Although no conditions fully reflecting the complex phenotype of psoriasis have been identified in laboratory animals, many spontaneous or genetically engineered mutations in rodents, immunological approaches, or xenotransplantation models have shed light on many aspects related to the pathophysiology and therapy of psoriasis. Animal models have helped elucidate the functions of inflammatory mediators, revealing the contribution of innate or adaptive immune mechanisms, as well as keratinocytes or endothelial cells, to the development and maintenance of inflammation in psoriasis. Experimental models of psoriasis could help in a deeper and more detailed study of pathogenetic mechanisms, the search for new therapeutic targets, and the development of new therapies. To date, of the many models of psoriasis, none are perfect. Therefore, future research should focus on further optimizing existing models and current strategies for their development. This article presents current models of psoriasis, provides their comparative characteristics, and evaluates their potential use for studying different aspects of psoriasis. Researchers are looking for an ideal animal model that would have maximum genetic, immunological, and morphological similarities to humans, would similarly respond to treatment, and, in addition, would be easily reproducible and cost-effective.