Atopic dermatitis is a multifactorial inflammatory skin disease characterized by itching, chronic relapsing course and age-related features of the localization and morphology of the lesion. Even though atopic dermatitis is one of the most common diseases, errors in the diagnosis and management of patients continue to occur. The purpose of the study is to increase knowledge on the diagnosis and management of patients with atopic dermatitis based on own clinical observations. Material and methods. Data of the use of topical treatment of atopic dermatitis are based on an analysis of 20 literature sources. The share of publications published over the past 10 years is 55%. Applied Internet search engines Google Scholar, eLibrary, Sigla. When describing clinical cases, the results of our own observations of patients and their photographs from the personal archive were used. Results. The article contains examples of errors in the diagnosis and management of patients with atopic dermatitis. The experience of treatment of such patients and clinical examples of the effectiveness of the treatment of atopic dermatitis using drugs of methylprednisolone aceponate, topical calcineurin inhibitors, emollients containing polyunsaturated omega-3-6-9 fatty acids are presented. Conclusion. The most common mistake is to diagnose atopic dermatitis in patients with enteropathic acrodermatitis and scabies. In the management of patients with atopic dermatitis, unreasonably prescribed inadequate doses of systemic corticosteroids for a long period, first-generation antihistamines, halogenated topical corticosteroids. Methylprednisolone aceponate and topical calcineurin inhibitors are the first-choice drugs in the treatment of exacerbations of atopic dermatitis, especially in childhood. The use of emollients based on physiological lipids helps to reduce the need for corticosteroids and prolong the remission of the disease.