OBJECTIVE
To analyze the values characterizing alcohol situation and incidence of cancer, as well as their interdependence among the population in the region of the Russian Federation in 2000-2018.
MATERIAL AND METHODS
This analysis is based on official federal and regional statistical data on alcohol sales, alcohol morbidity and newly diagnosed tumors. Determination coefficient (R2) was used for statistical analysis. Interdependence of alcohol situation and incidence of cancer was determined using correlation and regression analysis with calculation of regression coefficients, elasticity and non-parametric Spearman correlation with a lag ≥1 year.
RESULTS
Incidence of cancer has been significantly increased in the Mari El Republic for the period 2000-2018 (R2=0.85). Correlation between cancer de novo and sale of alcoholic beverages in alcohol equivalent per capita was observed year after year (r=0.53; CI 0.09-0.8, p=0.01). Nevertheless, the highest values (r=0.98) was found in a lag of 7 years and persisted until 12 years. In males, these values and lag were lower compared to females. Correlations between cancer and duration of «alcohol dependence syndrome» were established in a lag between oncological and alcoholic indicators within 1-6 years. Enhanced alcohol consumption proportionally increased incidence of cancer. Elastic dependence coefficient (Exi>1) was detected with a lag of 7-12 years.
CONCLUSION
Regional alcohol situation is significantly interrelated with overall oncological morbidity of the entire population and has a delayed long-term effect. One of the preventive measures against cancer is a targeted regulation of alcohol market.