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Khardikova S.A.

Siberian State Medical University, Tomsk

Dmitruk V.S.

State educational institution of higher professional education "Siberian State Medical University", Russian Ministry of Health and Social Development, Tomsk

Modern aspects of topical therapy of atopic dermatitis in children (in Russian only)

Authors:

Khardikova S.A., Dmitruk V.S.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2019;18(1): 56‑63

DOI: 10.17116/klinderma20191801156

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MODERN ASPECTS OF TOPICAL THERAPY OF ATOPIC DERMATITIS IN CHILDREN (IN RUSSIAN ONLY)
MODERN ASPECTS OF TOPICAL THERAPY OF ATOPIC DERMATITIS IN CHILDREN (IN RUSSIAN ONLY)

To cite this article:

Khardikova SA, Dmitruk VS. Modern aspects of topical therapy of atopic dermatitis in children (in Russian only). Russian Journal of Clinical Dermatology and Venereology. 2019;18(1):56‑63. (In Russ.)
https://doi.org/10.17116/klinderma20191801156

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)
 
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Objective: to determine the effectiveness of sequential therapy of atopic dermatitis in children using 0.1% methylprednisolone aceponate in combination with ceramides and topical calcineurin inhibitor, tacrolimus ointment. Material and Methods. A total of 35 patients aged 2–16 years were examined. To assess the effectiveness of the therapy, the dermatological status was described in detail using the SCORAD index (1994), Dermatology Specific Quality of Life (DSQL) was determined before and after the therapy. Results. Therapy using 0.1% methylprednisolone aceponate in combination with ceramides and tacrolimus ointment showed excellent clinical efficacy in 32 (91.4%) patients, good, in 3 patients (8.6%), with no cases of satisfactory and unsatisfactory outcomes. The first clinical effect was noted already on the Day 2 after the start of the treatment. The therapy with 0.1% methylprednisolone aceponate cream in combination with ceramides and tacrolimus ointment was excellently tolerated by 34 (97.1%) patients and well tolerated by 1 patient (2.9%). No serious adverse events were reported during the study. Conclusions. The use of sequential therapy with 0.1% methylprednisolone aceponate cream in combination with ceramides and tacrolimus ointment allows for highly effective and safe local treatment in patients with atopic dermatitis.

Keywords:

atopic dermatitis
external therapy
clinical efficacy
safety

Authors:

Khardikova S.A.

Siberian State Medical University, Tomsk

Dmitruk V.S.

State educational institution of higher professional education "Siberian State Medical University", Russian Ministry of Health and Social Development, Tomsk

List of references:

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