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Kazakova P.O.

Pirogov Russian National Research Medical University

Petunina V.V.

Pirogov Russian National Research Medical University

Khamaganova I.V.

The Russian National Research Medical University named after N.I. Pirogov

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Peoples` Friendship University of Russia

Malyarenko E.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Denisova E.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Radionova E.E.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Shalaginova A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Evaluation of biochemical oncological markers and dermatoscopic picture in patients with tumor-associated localized scleroderma

Authors:

Kazakova P.O., Petunina V.V., Khamaganova I.V., Zhukova O.V., Malyarenko E.N., Denisova E.V., Radionova E.E., Shalaginova A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(2): 153‑159

DOI: 10.17116/klinderma202524021153

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Table of contents

EVALUATION OF BIOCHEMICAL ONCOLOGICAL MARKERS AND DERMATOSCOPIC PICTURE IN PATIENTS WITH TUMOR-ASSOCIATED LOCALIZED SCLERODERMA
EVALUATION OF BIOCHEMICAL ONCOLOGICAL MARKERS AND DERMATOSCOPIC PICTURE IN PATIENTS WITH TUMOR-ASSOCIATED LOCALIZED SCLERODERMA

To cite this article:

Kazakova PO, Petunina VV, Khamaganova IV, et al. . Evaluation of biochemical oncological markers and dermatoscopic picture in patients with tumor-associated localized scleroderma. Russian Journal of Clinical Dermatology and Venereology. 2025;24(2):153‑159. (In Russ.)
https://doi.org/10.17116/klinderma202524021153

 
Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

BACKGROUND

A special form of localized scleroderma (LS), namely tumor-associated LS, is distinguished. Some signs of LS may serve as an indicator of cancer in the body. They may occur before appearance of oncological diseases’ clinical symptoms. Identification of such signs will improve the survival of patients with cancer.

OBJECTIVE

To analyze the biochemical tumor markers and dermatoscopic picture in patients with tumor-associated LS.

MATERIAL AND METHODS

Patients (n=57) with histologically confirmed LS and excluded systemic scleroderma were divided into 2 groups depending on the presence of oncological diseases. Laboratory study of biochemical tumor markers (alpha-fetoprotein, CEA, NSE, CA 19-9, CA 72-4, CA 15-3) was performed, dermatoscopic diagnosis of the foci was done.

RESULTS

An increase in the level of oncomarkers has been found in 60% of patients with a cancer history and in 33.33% of patients without oncology. The increase of several indicators simultaneously has been mainly registered in patients with oncological history, whereas the increase of two cancer markers was found only in 1 (11.11%) patient in the group of subjects without oncology. It has been found in dermatoscopic examination that from 3 to 7 characteristic features were registered in the foci of patients without oncological history, while there were from 1 to 2 dermatoscopic signs of LS in all lesions in patients with oncology.

CONCLUSION

The risks associated with oncology in the management of patients with LS necessitate the identification of criteria for early diagnosis of the disease.

Keywords:

localized scleroderma
dermatoscopy
oncomarkers
paraneoplastic syndrome
morphea

Authors:

Kazakova P.O.

Pirogov Russian National Research Medical University

Petunina V.V.

Pirogov Russian National Research Medical University

Khamaganova I.V.

The Russian National Research Medical University named after N.I. Pirogov

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Peoples` Friendship University of Russia

Malyarenko E.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Denisova E.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Radionova E.E.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Shalaginova A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Received:

31.05.2024

Accepted:

28.01.2025

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