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Gaas M.Ya.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Radiology Research Center;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Kostin A.A.

Peoples’ Friendship University of Russia (RUDN University)

Vorobyev N.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kalpinskiy A.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Sorochinskiy N.A.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Negmatova M.Kh.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Zubayraeva A.A.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Surgical management of patients with local recurrence of renal cancer. Prognostic factors of survival

Authors:

Gaas M.Ya., Kaprin A.D., Kostin A.A., Vorobyev N.V., Kalpinskiy A.S., Sorochinskiy N.A., Negmatova M.Kh., Zubayraeva A.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(3): 20‑24

DOI: 10.17116/onkolog20251403120

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Table of contents

SURGICAL MANAGEMENT OF PATIENTS WITH LOCAL RECURRENCE OF RENAL CANCER. PROGNOSTIC FACTORS OF SURVIVAL
SURGICAL MANAGEMENT OF PATIENTS WITH LOCAL RECURRENCE OF RENAL CANCER. PROGNOSTIC FACTORS OF SURVIVAL

To cite this article:

Gaas MYa, Kaprin AD, Kostin AA, et al. . Surgical management of patients with local recurrence of renal cancer. Prognostic factors of survival. P.A. Herzen Journal of Oncology. 2025;14(3):20‑24. (In Russ.)
https://doi.org/10.17116/onkolog20251403120

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Treatment of local recurrence of renal cell carcinoma (RCC) is a serious surgical and therapeutic problem. Currently, there is no single standardized treatment strategy for patients in this group.

OBJECTIVE

Determination of prognostic factors for overall and tumor-specific survival (OS and NSV, respectively) of patients after surgical treatment for RCC local recurrence to assess its efficacy.

MATERIAL AND METHODS

From May 2007 to April 2024, 53 patients with local recurrence of RCC were operated on in the oncourology department of the P.A. Herzen Moscow Oncology Research Institute. Of them, 18 (34%) were operated on for primary kidney tumor (12 cases underwent nephrectomy, 6 –kidney resection) at the P.A. Herzen Moscow Scientific Research Institute, 35 (66%) — at their place of residence (16 underwent nephrectomy, 14 — kidney resection, 5 — radiofrequency thermoablation). During single- and multivariate analyses of a number of pre- and intraoperative parameters, as well as the results of pathomorphological examination, the main prognostic factors of overall (OS) and cancer-specific survival (CSS) of patients were determined.

RESULTS

In multivariate analysis, the most significant factors for OS were the number of tumor nodes (HR=3.201, p=0.003), microvascular invasion (HR=103.330, p=0.002), and for CSS — the number of recurrent tumor nodes (HR=3.201, p=0.003) and high tumor malignancy (G3—4) (HR=6.304, p=0.025).

CONCLUSION

The distant oncologic outcomes of surgical treatment of patients with local recurrence of RCC are influenced by a number of factors: microvascular invasion of the tumor, the number of recurrent tumor nodes, and the high degree of tumor malignancy.

Keywords:

renal cell carcinoma
local recurrence
prognostic factors
surgical treatment of locally recurrent renal cell carcinoma

Authors:

Gaas M.Ya.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Radiology Research Center;
P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Kostin A.A.

Peoples’ Friendship University of Russia (RUDN University)

Vorobyev N.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kalpinskiy A.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Sorochinskiy N.A.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Negmatova M.Kh.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Zubayraeva A.A.

Peoples’ Friendship University of Russia named after Patrice Lumumba

Received:

28.11.2024

Accepted:

13.03.2025

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References:

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