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Sorokina K.N.

Ural State Medical University

Ufimtseva M.A.

Ural State Medical University;
Sverdlovsk Regional Skin and Venereological Dispensary

Shubina A.S.

Ural State Medical University

Beresneva T.A.

Sverdlovsk Regional Skin and Venereological Dispensary

Chokova A.M.

Ural State Medical University

The Effectiveness of Dermocosmetics for Skin Toxicity in Cancer Patients

Authors:

Sorokina K.N., Ufimtseva M.A., Shubina A.S., Beresneva T.A., Chokova A.M.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(6): 758‑764

DOI: 10.17116/klinderma202423061758

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Table of contents

THE EFFECTIVENESS OF DERMOCOSMETICS FOR SKIN TOXICITY IN CANCER PATIENTS
THE EFFECTIVENESS OF DERMOCOSMETICS FOR SKIN TOXICITY IN CANCER PATIENTS

To cite this article:

Sorokina KN, Ufimtseva MA, Shubina AS, Beresneva TA, Chokova AM. The Effectiveness of Dermocosmetics for Skin Toxicity in Cancer Patients. Russian Journal of Clinical Dermatology and Venereology. 2024;23(6):758‑764. (In Russ.)
https://doi.org/10.17116/klinderma202423061758

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

RELEVANCE

Targeted therapy is a key component of modern chemotherapy algorithms for cancer patients. Specific side effects related to the skin and its derivatives necessitate the study and development of dermatological control methods to preserve cancer therapy volume.

OBJECTIVE

To investigate the effectiveness of zinc-containing emollients and a healing balm in combined treatment of dermatological toxicity in cancer patients receiving EGFR inhibitors.

MATERIAL AND METHODS

This clinical cross-sectional study involved 115 patients who received cancer therapy with EGFR inhibitors exhibiting skin toxicity, zinc- and copper-containing emollients and a healing balm. The therapy effectiveness and the skin toxicity impact on the patient’s quality of life were assessed using the NCI-CTCAE V5.0 classification, the Visual Analogue Scale (VAS) for Pain, and the Dermatology Life Quality Index (DLQI).

RESULTS

The use of zinc-containing emollients and a healing balm for dermatological toxicity promoted a quicker clinical effect, reduced the severity of side effects, and improved the quality of life of cancer patients (DLQI, p<0.05).

CONCLUSION

The clinical effectiveness of zinc-containing emollients and a healing balm allows us to recommend them for treating skin toxicity in cancer patients receiving EGFR inhibitors as monotherapy or combined treatment regimens.

Keywords:

skin toxicity
EGFR inhibitors
emollients

Authors:

Sorokina K.N.

Ural State Medical University

Ufimtseva M.A.

Ural State Medical University;
Sverdlovsk Regional Skin and Venereological Dispensary

Shubina A.S.

Ural State Medical University

Beresneva T.A.

Sverdlovsk Regional Skin and Venereological Dispensary

Chokova A.M.

Ural State Medical University

Received:

11.09.2024

Accepted:

13.10.2024

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References:

  1. Semenkin AA, Sapronenko VS, Loginova EN, Nadey EV. Targeted therapy in oncology. Experimental and Clinical Gastroenterology. 2022;205(9):222-228. (In Russ.). https://doi.org/10.31146/1682-8658-ecg-205-9-222-228
  2. Andreev DA, Zav’yalov AA, Kokushkin KA, Davydovskaya MV. The application of the modern target medications for the treatment of metastatic colorectal cancer. Russian Journal of Evidence-Based Gastroenterology. 2018; 7(2):21-29. (In Russ.). https://doi.org/10.17116/dokgastro20187221
  3. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834.  https://doi.org/10.2174/1568026620666200303123102
  4. Morita M, Iizuka-Ohashi M, Watanabe M, et al. Oxidative stress induces EGFR inhibition-related skin cell death. J Clin Biochem Nutr. 2021;68(3): 235-242.  https://doi.org/10.3164/jcbn.20-112
  5. Li Y, Fu R, Jiang T, et al. Mechanism of Lethal Skin Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors and Related Treatment Strategies. Front Oncol. 2022;12:804212. Published 2022 Feb 10.  https://doi.org/10.3389/fonc.2022.804212
  6. Lacouture ME, Wainberg ZA, Patel AB, et al. Reducing Skin Toxicities from EGFR Inhibitors with Topical BRAF Inhibitor Therapy. Cancer Discov. 2021;11(9):2158-2167. https://doi.org/10.1158/2159-8290.CD-20-1847
  7. Richardson BN, Lin J, Buchwald ZS, Bai J. Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer: A Mini-Review. Front Oncol. 2022;12:924849. Published 2022 Jul 15.  https://doi.org/10.3389/fonc.2022.924849
  8. Dreno B, Khosrotehrani K, De Barros Silva G, Wolf JR, Kerob D, Trombetta M, Atenguena E, Dielenseger P, Pan M, Scotte F, Krakowski I, Lacouture M. The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus. Support Care Cancer. 2023;31(12):672. Published 2023 Nov 04.  https://doi.org/10.1007/s00520-023-08116-4
  9. Michenko AV, Kruglova LS, Shatokhina EA, Kononenko IB, Polonskaya AS, Romanov DV. Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction. Oncohematology. 2021;16(4):50-58. (In Russ.). https://doi.org/10.17650/1818-8346-2021-16-4-50-58
  10. Chiang TY, Hsu HC, Jane SW, Chen SC. EGFRI-associated health-related quality of life by severity of skin toxicity in metastatic colorectal cancer patients receiving epidermal growth factor receptor inhibitor target therapy. Support Care Cancer. 2020;28(10):4771-4779. https://doi.org/10.1007/s00520-020-05321-3
  11. Kafatos G, Dube S, Burdon P, et al. Management of EGFR Inhibitor-induced Skin Toxicity and Factors Impacting Patients’ Adherence to Skin Toxicity Treatment: Health Care Provider and Patient Surveys in European Oncology Centers. Clin Colorectal Cancer. 2020;19(2):100-108.e9.  https://doi.org/10.1016/j.clcc.2020.01.001
  12. Kruglova LS, Korolyova IA, Shatokhina EA. Prevention and therapy of acne-like rash in cancer patients receiving therapy with EGFR receptor inhibitors. Medical Alphabet. 2020;(24):42-46. (In Russ.). https://doi.org/10.33667/2078-5631-2020-24-42-46
  13. Koroleva IA, Bolotina LV, Gladkov OA, Gorbunova VA, Kogoniya LM, Kruglova LS, Manzyuk LV, Orlova RV, Orlova EV. Practical recommendations for drug treatment of dermatological reactions in patients receiving antitumor drug therapy. Malignant Neoplasms. 2022;12(3s2-2):101-122. (In Russ.). https://doi.org/10.18027/2224-5057-2022-12-3s2-101-122
  14. Raimondi A, Corallo S, Lonardi S, et al. Systemic doxycycline for pre-emptive treatment of anti-EGFR-related skin toxicity in patients with metastatic colorectal cancer receiving first-line panitumumab-based therapy: a post hoc analysis of the Valentino study. Support Care Cancer. 2021;29(7):3971-3980. PMID: 33392769. https://doi.org/10.1007/s00520-020-05972-2
  15. Freites-Martinez A, Santana N, Arias-Santiago S, Viera A. Using the Common Terminology Criteria for Adverse Events (CTCAE — Version 5.0) to Evaluate the Severity of Adverse Events of Anticancer Therapies. CTCAE versión 5.0. Evaluación de la gravedad de los eventos adversos dermatológicos de las terapias antineoplásicas. Actas Dermosifiliogr (Engl Ed). 2021; 112(1):90-92.  https://doi.org/10.1016/j.ad.2019.05.009
  16. Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI) — a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210-216. PMID: 8033378. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x
  17. Gélinas C, Puntillo KA, Levin P, Azoulay E. The Behavior Pain Assessment Tool for critically ill adults: a validation study in 28 countries. Pain. 2017; 158(5):811-821.  https://doi.org/10.1097/j.pain.0000000000000834
  18. Ifeanyichukwu UL, Fayemi OE, Ateba CN. Green Synthesis of Zinc Oxide Nanoparticles from Pomegranate (Punica granatum) Extracts and Characterization of Their Antibacterial Activity. Molecules. 2020;25(19):4521. Published 2020 Oct 02.  https://doi.org/10.3390/molecules25194521
  19. Al-Khafaji Z, Brito S, Bin BH. Zinc and Zinc Transporters in Dermatology. Int J Mol Sci. 2022;23(24):16165. Published 2022 Dec 18.  https://doi.org/10.3390/ijms232416165
  20. Haftek M, Abdayem R, Guyonnet-Debersac P. Skin Minerals: Key Roles of Inorganic Elements in Skin Physiological Functions. Int J Mol Sci. 2022; 23(11):6267. Published 2022 June 03.  https://doi.org/10.3390/ijms23116267
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