Perioral dermatitis (PD), often referred to in the literature as steroid dermatitis because of the strong association between its occurrence and the use of topical glucocorticosteroids on the face, is a clinically characteristic and recognizable pattern of skin reaction manifested by erythema, papulopustular rash, and tight, dry skin. The disease is prone to chronicity and usually affects the perioral area (with a characteristic halo of intact skin on the contour of the lips) and, in rare cases, the perinasal and periocular areas. According to recent data, about 6% of women and 0.3% of men visiting dermatologists are diagnosed with perioral dermatitis; therefore, this disease is a very urgent problem in outpatient dermatology. However, this common inflammatory facial dermatosis is not well understood for etiopathogenesis and therapy approaches and requires more extensive and long-term research. Based on the analysis of domestic and foreign studies, this article presents the latest data on the etiology, pathogenesis, and treatment of perioral dermatitis, as well as a clinical case of the effective treatment of severe steroid dermatitis with topical ivermectin 1% cream.