The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Boldyrev N.D.

State Scientific Center of Virology and Biotechnology “Vector”

Panova A.S.

State Scientific Center of Virology and Biotechnology “Vector”

Kolosova N.P.

State Scientific Center of Virology and Biotechnology “Vector”

Danilenko A.V.

State Scientific Center of Virology and Biotechnology “Vector”

Onkhonova G.S.

State Scientific Center of Virology and Biotechnology “Vector”

Svyatchenko S.V.

State Scientific Center of Virology and Biotechnology “Vector”

Marchenko V.Yu.

State Scientific Center of Virology and Biotechnology “Vector”

Ryzhikov A.B.

State Scientific Center of Virology and Biotechnology “Vector”

Comparative analysis of influenza viruses isolated from first and severe cases in Russia in epidemiological seasons before and during COVID-19 pandemic (2019—2023)

Authors:

Boldyrev N.D., Panova A.S., Kolosova N.P., Danilenko A.V., Onkhonova G.S., Svyatchenko S.V., Marchenko V.Yu., Ryzhikov A.B.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2023;41(4): 21‑30

DOI: 10.17116/molgen20234104121

Read: 1442 times

Download PDF (RU)
Contact the author
Table of contents

COMPARATIVE ANALYSIS OF INFLUENZA VIRUSES ISOLATED FROM FIRST AND SEVERE CASES IN RUSSIA IN EPIDEMIOLOGICAL SEASONS BEFORE AND DURING COVID-19 PANDEMIC (2019—2023)
COMPARATIVE ANALYSIS OF INFLUENZA VIRUSES ISOLATED FROM FIRST AND SEVERE CASES IN RUSSIA IN EPIDEMIOLOGICAL SEASONS BEFORE AND DURING COVID-19 PANDEMIC (2019—2023)

To cite this article:

Boldyrev ND, Panova AS, Kolosova NP, et al. . Comparative analysis of influenza viruses isolated from first and severe cases in Russia in epidemiological seasons before and during COVID-19 pandemic (2019—2023). Molecular Genetics, Microbiology and Virology. 2023;41(4):21‑30. (In Russ.)
https://doi.org/10.17116/molgen20234104121

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Diffuse changes in the brain in the acute phase of COVID-19 and after infe­ction. Russian Journal of Archive of Pathology. 2025;(1):5-15
Liver pathology in COVID-19. Russian Journal of Archive of Pathology. 2025;(1):53-59
The algo­rithm for clinical and audiological obse­rvation of children born preterm. Russian Bulletin of Otorhinolaryngology. 2025;(1):20-28
A clinical case of the aortic rupture after SARS-CoV-2 in the patient with Stickler syndrom. Russian Journal of Preventive Medi­cine. 2025;(3):103-106
Cough diagnosis: from origins to modern times (review of lite­rature). Journal of Respiratory Medi­cine. 2025;(1):38-42
A rational approach to the prevention and treatment of ARVI and influenza, as a medico-economic and socially significant problem of the XXI century. Journal of Respiratory Medi­cine. 2025;(1):43-48
Post-COVID syndrome: orga­nizing COVID-19-associated pneumonia. Clinical case. Journal of Respiratory Medi­cine. 2025;(1):65-72
Coro­navirus infe­ction as a risk factor in occlusive-stenotic lesions of the brachiocephalic arte­ries. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):44-52
Hemo­dynamic para­meters of venous return and their role in asse­ssment of fluid responsiveness in cardiac surgery. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):6-12
SpO2/RR index in choosing the method for correction of acute respiratory failure in COVID-19 patients. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):50-58
Abstract:

The influenza virus continues to be considered one of the most dangerous respiratory pathogens, and the study of the influenza virus is important for epidemiological control, especially in the case of co-circulation with SARS-CoV-2.

OBJECTIVE

Comparative analysis of influenza viruses isolated from first and severe cases in epidemic seasons before and during the COVID-19 pandemic in Russia.

MATERIAL AND METHODS

The article is based on the results of monitoring the circulation of seasonal influenza viruses obtained in 2019—2023. Samples from the first and severe cases of influenza were studied by PCR diagnostics and full-genome sequencing methods. Antigenic characterization of isolated viruses was performed, and their sensitivity to antiviral drugs was investigated.

RESULTS

The 2019—2020 influenza season in Russia was the last epidemic season before the COVID-19 pandemic with predominant co-circulation of influenza B and influenza A/H1N1pdm09 viruses. After the start of the pandemic, in the 2020—2021 season the influenza virus was virtually absent from circulation in Russia. Virus circulation resumed in the 2021—2022 season with A/H3N2 dominance (clade 3C.2a1b.2a2) and continued in the 2022—2023 season with A/H1N1pdm09 dominance (clade 6B.1A.5a.2a) and the spread of influenza B/Victoria viruses (clade V1A.3a.2), antigenically distinct from the viruses circulating prior to the COVID-19 pandemic. Genetic analysis of D222G/N mutations in the hemagglutinin of A/H1N1pdm09 viruses associated with increased disease severity revealed approximately equivalent selection of D222G and D222N mutations in the 2019—2020 season and increased occurrence of the D222N variant in the 2022—2023 season.

CONCLUSION

The co-circulation with SARS-CoV-2, the return of influenza circulation to epidemic levels, and the emergence of new antigenic variants and pathogenicity factors emphasize the need to monitor and study influenza viruses for epidemiological analysis and prognosis, as well as for the development and application of effective measures to protect the population.

Keywords:

influenza
monitoring
COVID-19
A/H1N1pdm09
A/H3N2
B/Victoria
D222N/G polymorphism

Authors:

Boldyrev N.D.

State Scientific Center of Virology and Biotechnology “Vector”

Panova A.S.

State Scientific Center of Virology and Biotechnology “Vector”

Kolosova N.P.

State Scientific Center of Virology and Biotechnology “Vector”

Danilenko A.V.

State Scientific Center of Virology and Biotechnology “Vector”

Onkhonova G.S.

State Scientific Center of Virology and Biotechnology “Vector”

Svyatchenko S.V.

State Scientific Center of Virology and Biotechnology “Vector”

Marchenko V.Yu.

State Scientific Center of Virology and Biotechnology “Vector”

Ryzhikov A.B.

State Scientific Center of Virology and Biotechnology “Vector”

Received:

28.10.2023

Accepted:

13.11.2023

Close metadata

References:

  1. Petersen E, Koopmans M, Go U, Hamer DH, Petrosillo N, Castelli F, Storgaard M, Al Khalili S, Simonsen L. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics. Lancet Infect Dis. 2020;20(9): e238-e244. https://doi.org/10.1016/S1473-3099(20)30484-9
  2. WHO. Recommended Composition of Influenza Virus Vaccines for Use in the 2022 Southern Hemisphere Influenza Season. https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2022-southern-hemisphere-influenza-season
  3. WHO. Recommended Composition of Influenza Virus Vaccines for Use in the 2022—2023 Northern hemisphere Influenza Season. https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-foruse-in-the-2022-2023-northern-hemisphere-influenza-season
  4. Stowe J, Tessier E, Zhao H, Guy R, Muller-Pebody B, Zambon M, et al. Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: A test-negative design. Int J Epidemiol. 2021;50(4):1124-1133. https://doi.org/10.1093/ije/dyab081
  5. https://rospotrebnadzor.ru/region/structure/str_fguz.php 
  6. WHO. Global Influenza Programme. Manual for the laboratory diagnosis and virological surveillance of influenza. WHO; 2011. https://www.who.int/publications/i/item/manual-for-the-laboratory-diagnosis-and-virological-surveillance-of-influenza
  7. Leang S-K, Hurt AC. Fluorescence-Based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals. J Vis Exp. 2017;122:e55570. https://doi.org/10.3791/55570
  8. Kolosova NP, Ilyicheva TN, Danilenko AV, Svyatchenko SV, Goncharova NI, Bulanovich JA, Torzhkova PY, Durymanov AG, Gudymo AS, Shvalov AN, Susloparov IM, Tregubchak TV, Gavrilova EV, Maksyutov RA, Ryzhikov AB. Severe cases of seasonal influenza and detection of seasonal A(H1N2) in Russia in 2018—2019. Arch Virol. 2020;165(9): 2045-2051. https://doi.org/10.1007/s00705-020-04699-z
  9. Global Influenza Programme. FluNet. https://www.who.int/tools/flunet
  10. WHO. Recommended composition of influenza virus vaccines for use in the 2021 southern hemisphere influenza season, September, 2020. https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2021_-southern-hemisphere-influenza-season
  11. WHO. Recommended composition of influenza virus vaccines for use in the 2021—2022 northern hemisphere influenza season. https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2021-2022-northern-hemisphere-influenza-season
  12. Kolosova NP, Ilyicheva TN, Danilenko AV, Bulanovich JA, Svyatchenko SV, Durymanov AG, Goncharova NI, Gudymo AS, Shvalov AN, Susloparov IM, Marchenko VY, Tregubchak TV, Gavrilova EV, Maksyutov RA, Ryzhikov AB. Severe cases of seasonal influenza in Russia in 2017—2018. PLoS One. 2019;14(7):e0220401. https://doi.org/10.1371/journal.pone.0220401
  13. Wedde M, Wählisch S, Wolff T, Schweiger B. Predominance of HA-222D/G polymorphism in influenza A(H1N1)pdm09 viruses associated with fatal and severe outcomes recently circulating in Germany. PLoS One. 2013;8(2):e57059. https://doi.org/10.1371/journal.pone.0057059
  14. Piralla A, Rovida F, Girello A, Premoli M, Mojoli F, Belliato M, et al. Frequency of respiratory virus infections and next-generation analysis of influenza A/H1N1pdm09 dynamics in the lower respiratory tract of patients admitted to the ICU. PLoS One. 2017;12(6):e0178926. https://doi.org/10.1371/journal.pone.0178926
  15. Selleri M, Piralla A, Rozera G, Giombini E, Bartolini B, Abbate I, et al. Detection of haemagglutinin D222 polymorphisms in influenza A(H1N1)pdm09-infected patients by ultra-deep pyrosequencing. Clin Microbiol Infect. 2013;19(7):668-673.  https://doi.org/10.1111/j.1469-0691.2012.03984.x
  16. Adlhoch C, Mook P, Lamb F, Ferland L, Melidou A, Amato-Gauci AJ, Pebody R; European Influenza Surveillance Network. Very little influenza in the WHO European Region during the 2020/21 season, weeks 40 2020 to 8 2021. Euro Surveill. 2021;26(11):2100221. https://doi.org/10.2807/1560-7917.ES.2021.26.11.2100221
  17. Kolosova NP, Ilyicheva TN, Unguryan VV, Danilenko AV, Svyatchenko SV, Onhonova GS, Goncharova NI, Kosenko MN, Gudymo AS, Marchenko VY, Shvalov AN, Susloparov IM, Tregubchak TV, Gavrilova EV, Maksyutov RA, Ryzhikov AB. Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021—2022. Pathogens. 2022;11(11):1388. https://doi.org/10.3390/pathogens11111388
  18. Kolosova NP, Ilyicheva TN, Svyatchenko SV, Danilenko AV, Onkhonova GS, Ivanova KI, Susloparov IM, Ryzhikov AB. Initial and severe cases of influenza in 2020-2022 and population immunity prior to epidemic season. Medical Immunology. 2022;24(6):1219-1226. (In Russ.). https://doi.org/10.15789/1563-0625-IAS-2513
  19. WHO. Consultation on the Composition of Influenza Virus Vaccines for Use in the 2023 Southern Hemisphere Influenza Season. https://www.who.int/news-room/events/detail/2022/09/19/default-calendar/who-e-consultation-on-the-composition-of-influenza-virus-vaccines-for-use-in-the-2023-southern-hemisphere-influenza-season
  20. WHO. Recommended Composition of Influenza Virus Vaccines for Use in the 2023 Southern Hemisphere Influenza Season. https://www.who.int/news/item/23-09-2022-new-recommendations-for-the-composition-of-influenza-vaccines-in-2023-for-the-southern-hemisphere
  21. Wille M, Holmes EC. The Ecology and Evolution of Influenza Viruses. Cold Spring Harb Perspect Med. 2020;10(7):a038489. https://doi.org/10.1101/cshperspect.a038489
  22. Nobusawa E, Sato K. Comparison of the mutation rates of human influenza A and B viruses. J Virol. 2006;80(7):3675-3678. https://doi.org/10.1128/JVI.80.7.3675-3678.2006
  23. Danilenko AV, Kolosova NP, Shvalov AN, Ilyicheva TN, Svyatchenko SV, Durymanov AG, Bulanovich JA, Goncharova NI, Susloparov IM, Marchenko VY, Tregubchak TV, Gavrilova EV, Maksyutov RA, Ryzhikov AB. Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018—2019. PLoS One. 2020;16(4):e0251019. https://doi.org/10.1371/journal.pone.0251019
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.