Mutations in the fillagrin gene as a factor predisposing to the development of atopic dermatitis

Salikova T.I.; Maksimov V.N.; Maksimova Iu.V.; Allakhverdian A.A.; Klimov V.V.; Denisov A.A.; Koshovkina T.V.

doi:https://doi.org/

Salikova T.I.

Siberian State Medical University, Tomsk

Maksimov V.N.

Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

Maksimova Iu.V.

Novosibirsk State Medical University

Allakhverdian A.A.

Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

Klimov V.V.

Siberian State Medical University, Tomsk

Denisov A.A.

Siberian State Medical University, Tomsk

Koshovkina T.V.

Siberian State Medical University, Tomsk

Mutations in the fillagrin gene as a factor predisposing to the development of atopic dermatitis

Authors:

Salikova T.I., Maksimov V.N., Maksimova Iu.V., Allakhverdian A.A., Klimov V.V., Denisov A.A., Koshovkina T.V.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2010;8(3): 4‑7

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To cite this article:

Salikova TI, Maksimov VN, Maksimova IuV, Allakhverdian AA, Klimov VV, Denisov AA, Koshovkina TV. Mutations in the fillagrin gene as a factor predisposing to the development of atopic dermatitis. Russian Journal of Clinical Dermatology and Venereology. 2010;8(3):4‑7. (In Russ.)

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Atopic dermatitis (AD) develops in genetically predisposed subjects. The causative genes differ in individual patients which suggests genetic heterogeneity of the disease. This paper reports a clinical case presenting with one of the genetic factors predisposing to AD, namely a failure of skin barrier function underlain by mutations in the fillagrin gene. These genetic defects are responsible for enhanced permeability of the skin for allergens while epicutaneous sensitization promotes the development of atopic dermatitis. It is proposed that medicines promoting recovery of the skin barrier and inhibiting allergen penetration should be introduced in the combined treatment of patients with AD for primary and secondary prophylaxis of the disease.

Keywords:

atopic dermatitis

genetics

fillagrin

skin barrier

Authors:

Salikova T.I.

Siberian State Medical University, Tomsk

Maksimov V.N.

Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

Maksimova Iu.V.

Novosibirsk State Medical University

Allakhverdian A.A.

Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

Klimov V.V.

Siberian State Medical University, Tomsk

Denisov A.A.

Siberian State Medical University, Tomsk

Koshovkina T.V.

Siberian State Medical University, Tomsk

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