Treatment of psoriasis is still a topical issue, especially in patients with somatic diseases, among which metabolic syndrome and associated overweight play and important role. Objective — the study was aimed at evaluating the effectiveness of the developed integrated treatment using narrowband phototherapy and metformin in overweight patients with plaque psoriasis. Material and methods. We examined and treated 113 overweight patients with plaque psoriasis (including 75 females and 38 males aged 21—57 years). We developed an integrated treatment, which included narrowband phototherapy at 311 nm and metformin along with conventional therapy. Treatment results were evaluated in three groups: group 1 patients (n=36) received conventional treatment, in group 2 patients (n=38) conventional therapy was used in combination with narrowband phototherapy, and group 3 patients (n=39) received narrowband phototherapy and metformin along with conventional therapy. Treatment efficacy was assessed based on the dynamics of dermatological indexes: quality of life (DLQI) and PASI. The research results were processed statistically using standard programs. Results. It was shown that PASI decreased by 75% after 4 weeks of treatment in 17 (47.28%) group 1 patients, 26 (68.4%) group 2 patients, and in 32 (82.1%) group 3 patients. DLQI decreased from 19.6±2.1 to 2.6±0.8 points in group 1, from 19.1±2.4 to 2.2±0.7 points in group 2, and from 19.1±2.3 to 1.9±0.7 points in group 3 patients (p≤0.05). Clinical remission during 2 years was observed in 16 (44.4%) group 1 patients, 20 (52.6%) group 2 patients, and 34 (87.2%) group 3 patients. Conclusions. We designed an integrated treatment of overweight patients with plaque psoriasis, including narrowband phototherapy and metformin along with conventional therapy, which is highly effective, contributes to more pronounced and persistent clinical effect, significantly improves the quality of life of patients, and may be the treatment of choice in dermatological practice.