Modern studies demonstrate the multifactorial genesis of pruritus in patients with atopic dermatitis, which cast doubt on the use of antagonists of H1-receptors at the present stage. Study purpose — determination of the efficacy and tolerability of bilastine in the complex therapy of atopic dermatitis. Material and methods. The study included 60 patients with atopic dermatitis. All patients underwent examination (analysis of anamnesis data, determining the severity of atopic dermatitis, assessing the itching severity and recording adverse events). Formed 2 therapeutic groups. In the 1st group (n=30), traditional therapy was performed using basic skin care products, topical glucocorticosteroids of high potency were applied to the skin of the trunk and limbs, and a drug from the group of topical calcineurin inhibitors (tacrolimus) was applied to the skin of the face. In the 2nd group (n=30), in combination with the traditional therapy described above, the modern antihistamine drug bilastine was administered. The general course of therapy was 30 days. Results. The comparative study demonstrates the high efficacy and safety of bilastine in the treatment of atopic dermatitis in combination with the rational use of external treatment and basic care.