Human skin performs many functions, including protection of the body from external factors and irritants. These factors affect the skin’s characteristics, in particular its response to changes in temperature and humidity of the air. Studies on the effect of conditions with low relative air humidity on skin are limited. They show that such conditions adversely affect the skin, transepidermal water loss enhances, risk of developing allergic reactions increases. Most often such negative influence was studied in persons with existing dermatological conditions. Nevertheless, characteristics of healthy skin deteriorate under adverse external conditions as well, it is observed especially often in winter, from exposure not only to cold air on the street, but also to dry indoor air. It has been shown that a 6-hour stay in winter in the dry office causes an increase of skin temperature, redness, enhances skin microrelief intensity and transepidermal water loss. These effects lead to skin barrier disruption, but as some studies show, lipid-replenishing skincare products can improve the skin barrier function that is affected by adverse climatic factors. The replacement of lipids deficiency will contribute to the restoration of skin barrier considering that stratum corneum is mainly consisted of lipid structures. In particular, products containing such components as fatty acids (oleic, linoleic and etc.) and softening agents may be used to eliminate unpleasant sensations and symptoms caused by dry and/or cool air, low temperatures and other adverse climatic factors.