Results of redo liver resections for metastatic colorectal cancer

Kit O.I.

National Medical Oncology Research Center

ORCID: 0000-0003-3061-6108

Gevorkyan Yu.A.

National Medical Research Center for Oncology

Soldatkina N.V.

National Medical Research Center for Oncology

Dashkov A.V.

National Medical Research Center for Oncology

Kolesnikov V.E.

National Medical Research Center for Oncology

Bondarenko O.K.

National Medical Research Centre for Oncology

Khabzhokov E.K.

National Medical Research Centre for Oncology

Results of redo liver resections for metastatic colorectal cancer

Authors:

Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., Dashkov A.V., Kolesnikov V.E., Bondarenko O.K., Khabzhokov E.K.

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Journal: Pirogov Russian Journal of Surgery. 2022;(8): 45‑52

DOI: 10.17116/hirurgia202208145

Downloaded: 30

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To cite this article:

Kit OI, Gevorkyan YuA, Soldatkina NV, Dashkov AV, Kolesnikov VE, Bondarenko OK, Khabzhokov EK. Results of redo liver resections for metastatic colorectal cancer. Pirogov Russian Journal of Surgery. 2022;(8):45‑52. (In Russ.)
https://doi.org/10.17116/hirurgia202208145

Подписка 2025-2 (Pirogov Russian Journal of Surgery)

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OBJECTIVE

To analyze patients undergoing redo liver resections for metastatic colorectal cancer.

MATERIAL AND METHODS

The study included 14 patients with colorectal cancer who underwent several redo liver resections for metastatic lesions between September 2011 and June 2021. Mean age of patients was 63.5 years. Left-sided colonic G2 adenocarcinoma T4N1-2 prevailed (wild-type KRAS).

RESULTS

Fourteen patients (100%) underwent two liver resections, 7 (50%) — three resections, 1 (7.1%) — four resections. Mean period between the first and the second liver resections was 16.2 months, between the second and the third resections — 9.9 months, between the third and the fourth resections — 5 months. Maximum follow-up period after primary surgery was 9 years and 9 months. Seventy-five percent of patients were alive after 34.2 months, 50% — after 58.9 months. N+ status of colorectal tumor decreased survival while KRAS mutation and synchronous metastatic liver lesions increased survival.

CONCLUSION

Redo liver resections for metastatic colorectal cancer are safe and ensure favorable long-term survival in certain patients.

Keywords:

liver metastases

colorectal cancer

redo liver resections

prognostic factors

results

Authors:

Kit O.I.

National Medical Oncology Research Center

ORCID: 0000-0003-3061-6108

Gevorkyan Yu.A.

National Medical Research Center for Oncology

Soldatkina N.V.

National Medical Research Center for Oncology

Dashkov A.V.

National Medical Research Center for Oncology

Kolesnikov V.E.

National Medical Research Center for Oncology

Bondarenko O.K.

National Medical Research Centre for Oncology

Khabzhokov E.K.

National Medical Research Centre for Oncology

Received:

02.12.2021

Accepted:

16.01.2022

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