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Sorokina K.I.

Ural state medical University Ministry of health of Russia

Ufimtseva M.A.

Ural state medical University

Simonova N.V.

Amur State Medical Academy

Beresneva T.A.

Yekaterinburg Medical Scientific Center for Prevention and Health Protection of Industrial Workers» of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Paskevich P.V.

Ural State Medical University

Topical enzymatic therapy of atrophic acne scars

Authors:

Sorokina K.I., Ufimtseva M.A., Simonova N.V., Beresneva T.A., Paskevich P.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2022;21(6): 840‑848

DOI: 10.17116/klinderma202221061840

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Table of contents

TOPICAL ENZYMATIC THERAPY OF ATROPHIC ACNE SCARS
TOPICAL ENZYMATIC THERAPY OF ATROPHIC ACNE SCARS

To cite this article:

Sorokina KI, Ufimtseva MA, Simonova NV, Beresneva TA, Paskevich PV. Topical enzymatic therapy of atrophic acne scars. Russian Journal of Clinical Dermatology and Venereology. 2022;21(6):840‑848. (In Russ.)
https://doi.org/10.17116/klinderma202221061840

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Background. Acne is a socially significant dermatological disease with a high prevalence among children and adults. After resolving inflammatory elements, a post-acne syndrome is formed, sometimes leading to an adverse outcome with scar deformities.

OBJECTIVE

To study the efficacy and safety of enzyme gel for treating atrophic acne scars.

MATERIALS AND METHODS

We conducted a longitudinal uncontrolled clinical study (before-after study) including 22 patients with a history of acne and post-inflammatory post-acne symptoms. The patients used a topical gel with an aqua complex of titanium glycerosolvate, collagenase and papain two times a day on the areas of the face with atrophic scars for 3 months with monthly follow-up examinations. Therapy efficacy was assessed at 3 months of using the gel (using the G.J. Goodman assessment scale and Manchester Scar Scale). The impact of post-acne syndrome on patients' quality of life was assessed using the Dermatological Quality of Life Index (DLQI).

RESULTS

The study gel application resulted in statistically significant differences in scar severity (G.J. Goodman scale, p<0.05) and assessment of clinical and functional parameters (Manchester Scar Scale, p<0.05). After the therapy, the patient survey showed an improvement in patients’ quality of life (DLQI, p<0.001).

CONCLUSION

The enzymatic gel showed significant effectiveness and safety in treating atrophic acne scars.

Keywords:

acne
post-acne syndrome
atrophic scars
collagenase
therapy

Authors:

Sorokina K.I.

Ural state medical University Ministry of health of Russia

Ufimtseva M.A.

Ural state medical University

Simonova N.V.

Amur State Medical Academy

Beresneva T.A.

Yekaterinburg Medical Scientific Center for Prevention and Health Protection of Industrial Workers» of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Paskevich P.V.

Ural State Medical University

Received:

02.11.2022

Accepted:

24.11.2022

Close metadata

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