Radiotherapy in the treatment of melanoma metastases to the skin, soft tissues, and visceral organs

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The author presents the results of her investigations into combined radiation, drug, and photodynamic treatment for melanoma metastases to the skin, soft tissues, and visceral organs, which developed late after management of the primary focus. One hundred and thirteen patients had melanoma metastases to the skin and soft tissues and 26 had those to the visceral organs, including 12 patients with solitary metastases to the lungs. The developed treatment algorithm for metastatic melanoma could improve immediate and late treatment outcomes. There was a significant improvement in quality of life and an increase in overall and metastasis-free survival.

Keywords:

metastatic melanoma

radiotherapy

drug therapy

photodynamic therapy

Authors:

Zakurdiaeva I.G.

FGBU "Meditsinskiĭ radiologicheskiĭ nauchnyĭ tsentr"

List of references:

Eggermont A.M. Randomized trials in melanoma: An update. Surg. Oncol. Clin. N. Am. 2006; 15: 439-51.
Bedikian A.Y., Millward M., Pehamberger H. et al. Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The Oblimersen Melanoma Study Group. J. Clin. Oncol. 2006; 24: 4738-45.
Chapman P.B., Einhorn L.H., Meyers M.L. et al. Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J. Clin. Oncol. 1999; 17: 2745-51.
Cornett W.R. et al. American College of Surgeons Oncology Group Trial Z0020. Randomized multicenter trial of hyperthermic isolated limb perfusion with Melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. J. Clin. Oncol. 2006; 24: 4196-201.
Middleton M.R., Grob J.J., Aaronson N. et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J. Clin. Oncol. 2000; 18: 158-66.
Thompson J.F., Scolyer R.A., Kefford R.F. Cutaneous melanoma. Lancet. 2005; 365: 687-701.
Tigel D.S., Carucci J.A. Malignant melanoma: Prevention, early detection, and treatment in the 21st century CA. Cancer J. Clin. 2000; 50: 215-36.
Ives N.J., Stowe R.L., Lorigan P., Wheatley K. Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients. J. Clin. Oncol. 2007; 25: 5426-34.
Bert D.M. An autologous, haptenmodified vaccine for human cancer. Expert Rev. Vaccines. 2004; 3: 521-7.
Hsueh E.C., Morton D.L. Antigen-based immunotherapy of melanoma: Canvaxin therapeutic polyvalent cancer vaccine. Semin. Cancer Biol. 2003; 13 (16): 401-7.
Chapman P.B., Wu D., Ragupathi G. et al. Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside. Clin. Cancer Res. 2004; 10: 4717-23.
Jager E., Karbach J., Gnjatic S. et al. Recombinant vaccine/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patients. Proc. Natl. Acad. Sci. USA. 2006; 103: 14453-8.
van Baren N., Bonnet M.C., Dreno B. et al. Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells. J. Clin. Oncol. 2005; 23: 9008-21.
Di Pucchio T., Pilla L., Capone I. et al. Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp 100 peptides plus IFN-alfa results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. Cancer Res. 2006; 66: 4943-51.
Markovic S.N., Suman V.J., Ingle J.N. et al. Peptide vaccination of patients with metastatic melanoma: Improved clinical outcome in patients demonstrating effective immunization. Am. J. Clin. Oncol. 2006; 29: 352-60.
Rosenberg S.A., Yang J.C., Schwartzentruber D.J. et al. Recombinant fowlpox viruses encoding the anchor-modified gp 100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma. Clin. Cancer Res. 2003; 9: 2973-80.
Belli F., Testori A., Revoltini L. et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findigs. J. Clin. Oncol. 2002; 20: 4169-80.
Hsueh E.C., Essner R., Foshag L.J. et al. Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine. J. Clin. Oncol. 2002; 20 (23): 4549-54.
Zakurdyaeva I.G., Kudryavtseva G.T., Kaplan M.A., Kapinus V.N., Borgul' O.V. Sistemnaya fotodinamicheskaya terapiya v kombinirovannom lechenii disseminirovannoi melanomy kozhi. Rossiiskii bioterapevticheskii zhurnal. 2008; 7 (1): 16-7.
Kaplan M.A., Kudryavtseva G.T., Zakurdyaeva I.G., Borgul' O.V., Kozlova E.M., Ponomarev G.V. Predvaritel'nye rezul'taty sistemnoi vnutrivennoi fotodinamicheskoi terapii zlokachestvennykh opukholei III-IV stadii razvitiya protsessa. Fizicheskaya meditsina. 2005; 15 (1): 39-40.
Borgul' O.V. Fotodinamicheskaya terapiya kozhnykh metastazov pri disseminirovannoi melanome kozhi: Dis. ... kand. med. nauk. Obninsk; 2007. 123 s.
Balch C.M., Buzaid A.C., Soong S.J. et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol. 2001; 19: 3635-48.
Demidov L.V. Khirurgicheskaya "pogonya" za metastazami melanomy. V kn.: Materialy V Rossiiskoi onkologicheskoi konferentsii. M.; 2001: 112-3.
Leo F., Cagini L., Rocmans P. et al. Lung metastases from melanoma: when is surgical treatment warranted? Br. J. Cancer. 2000; 83 (5): 569-472.
Middleton M.R., Grob J.J., Aaronson N. et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J. Clin. Oncol. 2000; 18: 158-66.
Macke R.M. et al. Osobennosti zabolevaniya i obshchie printsipy vedeniya bol'nykh melanomoi kozhi. Demidov L.V., red. M.; 2004. 24 s.
Minimal'nye klinicheskie rekomendatsii Evropeiskogo obshchestva meditsinskoi onkologii (ESMO). M.: Meditsina; 2009. 287 s.
Chissov V.I., Trakhtenberg A.Kh., Pikin O.V., Parshin V.D. Metastaticheskie opukholi legkikh. M.: GEOTAR-Media; 2009: 114-5.
Krylov V.V. Radionuklidnaya terapiya samariem oksabiforom, 153Sm pri metastaticheskikh porazheniyakh kostei: Dis. ... d-ra med. nauk. Obninsk; 2007. 285 s.
Komarov I.G., Komov D.V. Metastazy zlokachestvennykh opukholei bez vyyavlennogo pervichnogo ochaga. M.: Triada-Kh; 2002: 88-9.
Medina-Franco H., Urist M.M. Occult breast carcinoma presenting with axillary lymph node metastases. Rev. Invest. Clin. 2002; 54 (3): 204-8.
Zuur C., van Velthuysen M., Schornagel G.H., Hilgers F.J., Balm A.J. Diagnosis and treatment of isolated neck metastases of adenocarcinomas. Eur. J. Surg. Oncol. 2002; 28 (2): 147-52.

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