Damage to the integrity of the epidermal barrier in patients with atopic dermatitis is accompanied by increased trans-epidermal water loss, dry skin, and increased sensitivity to irritants and infectious agents, which necessitates administration of emollients, a large and diverse category of cosmeceutics. Among the wide variety of emollients on the pharmaceutical market, Topicrem AD Emollient Oil is a novel product (Laboratoires Nigy, France), which opens the possibilities for a unique effect on dry skin, restoring the water-lipid balance of the epidermis. It can be used as an emollient in the regions with hot climate, since it was developed in an innovative galenic form, which is a special feature of this product. Microemulsion has an oily texture, but it is rapidly absorbed like a gel and leaves no sticky or oily film. We studied the efficacy and safety of the topical product Topicrem AD Oil in the combination therapy of 44 patients with mild to moderate atopic dermatitis. The use of Topicrem AD Oil in the combination therapy decreases the duration of treatment and therefore reduces the time of administration of topical glucocorticosteroids (TGCS) and calcineurin inhibitors (CI), extends the period of remission, protects from secondary bacterial microflora, and improves quality of life of patients and their parents. In summary, the use of Topicrem AD Oil in the complex treatment had a significant positive impact on skin condition and quality of life of patients who participated in the study. There was positive dynamics of atopic dermatitis severity index. The results of our study allow us to recommend Topicrem AD Oil in the treatment of patients with atopic dermatitis in summer.