Effectiveness evaluation of the proactive maintenance therapy of atopic dermatitis in children using optical coherence tomography and skin ultrasound

Zainullina O.N.; Khismatullina Z.R.; Pechkurov D.V.

doi:https://doi.org/10.17116/klinderma20212002159

Zainullina O.N.

Bashkir State Medical University

ORCID: 0000-0002-6366-3595

Khismatullina Z.R.

Bashkir State Medical University, Russia

ORCID: 0000-0001-8674-2803

Pechkurov D.V.

Samara State Medical University

Effectiveness evaluation of the proactive maintenance therapy of atopic dermatitis in children using optical coherence tomography and skin ultrasound

Authors:

Zainullina O.N., Khismatullina Z.R., Pechkurov D.V.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2021;20(2): 59‑66

DOI: 10.17116/klinderma20212002159

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To cite this article:

Zainullina ON, Khismatullina ZR, Pechkurov DV. Effectiveness evaluation of the proactive maintenance therapy of atopic dermatitis in children using optical coherence tomography and skin ultrasound. Russian Journal of Clinical Dermatology and Venereology. 2021;20(2):59‑66. (In Russ.)
https://doi.org/10.17116/klinderma20212002159

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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OBJECTIVE

To study the effectiveness of proactive maintenance therapy of AD with the use of an ointment containing 0.03% tacrolimus in children using non-invasive instrumental research methods.

MATERIAL AND METHODS

The results of allergic dermatosis treatment in children with a topical calcineurin inhibitor have been analyzed. For this purpose an ointment containing 0.03% tacrolimus was used. Evaluation of the therapy effectiveness was carried out using the SCORAD scale and supplemented by optical coherence tomography and ultrasound examination of the skin. The study included 52 children with moderate AD; the main group consisted of 27 children who continued external therapy with an ointment containing 0.03% tacrolimus for a year after exacerbation finished; the comparison group included 25 children whose parents refused further proactive therapy.

RESULTS

It was shown while using an ointment containing 0.03% tacrolimus the SCORAD index in children of the main group became statistically lower than in children of the comparison group during the year (2.3±0.9 and 7.5±3.1 points respectively, p<0.05). During the observation period in the main group there were no cases of AD exacerbation; in the comparison group 13 (52.0%) children had relapses of the disease during this period. Clinically, children in the comparison group retained dry skin, lichenification, and itching. Instrumental research methods in dynamics showed the signs of the morphofunctional skin state normalization when using proactive therapy with an ointment containing 0.03% tacrolimus.

CONCLUSION

The use of an ointment containing 0.03% tacrolimus as a proactive maintenance therapy for atopic dermatitis in children can increase the duration of remission and is the prevention of disease recurrence. Assessment objectification of the skin condition by methods of optical coherence tomography and ultrasound skin examination will make it possible to monitor the treatment more accurately and carry out its correction.

Keywords:

atopic dermatitis

optical coherence tomography

tacrolimus

external therapy

skin ultrasound

Authors:

Zainullina O.N.

Bashkir State Medical University

ORCID: 0000-0002-6366-3595

Khismatullina Z.R.

Bashkir State Medical University, Russia

ORCID: 0000-0001-8674-2803

Pechkurov D.V.

Samara State Medical University

Received:

30.11.2020

Accepted:

29.01.2021

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