Dynamics of permeability of the blood-brain barrier after FUS thalamotomy according to contrast-enhanced MRI

Dolgushin MB, Prischepina KA, Martynov MYu, et al. . Dynamics of permeability of the blood-brain barrier after FUS thalamotomy according to contrast-enhanced MRI. Burdenko's Journal of Neurosurgery. 2025;89(4):51‑60. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258904151

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To study the dynamics of permeability of the blood-brain barrier (BBB) after focused ultrasound (FUS) thalamotomy in patients with tremor of different origin through visualization phenomena, assessment of the tendency of contrast accumulation level change at MRI in coagulation necrosis focus over different time intervals.

MATERIAL AND METHODS

The study included 10 patients (8 — with Parkinson’s disease, 2 — with essential tremor). MRI of the brain was performed before the procedure, MRI of the brain with contrast enhancement («Gadobutrol») was carried out after 2 and 24 hours, 1, 3, 6 and 12 months from FUS thalamotomy. The volume and nature of contrast accumulation in the impact area were evaluated.

RESULTS

Observations show that the performance of FUS thalamotomy leads to a temporary impairment of the BBB permeability. This is confirmed by the data of dynamic accumulation of contrast substance in MRI in the area of coagulation necrosis.

CONCLUSION

The analysis of the dynamic changes of volume and patterns of accumulation of contrast substance in MRI in the area of coagulation necrosis after FUS thalamotomy was performed during the study. The obtained data demonstrate almost complete absence of contrast enhancement 24 hours after intervention, that may indicate a partial restoration of the structural-functional integrity of BBB after its transient disruption in the early postoperative period.

Keywords:

blood-brain barrier

focused ultrasound

FUS

tremor

Parkinson’s disease

essential tremor

magnetic resonance imaging

thalamotomy

Authors:

Dolgushin M.B.

Federal Center of Brain and Neurotechnologies of the Federal Medical Biological Agency

ORCID: 0000-0003-3930-5998

Prischepina K.A.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0009-4522-161X

Martynov M.Yu.

Pirogov Russian National Research Medical University

SPIN RSCI: 8010-8340
Scopus AuthorID: 7004761286
ResearcherID: K-8390-2018
ORCID: 0000-0003-2797-7877

Gumin I.S.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0003-2360-3261

Katunina E.A.

Pirogov Russian National Research Medical University

ORCID: 0000-0001-5805-486X

Senko I.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0002-5743-8279

Tairova R.T.

Pirogov Russian National Research Medical University

ORCID: 0000-0002-4174-7114

Dvoryanchikov A.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0009-0678-7821

Received:

01.10.2024

Accepted:

05.06.2025

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