Objective. The study is aimed at assessing the effectiveness of 2% sertaconazole cream compared to 1% clotrimazole cream and 1% terbinafine cream in patients with tinea pedis. Material and methods. We examined and treated 76 patients with confirmed (microscopy, bacteriological test) diagnosis of tinea pedis. Monitoring of patients complied with the standards appropriate for this disease and included objective research methods: microscopy/bacterial inoculation, clinical methods, VAS index (erythema, infiltration, desquamation, cracks, itching, tenderness) and DLQI index. Results. It has been shown that application of 2% sertaconazole cream results in clinical and laboratory cure in 100% of the patients, regardless of the type of fungus. Positive dynamics of the skin process is accompanied by improvement of the quality of life of patients. Long-term follow-up results (6 months) showed no recurrence. Conclusions. Sertaconazole in the form of 2% topical cream is highly effective topical tool in treatment and prevention of recurrences of tinea pedis, regardless of the type of pathogen, including fungal strains resistant to some antifungal agents.