillaci O, Mineo TC. Subxiphoid completion thymectomy for refractory non-thymomatous myasthenia gravis. J Thorac Dis. 2020;12(5):2388-2394. https://doi.org/10.21037/jtd.2020.03.81
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.