Results of perioperative nutritional support in patients with gastric cancer

Sergienko A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Khoronenko V.E.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Gameeva E.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Results of perioperative nutritional support in patients with gastric cancer

Authors:

Sergienko A.D., Khomyakov V.M., Ryabov A.B., Khoronenko V.E., Gameeva E.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2021;10(6): 41‑48

DOI: 10.17116/onkolog20211006141

Downloaded: 17

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Sergienko AD, Khomyakov VM, Ryabov AB, Khoronenko VE, Gameeva EV. Results of perioperative nutritional support in patients with gastric cancer. P.A. Herzen Journal of Oncology. 2021;10(6):41‑48. (In Russ.)
https://doi.org/10.17116/onkolog20211006141

Close metadata

OBJECTIVE

To improve the immediate results of surgical treatment in patients with gastric cancer, by timely prescribing nutritional therapy at all stages of examination and treatment.

SUBJECTS AND METHODS

The examination included 62 patients who had undergone surgery for gastric cancer. All the patients were randomized to 2 comparable groups: a control group (n=25) that kept to a preoperative high-protein diet; a study group (n=37) that additionally received 10-day preoperative enteral sipping formulas containing 250 ml/day (600 kcal and 36 g of protein per day). Postoperative management was unified and performed according to the developed protocol.

RESULTS

The additional nutritional support group showed the noticeable tendency to improve its nutritional status, which persisted even in the postoperative period. During the preoperative preparation, ferritin levels changed considerably in both the study and control groups. There was a significant difference in the time to onset of peristalsis and spontaneous bowel movement: the mean time to onset of peristalsis in the study and control groups was 1 and 2 days, respectively; the mean time to onset of spontaneous bowel movement in the study and control groups was 4 and 6 days, respectively. The patients who received sipping formulas exhibited a significant change in the indicator «general health», as well as decreased pain sensation intensity, improved food assimilation processes, and better general and physical health conditions, increased overall tone and energy, an energy surge, and a feeling of invigoration.

CONCLUSION

The absence of preoperative additional nutritional support leads to a significant deterioration of the nutritional status and a decrease in ferritin levels, which persist throughout the perioperative period. When undergoing the same postoperative management tactics, the additional preoperative substrate support group displays a faster restoration in total protein levels, earlier onset of peristalsis and spontaneous bowel movement, and improved patient quality of life.

Keywords:

malnutrition

nutritional support

gastric cancer

enteral nutrition

Authors:

Sergienko A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Khoronenko V.E.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Gameeva E.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Received:

11.10.2021

Accepted:

20.10.2021

List of references:

Tan BH, Brammer K, Randhawa N, Welch NT, Parsons SL, James EJ, et al. Sarcopenia is associated with toxicity in patients undergoing neo-adjuvant chemotherapy for oesophago-gastric cancer. European Journal of Surgical Oncology. 2015;41(3):333-338. https://doi.org/10.1016/j.ejso.2014.11.040
Anandavadivelan P, Brismar TB, Nilsson M, Johar AM, Martin L. Sarcopenic obesity: a probable risk factor for dose limiting toxicity during neoadjuvant chemotherapy in oesophageal cancer patients. Clinical Nutrition. 2016;35(3):724-730. https://doi.org/10.1016/j.clnu.2015.05.011
Barret M, Malka D, Aparicio T, Dalban C, Locher C, Sabate J-M, et al. Nutritional status affects treatment tolerability and survival in metastatic colorectal cancer patients: results of an AGEO prospective multicenter study. Oncology. 2011;81(5-6):395-402. https://doi.org/10.1159/000335478
Aslani A, Smith RC, Allen BJ, Pavlakis N, Levi JA. The predictive value of body protein for chemotherapy-induced toxicity. Cancer. 2000;88(4):796-803. https://doi.org/10.1002/(sici)1097-0142(20000215)88:4<796::aid-cncr10>3.0.co;2-p "> 3.0.co;2-p" target="_blank">https://doi.org/10.1002/(sici)1097-0142(20000215)88:4<796::aid-cncr10>3.0.co;2-p
Cessot A, Hebuterne X, Coriat R, Durand JP, Mir O, Mateus C, et al. Defining the clinical condition of cancer patients: it is time to switch from performance status to nutritional status. Supportive Care in Cancer. 2011;19(7):869-870. https://doi.org/10.1007/s00520-011-1122-z
Gupta D, Vashi PG, Lammersfeld CA, Braun DP. Role of nutritional status in predicting the length of stay in cancer: a systematic review of the epidemiological literature. Annals of Nutrition and Metabolism. 2011;59(2-4):96-106. https://doi.org/10.1159/000332914
Laky B, Janda M, Kondalsamy-Chennakesavan S, Cleghorn G, Obermair A. Pretreatment malnutrition and quality of life — association with prolonged length of hospital stay among patients with gynecological cancer: a cohort study. BMC Cancer. 2010;10(1):232-237. https://doi.org/10.1186/1471-2407-10-232
Segura A, Pardo J, Jara C, Zugazabeitia L, Carulla J, Peñas R, et al. An epidemiological evaluation of the prevalence of malnutrition in Spanish patients with locally advanced or metastatic cancer. Clinical Nutrition. 2005;24(5):801-814. https://doi.org/10.1016/j.clnu.2005.05.001
Shenkin A, Cederblad G, Elia M, Isaksson B. Laboratory assessment of protein energy status. Journal of the International federation of clinical chemistry. 1996;8(2):58-61. https://doi.org/10.1016/0009-8981(96)06289-4
Lee SM, Choi MS, Kim YS, Lee JB, Shin CS. Nosocomial infection of malnourished patients in an intensive care unit. Yonsei Medical Journal. 2003;44(2):203-209. https://doi.org/10.3349/ymj.2003.44.2.203
Marshall KM, Loeliger J, Nolte L, Kelaart A, Kiss NK. Prevalence of malnutrition and impact on clinical outcomes in cancer services: A comparison of two time points. Clinical Nutrition. 2019;38(2):644-651. https://doi.org/10.1016/j.clnu.2018.04.007
Elwyn DH, Bryan-Brown CW, Shoemaker WC. Nutritional aspects of body water dislocations in postoperative and depleted patients. Annals of Surgery. 1975;182(1):76-85. https://doi.org/10.1097/00000658-197507000-00015
Kinney JM, Weissman C. Forms of malnutrition in stressed and unstressed patients. Clinics in Chest Medicine. 1986;7:19-28. https://doi.org/10.1016/s0272-5231(21)00318-x
Mainous MR, Deitch EA. Nutrition and infection. Surgical Clinics of North America. 1994;74(3):659-676. https://doi.org/10.1016/s0039-6109(16)46335-8
Hopkinson JB. Food connections: a qualitative exploratory study of weight-and eating-related distress in families affected by advanced cancer. European Journal of Oncology Nursing. 2016;20:87-96. https://doi.org/10.1016/j.ejon.2015.06.002.
Langius JA, Zandbergen MC, Eerenstein SE, van Tulder MW, Leemans CR, Kramer MHH, et al. Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo) radiotherapy: a systematic review. Clinical Nutrition. 2013;32(5):671-678. https://doi.org/10.1016/j.clnu.2013.06.012
Carey S, Storey D, Biankin AV, Martin D, Young J, Allman-Farinelli M. Long term nutritional status and quality of life following major upper gastrointestinal surgery — a cross-sectional study. Clinical Nutrition. 2011;30(6):774-779. https://doi.org/10.1016/j.clnu.2011.03.003
Nakamura M, Nakamori M, Ojima T, Iwahashi M, Horiuchi T, Kobayashi Y, et al. Randomized clinical trial comparing long-term quality of life for Billroth I versus Roux-en-Y reconstruction after distal gastrectomy for gastric cancer. British Journal of Surgery. 2016;103(4):337-347. https://doi.org/10.1002/bjs.10060.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organisation for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute. 1993;85:365-376. https://doi.org/10.1093/jnci/85.5.365

Close metadata