Civatte’s disease and vitiligo are chronic diseases accompanied by skin pigmentation disorder due to impaired melanogenesis under the influence of exogenous and endogenous factors. Among the external stimuli, excessive ultraviolet radiation exposure to photosensitizing chemicals may be a common factor in the above dyschromias. Such somatic diseases as systemic lupus erythematosus and autoimmune thyroid diseases are the most common among the endogenous causes of Civatte’s disease. In this regard, it is necessary to inform dermatologists about the possibility of associating these dermatoses with autoimmune pathology, to conduct a timely thorough examination of patients for the early detection of concomitant diseases. The therapy for Civatte’s disease and vitiligo aims to stabilize the process and ensure subsequent regression of clinical manifestations. However, the approach to treatment should be different due to the heterogeneity of the pathogenesis. Besides, when the response to the therapy is achieved, supportive treatment should be selected to avoid relapse. Here is a clinical case of the two dermatoses mentioned above in a 73-year-old patient. The clinical pattern of the conditions, laboratory methods, and instrumental examinations of the patient, as well as further tactics of its management and choice of therapy, are described.