Cutaneous melanoma in children

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The paper deals with the state-of-the-art of diagnosis and treatment in children with cutaneous melanoma. It presents the long-term results of treatment in children with cutaneous melanoma in the Republic of Belarus in 1991 to 2011. A total of 23 children were treated. All the children underwent tumor excision; three children additionally received chemotherapy and/or biotherapy and radiotherapy. One patient was given courses of adjuvant chemotherapy with whole body hyperthermia. Ten-year event-free survival rate was 90%. The author's experience suggests that the results of treatment are much better in children than in adults; wide excision of cutaneous melanoma is the method of choice in the treatment of its non-metastatic form. Chemotherapy and/or biotherapy, as well as radiotherapy may be used to treat metastatic forms of the disease.

Keywords:

cutaneous melanoma in children; surgical treatment

chemotherapy

biotherapy

hyperthermia

Authors:

Ismail-zade R.S.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr detskoĭ onkologii, gematologii i immunologii, Minsk, Belarus'

List of references:

Ries LAG., Smith M.A., Gurney J.G. et al., eds. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649. Bethesda; 1999.
Desandes E., Clavel J., Berger C. et al. Cancer incidence among children in Ranee, 1990-1999. Pediatr. Blood Cancer. 2004; 43: 749-57.
Huynh P.M., Grant-Kels J.M., Grin C.M. Childhood melanoma: update and treatment. Int. J. Dermatol. 2005; 44 (9): 715-23.
Chernova N.V., Durnov L.A., Lebedev V.I., Sharoev T.A., Polyakov V.G., Yasonov A.V., Bondarev I.V. Melanoma kozhi u detei. Pediatriya. Zhurnal im. G.N. Speranskogo. 1999; 3; 65-9.
Kazubskaya T.P., Musatov V.K., Mikhailovskii A.V. i dr. Rossiiskii onkologicheskii zhurnal. 2003; 3: 26-33.
Kefford R.F., Newton Bishop J.A., Bergman W. et al. Counseling and DNA testing for individuals perceived to be genetically predisposed to melanoma: A consensus statement of the Melanoma Genetics Consortium. J. Clin. Oncol. 1999; 17 (10): 3245-
Monzon J., Liu L., Brill H. et al. CDKN2A mutations in multiple primary melanomas. N. Engl. J. Med. 1998; 338 (13): 879-87.
Richardson S.K., Tannous Z.S., Mihm M.C. Jr. Congenital and infantile melanoma: review of the literature and report of an uncommon variant, pigment-synthesizing melanoma. J. Am. Acad. Dermatol. 2002; 47 (1): 77-90.
Freedman W.L., McMahon F.J. Placental metastasis: review of the literature and report of a case of metastatic melanoma. Obstet. Gynecol. 1960; 16: 550-60.
Wang R., Rabinovitz H., Kopf A.W. et al. Current technologies for the in vivo diagnosis of cutaneous melanomas. Clin. Dermatol. 2004; 22 (3): 217-22.
Balch S.M., Buzaid A.C., Soong S.J. et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol. 2001; 19 (16): 3635-46.
Clark W.H. Jr., From L., Bernardino E.A. et al. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969; 29 (3): 705-27.
Fradkin S.Z., Zalutskii I.V. Melanoma kozhi. Minsk: Belarus'; 2000. 221 s.
Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann. Surg. 1970; 172 (5): 902-8.
Balch C.M., Houghton A.N., Sober A.J et al. Cutaneous melanoma. St Louis: Quality Medical Press; 2003.
Thompson J.F., Scolyer R.A., Kefford R.F. Cutaneous melanoma. Lancet. 2005; 365 (9460): 687-701.
NCCN Melanoma. Melanoma: clinical practice guidelines in oncology. J. Natl. Comp. Cancer Netw. 2004; 2 (1): 46-60.
Cascinelli N., Morabito A., Santinami M. et al. Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomized trial. WHO Melanoma Programmer. Lancet. 1998; 351 (9105): 793-6.
Morton D.L., Hoon D.S., Cochran A.J. et al. Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases. Ann. Surg. 2003; 238 (4): 538-49.
Kirkwood J.M., Strawderman M.H., Ernstoff M.S. et al. Interferon-α2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group trial. J. Clin. Oncol. 1996; 14; 7-17.
Boddie A.W. Jr., Cangir A. Adjuvant and neoadjuvant chemotherapy with decarbazine in high-risk childhood melanoma. Cancer. 1987; 60: 1720-3.
Ismail-zade R.S. Obshchaya upravlyaemaya gipertermiya v lechenii daleko zashedshikh zlokachestvennykh opukholei u detei. Minsk: Ekonompresc; 2007. 167 s.
Oldham R.K. Principles of cancer biotherapy. Dordrecht; Boston; London: Kluwer Academic Publishers; 2003. 230 p.

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