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Kliuchareva S.V.

I.I. Mechnikov Sankt-Petersburg State Medical Academy

Sydikov A.A.

Gorodskoĭ kozhno-venerologicheskiĭ dispanser, Sankt-Peterburg

Chuprov I.N.

North-Western State Medical University by the name I.I. Mechnikov, St. Petersburg, Russia, 191015

Kasatkin E.V.

St. Petersburg GBUZ KVD №8, St. Petersburg, Russia, 195112

Givirovskiy S.E.

Sankt-Peterburgskij GBUZ KVD №8, Sankt-Peterburg, Rossija, 195112

Esavulova L.T.

Sankt-Peterburgskij GBUZ KVD №7, Sankt-Peterburg, Rossija, 198260

Baftalovskaya O.A.

St. Petersburg GBUZ KVD №7, St. Petersburg, Russia, 198260

Akhalaya M.R.

FBGUZ, №122 Hospital of L.G. Sokolov, the Central out-patient department, St. Petersburg, Russia, 194291

Human papillomavirus infection: current understanding of the pathogenesis and treatment

Authors:

Kliuchareva S.V., Sydikov A.A., Chuprov I.N., Kasatkin E.V., Givirovskiy S.E., Esavulova L.T., Baftalovskaya O.A., Akhalaya M.R.

More about the authors

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To cite this article:

Kliuchareva SV, Sydikov AA, Chuprov IN, et al. . Human papillomavirus infection: current understanding of the pathogenesis and treatment. Russian Journal of Clinical Dermatology and Venereology. 2018;17(1):94‑103. (In Russ.)
https://doi.org/10.17116/klinderma201817194-103

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References:

  1. Kirnbauer R, Lenz P. Human papillomaviruses. In: Bolognia JL, Jorizzo JL, Schaeffer JV, editors. Dermatology. 3rd ed. China: Elsevier; 2012;1303-1319.
  2. Kubanova AA, Kubanov AA, Zaslavsky DV, et al. Maintaining patients with STD and urogenital infections (clinical recommendations). М. 2012;13. (In Russ.)
  3. Mascaro JM, Mascaro Jr JM. Warts and condylomas. In: Katsambas AD, Lotti TM, editors. European handbook of dermatological treatments. 2nd ed. Berlin: Springer; 2003;575-579.
  4. Meyer T, Arndt R, Christophers E, et al. Association of rare human papillomavirus types with genital premalignant and malignant lesions. J Infec Dis. 1998;178:252-255.
  5. Brown DR, Schroeder JM, Bryan JM, Stoler MH, Fife KH. Detection of multiple human papillomavirus types in condylomata acuminata lesions from otherwise healthy and immunosuppressed patients. J Clin Microbiol. 1999;37:3316-3322.
  6. Sterling JC. Virus infections. In: Burns T, Breathnach S, Cox N, Griffi ths C, editors. Rook’s textbook of dermatology 8th ed. Singapore: Wiley-Blackwell; 2010;33:37-60.
  7. Burchell AN, Winer RL, Sanjose S, Franco EL. Epidemiology and transmission dynamics of genital HPV infection. Vaccine. 2006;24:S3:52-61.
  8. Oriel JD. Natural history of genital warts. Br J Vener Dis. 1971;47:1-13.
  9. Zur Hausen H. Human pathogenic papillomaviruses, topics in microbiology and immunology. Berlin. 1994;186:131-157.
  10. Stone KM. Human papillomavirus and genital warts: update on epidemiology and treatment. Clin Infect Dis. 1995;20:91-97.
  11. Cook LS, Koutsky LA, Holmes KK. Clinical presentation of genital warts among circumcised and uncircumcised heterosexual men attending an urban STD clinic. Genitourin Med. 1993;69:262-264.
  12. Sonnex C, Schofield JH, Kocjan G, et al. Anal human papillomavirus infection in heterosexuals with genital warts: prevalence and relation with sexual behaviour. Brit Med J. 1991;303:1243.
  13. Rodionov AN, Zaslavsky DV, Chuprov IN, Nasyrov RA, Zaytsev VS, Ibragimov KU, Sidikov AA, Skrek SV. Dermatopatologiya of inflammatory diseases of skin. Tashkent. 2014;208. (In Russ.)
  14. Zaslavsky DV, Chuprov IN, Sidikov AA, Wolkenstein Pierre, Sadykov AI, Sibgatullin RR, Koval YuG, Skrek SV. Use of medicine imiquimod in a dosage form cream of 5% in therapy of basal cell carcinoma. Vestn Dermatol venerol. 2015;6:67-74. (In Russ.)
  15. Liota E, Smith KJ, Buckley R, Menon P, Skelton H. Imiquimod therapy for molluscum contagiosum. J Cutan Med Surg. 2000;4:76-82.
  16. Dytoc M, Wat H, Cheung-Lee M, Sawyer D, Ackerman T, Fiorillo L. Evaluation of the efficacy and safety of topical imiquimod 5% for plaque-type morphea: a multicenter, prospective, Vehicle-Controlled Trial. J Cutan Med Surg. 2015; Mar 11. pii: 7750.2014.14072
  17. Ackenzie-Wood A, Kossard S, De Launey J, Wilkinson B. Owens Ml. Imiquimod 5% cream in the treatment of Bowen’s disease. J Am Acad Dermatol. 2001;44:462-470.
  18. Megyeri K, Au W-C, Rosztoczy I, et al. Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways. Mol Cell Biol. 1995;15:2207-2218.
  19. Gibson SJ, Imbertson LM, Wagner TL, et al. Cellular requirements for cytokine induction in response to the immunomodulators imiquimod and S-27609. Interferon Cytokine Res. 1995;15:537-545.
  20. Testerman TL, Gerster JF, Imbertson LM, et al. Cytokine induction by the immunomodulators imiquimod and S-27609. J Leukoc Biol. 1995;58:365-372.
  21. Sauder D.N. Immunomodulatory and pharmacologic properties of imiquimod. J Am Acad Dermatol. 2000;43:6-11.
  22. Gibson S, Lind J, Riter T, et al. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cellular Immunol. 2002;218(1-2):74-86.
  23. Wang B, Shivji GM, et al. Imiquimod, a topical immune response modifier, induces migration of Langerhans cells. J Invest Dermatol. 2000;114:135-141.
  24. Khryanin AA, Klyuchayerva SV, Baftalovskaya OA, Lobzev NV, Pershchestkaya EB. Vestn Dermatol Venerol. 2015;5:134-142. (In Russ.)
  25. Tyring SK, Arany I, Stanley MA. A randomized, controlled, molecular study of condylomata acuminate clearance drug treatment with imiquimod. J Infect Dis. 1998;178:551-555.
  26. Miller RL, Gerster JF, Owens MA, et al. Imiquimod applied topically: a novel immune response modifier and new class of drag. Int J Immunopharmacol. 1999;21:1-14.
  27. Stone KM. Human papillomavirus and genital warts: update on epidemiology and treatment. Clin Infect Dis. 1995;20:91-97.
  28. Heaton CL. Clinical manifestations and modern management of condylomata acuminate: a dermatologic perspective. Am J Obstet Gynecol. 1995;172:1345-1350.
  29. Bashi SA. Cryotherapy versus podophyllin in the treatment of genital warts. J Int Dermatol. 1985;24:535-536.
  30. Godley M, Bradbeer C, Gellan M, Thin RN. Cryotherapy compared with trichlor acetatic acid in treating genital warts. Genitourin Med. 1987;63:390-392.
  31. O’Mahony C, Law C, Gollnick HPM et al. Patients attitudes to genital wart therapies. Int J STD & AIDS. 2001;12:567-570.
  32. Rakhmatulina MR, Kubanov AA, Samtsov AV, et al. Clinical efficiency, safety and tolerance of Keravort cream (imiquimod) in therapy of anogenital warts. Vestn Dermatol Venerol. 2015;1:126-130. (In Russ.)
  33. Rakhmatulina MR, Semenenko AV. Comparative analysis of methods of diagnostics and therapy of clinical displays of a human papillomavirus infection. Vestn Dermatol Venerol. 2015;1:46-53. (In Russ.)
  34. Krogh von G, Lacey CJN, Gross G, et al. European course on HPV associated pathology. Sex Transm Inf. 2000;76:162-168.
  35. European STD. Guidelines Int J STD AIDS. 2001;12(suppl 3):722-729.
  36. CDC Recommendations and reports. 2002;5 1:RR-6:53-57.
  37. Klinicheskie rekomendacii RODVK. Vedenie bolnyh IPPP i urogenitalnymi infekciyami. M. 2013 (In Russ.)
  38. Lacey CJN, Woodhall SC, Wikstrom A, Ross J. European guideline for the management of anogenital warts. J Eur Acad Dermatol Venereol. 2013;27(3):e263-e270.
  39. Schön MP, Schön M. Imiquimod: mode of action. Br J Dermatol. 2007;157(Suppl s2):8-13.
  40. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines 2010 CDC. MMWR Recomm Rep. 2010;59:1-110.

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