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Podobed A.V.

N.N. Alexandrov National Cancer Center

Outcomes of combined operations for treatment of patients with locally advanced thymomas

Authors:

Podobed A.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(5): 7‑12

DOI: 10.17116/onkolog2025140517

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Table of contents

OUTCOMES OF COMBINED OPERATIONS FOR TREATMENT OF PATIENTS WITH LOCALLY ADVANCED THYMOMAS
OUTCOMES OF COMBINED OPERATIONS FOR TREATMENT OF PATIENTS WITH LOCALLY ADVANCED THYMOMAS

To cite this article:

Podobed AV. Outcomes of combined operations for treatment of patients with locally advanced thymomas. P.A. Herzen Journal of Oncology. 2025;14(5):7‑12. (In Russ.)
https://doi.org/10.17116/onkolog2025140517

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Imme­diate resu­lts of thoracoscopic and open combined thymectomy: a two-center study. Piro­gov Russian Journal of Surgery. 2025;(5):58-64
Abstract:

OBJECTIVE

Analysis of our own experience of combined thymectomy for locally advanced thymomas with a study of immediate and long-term results.

MATERIAL AND METHODS

The study included 28 patients with histologically confirmed locally advanced thymoma who underwent combined surgical interventions between September 2004 and December 2020.

RESULTS

Stage III according to Masaoka was 78.6% (22/28), IV — 21.4% (6/28). The distribution in accordance with the WHO classification was as follows: A — 10.7% (3/28), AB — 7.1% (2/28), B1 — 7.1% (2/28), B2 — 17.8 % (5/28), B3 — 10.7% (3/28), C — 46.4% (13/28). The prevalence of the primary tumor was: T2 — 28.6% (8/28), T3 — 60.7% (17/28), T4 — 10.7% (3/28). The most common sites of tumor invasion were the pericardium, lung, brachiocephalic vein, and superior vena cava. The median duration of surgery was 220 minutes, intraoperative blood loss was 300 ml, the duration of pleural drainage was 3 days, and hospitalization was 14 days. 5-year disease-specific survival for Masaoka stage III was 89.4% and relapse free survival was 59.8%, 10-year — 67.1% and 41.0%, respectively. Median sternotomy was used for 8 (28.6%) patients, partial cervicosternotomy — 2 (7.1%), and thoracotomy — 10 (35.7%). VATS thymectomy with pericardial resection was performed in 6 (21.4%) patients, lung — 3 (10.7%), phrenic nerve — 1 (3.6%), marginal resection of the left brachiocephalic vein — 1 (3.6%).

CONCLUSIONS

Combined thymectomy is an effective treatment for Masaoka stage III thymoma, yielding satisfactory long-term survival. In case of thymoma invasion into the lung, pericardium or brachiocephalic vein, combined VATS thymectomy with resection of involved structures is feasible in carefully selected patients.

Keywords:

combined thymectomy
thymoma
thymic carcinoma
videothoracoscopic thymectomy

Authors:

Podobed A.V.

N.N. Alexandrov National Cancer Center

Received:

27.02.2024

Accepted:

05.04.2024

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