Linear IgA-dependent bullous dermatosis is a rare immune-mediated vesical disease of skin that affects the skin and mucous tunics, is characterized by the appearance of subepidermal bullas induced by autoantibodies that are directed against several autoantigens with different molecular weights located in the area of the basement membrane of the multilayer squamose epithelium of skin and mucous tunics. There are 2 forms of the disease — childhood and adult, but their clinical difference is insignificant. In children, linear IgA-dependent bullous dermatosis was previously called childhood chronic bullous dermatosis. The adult form is usually observed in women after 60 years, often in patients with lymphoma, malignant neoplasia of the internal organs, as well as after taking certain medications. Dermatosis is associated with HLA-B8 in almost all patients, both children and adults. Initially, linear IgA-dependent dermatosis was considered one of the varieties of herpetiform dermatitis, however, at present, these diseases are clearly differ on the authority of immunopathological and immunogenetic signs, as well as in accordance of the absence of a stable association of linear dermatosis with glutensensitive enteropathy. There is a pronounced similarity of clinical and morphological manifestations with other bullous dermatoses (Dühring herpetiform dermatitis, acquired bullous epidermolysis, Lever bullous pemphigoid, bullous form of lichen planus, scarring pemphigoid), as a result of which diagnostic errors often occur. Thus, the significantly immunopathological picture of the disease, the linear IgA band in the area of the dermal-epidermal basement membrane, is guiding in the diagnosis verification. The clinical observation of rare dermatosis in a woman aged 82 years is described. Of particular interest is the identity of the clinical and morphological picture in this case with Dühring herpetiform dermatitis. The importance of using the immunofluorescence diagnostic method for timely verification of the diagnosis of linear IgA-dermatosis is emphasized. The awareness of practicing dermatologists about this disease contributes to early diagnosis, appropriate treatment and more favorable prognosis.