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Berezovskaya T.P.

A.F. Tsyba Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Dayneko Ya.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Nevol'skikh A.A.

Meditsinskiĭ radiologicheskiĭ nauchnyĭ tsentr RAMN, Obninsk

Ivanov S.A.

A.F. Tsyba Medical Radiological Research Centre — Branch of the National Medical Research Center of Radiology of the Ministry of Healthcare of the Russia, Obninsk, Russia

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Evaluation of the efficiency of neoadjuvant chemoradiation therapy for colorectal cancer on the basis of texture analysis of T2-weighted MR images

Authors:

Berezovskaya T.P., Dayneko Ya.A., Nevol'skikh A.A., Ivanov S.A., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2019;8(4): 243‑249

DOI: 10.17116/onkolog20198041243

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Table of contents

EVALUATION OF THE EFFICIENCY OF NEOADJUVANT CHEMORADIATION THERAPY FOR COLORECTAL CANCER ON THE BASIS OF TEXTURE ANALYSIS OF T2-WEIGHTED MR IMAGES
EVALUATION OF THE EFFICIENCY OF NEOADJUVANT CHEMORADIATION THERAPY FOR COLORECTAL CANCER ON THE BASIS OF TEXTURE ANALYSIS OF T2-WEIGHTED MR IMAGES

To cite this article:

Berezovskaya TP, Dayneko YaA, Nevol'skikh AA, Ivanov SA, Kaprin AD. Evaluation of the efficiency of neoadjuvant chemoradiation therapy for colorectal cancer on the basis of texture analysis of T2-weighted MR images. P.A. Herzen Journal of Oncology. 2019;8(4):243‑249. (In Russ.)
https://doi.org/10.17116/onkolog20198041243

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

Neoadjuvant chemoradiation therapy (nCRT) for rectal cancer (RC) can achieve a complete disappearance of the tumor in some patients. Therapeutic tactics for these cases can be individualized during preoperative clinical identification. At present, data have been obtained on the possibility of improving the accuracy of assessing a tumor response using a texture analysis of T2-weighted MR images (T2WIs). Objective — to study whether the texture analysis of T2WIs can be used to evaluate the efficiency of nCRT in the combined treatment of patients with RC. Subject and methods. Before and after long-term nCRT, the texture analysis of high-resolution T2WIs was retrospectively carried out in 42 patients with RC who received combined treatment. Pathological examination of surgical specimens could identify groups of respondents (Group 1) and non-respondents (Group 2) to nCRT. Tumor texture (TT) parameters were determined with the MaZda (version 4.6) computer program using the Gray-Level Co-Occurrence Matrix (GLCM) technique. Data on 11 TT parameters were statistically processed to identify differences in Groups 1 and 2. Results. Group 1 included 20 patients; Group 2 consisted of 22 patients. During nCRT, Group 1 showed significant changes in 8 of the 11 TT parameters: second angular momentum (AngScMom), p=0.0017; contrast, p=0.0424; correlation (Correlat), p=0.0045; homogeneity (InvDfMom), p=0,60240; total dispersion (SumVarnc), p=0.0011; entropy, p=0.0004; differential dispersion (DifVarnc), 0.0284 and differential entropy (DifEntrp), p=0.0055, whereas Group 2 displayed changes in only two parameters: AngScMom (p=0.0040) and entropy (p=0.0007). In Groups 1 and 2, there were significant differences in the baseline TT parameters in AngScMom (p=0.2124); dispersion (SumofSqs), p=0.0028; SumVarnc (p=0.0150); entropy (p=0.0377) and total entropy (SumEntrp), p=0.0031, and in the posttherapy parameters in AngScMom (p=0.0000); InvDfMom (p=0.0310); entropy (p=0.0000); SumEntrp (p=0.0011) and DifEntrp (p=0.0480). Conclusions. The found significant differences in the TT parameters in Groups 1 and 2 suggest that it is feasible to continue investigations of the texture analysis used in patients receiving combined treatment for RC and to identify criteria for predicting and evaluating the efficiency of nCRT.

Keywords:

rectal cancer
magnetic resonance imaging
radiomics
texture analysis
evaluation of treatment efficiency
restaging

Authors:

Berezovskaya T.P.

A.F. Tsyba Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Dayneko Ya.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk, Russia

Nevol'skikh A.A.

Meditsinskiĭ radiologicheskiĭ nauchnyĭ tsentr RAMN, Obninsk

Ivanov S.A.

A.F. Tsyba Medical Radiological Research Centre — Branch of the National Medical Research Center of Radiology of the Ministry of Healthcare of the Russia, Obninsk, Russia

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

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References:

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