Influence of non-opiate analgesia on postoperative pain intensity and patient satisfaction

Butyrsky A.G.

Vernadsky Crimean Federal University

ORCID: 0000-0001-5415-3756

Mikhailichenko V.Yu.

Vernadsky Crimean Federal University

ORCID: 0000-0003-4204-5912

Bozhko M.M.

Municipal Clinical Emergency Hospital No. 6

ORCID: 0000-0001-7288-4368

Ametov A.U.

Municipal Clinical Emergency Hospital No. 6

ORCID: 0000-0001-8868-5902

Bobkov O.V.

Vernadsky Crimean Federal University

Butyrskaya I.B.

Vernadsky Crimean Federal University

ORCID: 0000-0002-4283-2572

Bobkov N.O.

Vernadsky Crimean Federal University

ORCID: 0009-0002-7950-6356

Influence of non-opiate analgesia on postoperative pain intensity and patient satisfaction

Authors:

Butyrsky A.G., Mikhailichenko V.Yu., Bozhko M.M., Ametov A.U., Bobkov O.V., Butyrskaya I.B., Bobkov N.O.

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Journal: Pirogov Russian Journal of Surgery. 2024;(12): 74‑80

DOI: 10.17116/hirurgia202412174

Downloaded: 6

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To cite this article:

Butyrsky AG, Mikhailichenko VYu, Bozhko MM, Ametov AU, Bobkov OV, Butyrskaya IB, Bobkov NO. Influence of non-opiate analgesia on postoperative pain intensity and patient satisfaction. Pirogov Russian Journal of Surgery. 2024;(12):74‑80. (In Russ.)
https://doi.org/10.17116/hirurgia202412174

Подписка 2025-2 (Pirogov Russian Journal of Surgery)

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OBJECTIVE

To compare the results of postoperative opiate and non-opiate analgesia.

MATERIAL AND METHODS

The study was carried out as a part of the OPERAS global trial. Analysis was conducted in accordance with the STROBE reporting guidelines for observational studies. A prospective cohort study included data of patients after emergency and elective abdominal surgery. Primary outcomes were duration of severe pain and patient satisfaction with pain relief during the first week after surgery. Data were collected through review of case reports and interviews with patients one week after surgery.

RESULTS

The study involved 173 postoperative patients. Opioid analgesia after surgery was prescribed in 52 patients (30.1 %); 10% of patients reported severe pain within the first week after surgery and rated satisfaction with analgesia as 90 out of 100 points. After adjusting for confounders, opiate analgesia was independently associated with higher pain (hazard ratio 1.52, 95% CI 1.31 to 1.76; p<0.001) and need for medical care for drug-related side effects (OR 2.38, 95% CI 1.36 to 4.17; p=0.004). Opiate analgesia was not associated with satisfaction with analgesia (β coefficient 0.92, 95% CI –1.52 to 3.36; p=0.468) compared to non-opiate analgesia.

CONCLUSION

Postoperative opiate analgesia is associated with higher risk of drug-related side effects and aggravation of pain, but not with changes in satisfaction with pain relief. Non-opiate analgesia should be used regularly after surgery.

Keywords:

surgery

postoperative period

pain relief

opiate and non-opiate analgesics

Authors:

Butyrsky A.G.

Vernadsky Crimean Federal University

ORCID: 0000-0001-5415-3756

Mikhailichenko V.Yu.

Vernadsky Crimean Federal University

ORCID: 0000-0003-4204-5912

Bozhko M.M.

Municipal Clinical Emergency Hospital No. 6

ORCID: 0000-0001-7288-4368

Ametov A.U.

Municipal Clinical Emergency Hospital No. 6

ORCID: 0000-0001-8868-5902

Bobkov O.V.

Vernadsky Crimean Federal University

Butyrskaya I.B.

Vernadsky Crimean Federal University

ORCID: 0000-0002-4283-2572

Bobkov N.O.

Vernadsky Crimean Federal University

ORCID: 0009-0002-7950-6356

Received:

06.03.2024

Accepted:

10.04.2024

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