The authors analyzed diagnosis-related groups for malignant neoplasms at the expense of compulsory medical insurance fund in the Russian Federation for the period 2014—2021. Main steps of oncological diagnosis-related groups development are described authors emphasized the most significant changes in methodological approaches to assignment of hospital case to diagnosis-related group for inpatient and day hospitals. The number of diagnosis-related groups for payment of medical care for patients with malignancies was significantly increased over the period from 2014 to 2021. Due to the use of a differentiated approach to payment. Therefore, we can recognize a positive trend. Payment for cancer care within diagnosis-related group is differentiated depending on the stage of treatment and diagnostic process and in-hospital medical interventions. By 2021, coordination of tariffs with clinical guidelines is realized only in oncology although this coordination is partial.