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Sergeev A.V.

Sechenov First Moscow State Medical University (Sechenov University)

Guziy E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Kovalchuk N.A.

Sechenov First Moscow State Medical University (Sechenov University)

Sokolov E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Ostroukhova I.O.

Lomonosov Moscow State University

Rudko O.I.

Lomonosov Moscow State University

Tabeeva G.R.

Sechenov First Moscow State Medical University (Sechenov University)

The role of dopaminergic genes in chronic migraine and medication-overuse headache

Authors:

Sergeev A.V., Guziy E.A., Kovalchuk N.A., Sokolov E.A., Ostroukhova I.O., Rudko O.I., Tabeeva G.R.

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Journal: Russian Journal of Pain. 2024;22(4): 24‑29

DOI: 10.17116/pain20242204124

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To cite this article:

Sergeev AV, Guziy EA, Kovalchuk NA, Sokolov EA, Ostroukhova IO, Rudko OI, Tabeeva GR. The role of dopaminergic genes in chronic migraine and medication-overuse headache. Russian Journal of Pain. 2024;22(4):24‑29. (In Russ.)
https://doi.org/10.17116/pain20242204124

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The role of dopaminergic system in prodromal and postdromal symptoms of migraine attack, as well as modulation of trigeminovascular system was established. Activity of dopaminergic complex (dopamine-β-hydroxylase, dopamine receptors and transporters) has a genetic predisposition. The role of dopaminergic system gene polymorphism in various forms of migraine and drug-induced headache was studied. There are significant correlations between AA variant of rs2097629 single nucleotide polymorphism (SNP) of DBH gene and risk of drug-induced headache, chronic migraine, anxiety disorders and depression, as well as impulsive intake of analgesics. CC variant of rs6275 SNP of DRD2 gene is significantly associated with high P100 amplitude and phenomenon of dishabituation. This can indicate the influence of dopaminergic system on cortical hyperexcitability and thalamocortical dysrhythmia.

Keywords:

chronic migraine
medication-overuse headache
genetics
dopamine-β-hydroxylase (DBH)
catechol-O-methyltransferase (COMT)

Authors:

Sergeev A.V.

Sechenov First Moscow State Medical University (Sechenov University)

Guziy E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Kovalchuk N.A.

Sechenov First Moscow State Medical University (Sechenov University)

Sokolov E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Ostroukhova I.O.

Lomonosov Moscow State University

Rudko O.I.

Lomonosov Moscow State University

Tabeeva G.R.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

06.09.2024

Accepted:

01.10.2024

List of references:

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