The prevalence of risk factors for development of melanoma among dermatological patients

Vakhitova I.I.; Michenko A.V.; Potekaev N.N.; Titov K.S.; Zhukova O.V.; Lvov A.N.

doi:https://doi.org/10.17116/klinderma202019051630

Vakhitova I.I.

Moscow Scientic and Practical Center of Dermatvenerology and Cosmetology

Michenko A.V.

Central State Medical Academy Department for Presidential Affairs of the Russian Federation;
Medical Research and Education Center of Lomonosov Moscow State University

ORCID: 0000-0002-2985-5729

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-9578-5490

Titov K.S.

Peoples’ Friendship University of Russia;
S.P. Botkin City Clinical Hospital

ORCID: 0000-0003-4460-9136

Zhukova O.V.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare;
Peoples’ Friendship University of Russia

ORCID: 0000-0001-5723-6573

Lvov A.N.

Central State Medical Academy Department for Presidential Affairs of the Russian Federation;
Medical Research and Education Center of Lomonosov Moscow State University

ORCID: 0000-0003-2737-3432

The prevalence of risk factors for development of melanoma among dermatological patients

Authors:

Vakhitova I.I., Michenko A.V., Potekaev N.N., Titov K.S., Zhukova O.V., Lvov A.N.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(5): 630‑636

DOI: 10.17116/klinderma202019051630

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To cite this article:

Vakhitova II, Michenko AV, Potekaev NN, Titov KS, Zhukova OV, Lvov AN. The prevalence of risk factors for development of melanoma among dermatological patients. Russian Journal of Clinical Dermatology and Venereology. 2020;19(5):630‑636. (In Russ.)
https://doi.org/10.17116/klinderma202019051630

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

It is known that dermatological patients receive pathogenic therapy (phototherapy, cytostatic, immunosuppressive and biological drugs), which may to be as an additional specific risk factor for the development of skin malignant neoplasms. However, prevalence of risk factors for development of melanoma in the population of dermatological patients in comparison with healthy volunteers has not been previously studied.

OBJECTIVE

To assess the prevalence of risk factors for melanoma development among dermatological patients in comparison with volunteers without skin disorders.

Material and methods: The main group included 413 dermatological outpatients and inpatients (268 of which were women (64.9%)) who visited Moscow Scientific Center of Dermatology, Venerology and Cosmetology; the control group included 249 healthy volunteers without dermatological disorders (197of which were women (79.11 %)). All participants filled in a questionnaire and clinical dermatological examination was conducted in order to identify the risk factors for skin melanoma development.

RESULTS

In dermatological patients, a higher prevalence of risk factors was revealed compared to the control group (p<0.05): male gender aged over 50 (OR 3.36); history of phototherapy (OR 22.51); more than 50 nevi on the skin of the body or more than 20 nevi on the skin of arms with a diameter of more than 2 mm (OR 1.68); congenital melanocytic nevi less than 1.9 cm (OR 6.36) and 2—19 cm in diameter (OR 6.30); skin photo-type I (OR 2.07); skin photo-type II (OR 6.17); signs of skin photo-damage (OR 2.33); combination of skin photo-type II with signs of photo-damage (OR 7.62).

CONCLUSION

In dermatological patients, the higher prevalence of several risk factors for the melanoma development was revealed in comparison with volunteers without skin disorders. These results suggest the necessity of a regular screening examination of dermatological patients with risk factors for the melanoma development by a dermatovenerologist.

Keywords:

melanoma

dysplastic nevus syndrome

FAMMM syndrome

risk factors

diagnosis of melanoma

dermatological patients

Authors:

Vakhitova I.I.

Moscow Scientic and Practical Center of Dermatvenerology and Cosmetology

Michenko A.V.

Central State Medical Academy Department for Presidential Affairs of the Russian Federation;
Medical Research and Education Center of Lomonosov Moscow State University

ORCID: 0000-0002-2985-5729

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-9578-5490

Titov K.S.

Peoples’ Friendship University of Russia;
S.P. Botkin City Clinical Hospital

ORCID: 0000-0003-4460-9136

Zhukova O.V.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare;
Peoples’ Friendship University of Russia

ORCID: 0000-0001-5723-6573

Lvov A.N.

Central State Medical Academy Department for Presidential Affairs of the Russian Federation;
Medical Research and Education Center of Lomonosov Moscow State University

ORCID: 0000-0003-2737-3432

Received:

05.03.2020

Accepted:

26.08.2020

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