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Aliev S.A.

Azerbaijan Medical University

Aliev É.S.

Azerbaijan Medical University

Colorectal cancer liver metastases: current state of the problem, priority treatment approaches

Authors:

Aliev S.A., Aliev É.S.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(5): 111‑119

DOI: 10.17116/hirurgia2022051111

Read: 3283 times

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Table of contents

COLORECTAL CANCER LIVER METASTASES: CURRENT STATE OF THE PROBLEM, PRIORITY TREATMENT APPROACHES
COLORECTAL CANCER LIVER METASTASES: CURRENT STATE OF THE PROBLEM, PRIORITY TREATMENT APPROACHES

To cite this article:

Aliev SA, Aliev ÉS. Colorectal cancer liver metastases: current state of the problem, priority treatment approaches. Pirogov Russian Journal of Surgery. 2022;(5):111‑119. (In Russ.)
https://doi.org/10.17116/hirurgia2022051111

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The review is devoted to the world trends in epidemiology of colorectal cancer and treatment of colorectal cancer liver metastases. The authors analyze the effectiveness of traditional (resection) and modern minimally invasive methods of local destruction (radiofrequency thermoablation, microwave ablation, cryoablation), stereotactic radiotherapy, radiosurgery, targeted therapy and endovascular techniques (chemoinfusion, chemoembolization, radioembolization). It was emphasized that searching for new chemotherapeutic and targeted drugs is one of the reserve ways to improve treatment outcomes in patients with potentially resectable colorectal cancer liver metastases. The possibilities and prospects of liver transplantation as a priority treatment strategy for patients with unresectable bilobar colorectal cancer liver metastases are highlighted.

Keywords:

colorectal cancer
liver metastases
multiple bilobar unresectable metastases
minimally invasive methods of local treatment
liver transplantation

Authors:

Aliev S.A.

Azerbaijan Medical University

Aliev É.S.

Azerbaijan Medical University

Received:

04.06.2021

Accepted:

02.08.2021

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References:

  1. Aliev FSh, Desyatov EN, Krytskik AG, Aliev VF, Leimanchenko PI. The epidemiology of colorectal cancer: world and regional tendencies. Problems in Oncology. 2016;4(88):126-128. (In Russ.).
  2. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683-691.  https://doi.org/10.1136/gutjnl-2015-310912
  3. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbax T, Levin ThR, Liebarman D, Robertson DJ. Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer Gastrointestinal Endosc. 2017;86(1):18-33.  https://doi.org/10.1016/j.gie.2017.04.003
  4. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019; 14(2):89-103.  https://doi.org/10.5114/pg.2018.81072
  5. Siegel RL, Miller KD, Goding SA, Fedewa SA, Butterly LF, Anderson CJ, Cercek A. Colorectal cancer statistics, 2020. CA: a cancer journal for Clinicians. 2020;70(3):145-164.  https://doi.org/10.3322/caac.21601
  6. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J. Clin. 2011;61(2):69-90.  https://doi.org/10.3322/caac.20107
  7. American Cancer Society. Cancer facts and figures 2014. Atlanta: American Cancer Society. 2014;68. 
  8. Shelygin YuA. Colon cancer. Handbook of Coloproctology. Ed. Shelygin Yu.A., Blagorodniy L.A. M.: Litterra; 2014. (In Russ.).
  9. Kaprin AD, Starinskiy VV, Petrova GV. The state of cancer care for the population of Russia in 2014. M.: Moscow Research Institute PA Herzen; 2015. (In Russ.).
  10. Yang X-F, Pan K. Diagnosis and management of acute complications in patients with colon cancer: bleeding, obstruction, and perforation. Chines Journal of Cancer Research. 2014;26(3):331-340.  https://doi.org/10.3978/j.issn.1000-9604.2014.06.11
  11. Pak H, Maghsoud LH, Soltanian A, Gholami F. Surgical complications in colorectal cancer patients. Annals of Medicine and Surgery. 2020;55:13-18.  https://doi.org/10.1016/j.amsu.2020.04.024
  12. Aliev VA, Barsukov YuA, Nikolaev AV. Colorectal cancer with synchronous metastases: rationale for cytoreductive surgers and outlooks — surgeon’s view. Oncological proctology. 2012;4:15-21. (In Russ.).
  13. Mahnken AH, Pereira PL, de Baere T. Interventional Oncologic Approaches to liver metastases. Radiology. 2013;266(2):407-430.  https://doi.org/10.1148/radiol.12112544
  14. Ejaz A, Semenov E, Spolverato G, Kim Y, Tanner D, Hundt J, Rawlik TM. Synchronous primary colorectal and liver metastasis: impact of operative approach on clinical outcomes and hospital charges. HPB (Oxford). 2014;16(12):1117-1126. https://doi.org/10.1111/hpb.12302
  15. Kelly ME, Spolverato G, Le GN, Mavros MN, Doyle F, Pawlik TM, Winter DS. Synchronous colorectal liver metastasis: a network meta-analysis review comparing classical, combined, and liver-first surgical strategies. Journal of Surgical Oncology. 2015;111(3):341-351.  https://doi.org/10.1002/jso.23819
  16. Maistrenko NA, Khvatov AA, Sazonov AA. Postoperative complications of combined surgeries in patients with disseminated forms of colon cancer. Grekov’s Bulletin of Surgery. 2017;176(2):86-94. (In Russ.). https://doi.org/10.24884/0042-4625-2017-176-2-86-94
  17. Zarour LR, Anand S, Billingsley KG, Bisson WH, Cercek A, Clarke MF, Coussens LM, Gast CE, Geltzeirler CB, Hansen L et al. Colorectal liver metastases: evoling paradigms and future directions. Cell Mol Gastroenterol. Hepatol. 2017;3(2):163-173. 
  18. de Long MC, Beckers RCJ, van Woerden V, Sijmons JML, Bemelmans MHA, van Dam RM, Dejong CHC. The liver-first approach in patients with colorectal cancer and synchronous colorectal liver metastases. HPB (Oxford). 2018;2-(7):631-640.  https://doi.org/10.1016/j.hpb.2018.01.005
  19. Engstrand J, Nilson H, Stromberg C, Jonas E, Freedman J. Colorectal cancer liver metastases — a population-based study on incidence, management and survival. BMC Cancer. 2018;18(1):78.  https://doi.org/10.1186/s12885-017-3925-x
  20. Venkat ShR, Mohan PP, Gandhi RT. Colorectal liver metastasis: overview of treatment paradigm highlighting the role ablation. Vascular and interventional radiology. 2018;210(4):883-890.  https://doi.org/10.2214/AJR.17.18574
  21. Chow FC-L, Chok KS-H. Colorectal liver metastases: An update on multidisciplinary approach. World J Hepatol. 2019;11(2):150-172.  https://doi.org/10.4254/wjh.v11.i2.150
  22. Ferrand F, Malka D, Bourredjem A, Allonier C, I Bouche O, Louafi S, Boige V, Mousseau M, Raoul JL, Bedenne L, Leduc B, Deguiral P, Faron M, Pignon JP, Ducreux M. Impact of primary tumor resection on survival of patients with colorectal cancer and synchronous metastases treated by chemotherapy. Eur J Cancer. 2013;49(1):90-77.  https://doi.org/10.1016/j.ejca.2012.07.006
  23. Kurpeshev OK, Osinsky SP, Florovskaya NYu, Silantyeva IK, Lebedeva TV. Lifespan of patients with metastatic colorectal cancer in the liver after incomplete courses of chemotherapy or symptomatic treatment. Oncology. 2013;15(4):301-306. (In Russ.).
  24. Folprecht G, Gruenberger T, Bechstein W, Suedhoff T, Rentsch A, Köhne C-H. Survival of patients colorectal liver metastases treated with FOLFOX/cetuximab or multidisciplinary concept (CELM study). Annals of Oncology. 2014;25(5):1018-1025. https://doi.org/10.1093/annonc/mdu088
  25. Imai K, Adam R, Biaba H. How to increase the resectability of initially uncresectable colorectal liver metastases: a surgical perspective. Annals od Gastroenterological Surgery. 2019;3(5):476-486.  https://doi.org/10.1002/ags3.12276
  26. Lemke J, Cammerer G, Ganser J, Scheele J, Xu P, Sander S, Henne-Bruns D, Kornmann M. Survival and prognostic factors of colorectal liver metastases after surgical and nonsurgical treatment. Clin Colorectal cancer. 2016;15(4):183-192.  https://doi.org/10.1016/j.clcc.2016.04.007
  27. Adam R, de Gramont A, Figueras J, Kukodo N, Kinstlinger F, Loyer E, Poston G, Roigier Ph, Rubbia-Brand L, Sobrero A, et al. Managing synchronous liver metastases form colorectal cancer: a multidisciplinary international consensus. Cancer treatment Reviews. 2015;41(9):729-741.  https://doi.org/10.1016/j.ctrv.2015.06.006
  28. Kemeny NE, Chou JF, Boucher TM, Capanu M, De Matteo PP, Jarnagin WP, Allen PJ, Fong YC, Cercek A, D’Angelica MI. Updated long-term survival for patient with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion an systemic chemotherapy. J Surg Oncol. 2016;113(5):477-484.  https://doi.org/10.1002/jso.24189
  29. Wanis KN, Pineda-Solis K, Tun-Abraham ME, Yeoman J, Welch S, Vogt K, van Koughnett JAM, OttM, Hernandez-Alejandro R. Management of colorectal cancer with synchronous liver metastases: impact of multidisciplinary case conference review. Hepatobiliary Surg Nutr. 2017;6(3):162-169.  https://doi.org/10.21037/hbsn.2017.01.01
  30. Qadan M, D’Angelica MI. Extending the limits of resection for colorectal liver metastases: positive resection margin and outcome after resection of colorectal cancer liver metastases. J Gastrointest Surg. 2017; 21(1):196-198.  https://doi.org/10.1007/s11605-016-3253-5
  31. Vallance AE, van der Mellen J, Kuruba A, Charman SC, Botterill ID, Prasad KR, Hill J, Jayne DG. Walker K. The liming of liver resection in patients with colorectal cancer and synchronous liver metastases: a population-based study of current practice and survival. Colorectal Disease. 2018;20(16):486-495.  https://doi.org/10.1111/codi.14019
  32. Cetin B, Bilgetekin I, Cengiz M, Oset A. Managing synchronous liver metastases in colorectal cancer. Indian Journal of Surgical Oncology. 2018;9(14);461-471.  https://doi.org/10.1007/s13193-018-0765-3
  33. Muangkaew P, Cho JY, Han HS, Yoon-YS, Choi Y, Jang JY, Cho H, Jang JS, Kwon SU. Outcomes of simultaneous major liver resection and colorectal surgery for colorectal liver metastases. Journal of Gastrointestinal Surgery. 2016;20(3):554-563. 
  34. Silberhumer GR, Paty PB, Denton B, Guillem J, Gonen M, Araujo RLC, Nash GM, Temple LK, Allen P, De Matteo RP, Weiser MR, Wong WD et al. Long-term oncologic outcomes for simultaneous resection of synchronous metastatic liver and primary colorectal cancer. Surgery. 2016;160(1):554-563.  https://doi.org/10.1016/j.surg.2016.02.029
  35. Fukami Y, Kaneoka Y, Maeda A, Takayama Y, Onoe Sh, Isogai M. Simultaneous resection for colorectal cancer and synchronous liver metastases. Surg. Today. 2016;46(2):176-182.  https://doi.org/10.1007/s00595-015-1188-1
  36. Ponomarenko AA, Achkasov SI, Panina MV, Rybakov EG. Simultaneous resections for synchronous colorectal cancer liver metastases. Koloproctologiya. 2017;4:45-53. (In Russ.).
  37. Gavrilidis P, Sutcliffe RP, Hodson J, Marudanayagam R, Isaac J, Azonlay D, Roberts KJ. Simultaneous versus delayed hepatectomy for synchronous colorectal liver metastases: a systemic review and meta-analysis. HPB (Oxford). 2018;20(1):11-19.  https://doi.org/10.1016/j.hpb.2017.08.008
  38. Zhang XL, Liu RF, Zhang D, Zhang YS, Wang T. Laparoscopic versus open liver resection for colorectal liver metastases: a systematic review and meta-analysis of studies with propensity score-based analysis. Int J Surg. 2017;44:191-203.  https://doi.org/10.1016/j.ijsu.2017.05.073
  39. Fretland AA, Dagenborg VJ, Bjornelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW, Hausken J, Tonnessen TI, Abildgaard A, Barkhatov L et al. Laparoscopic versus open resection for colorectal liver metastases: The OSLO-COMET randomized controlled trial. Ann Surg. 2018;267(2):199-207.  https://doi.org/10.1097/SLA.0000000000002353
  40. Torchua NR, Ponomarenko AA, Rybakov EG, Achkasov SI. Laparoscopic liver resection in surgery for colorectal cancer metastases. Coloproctologiya. 2019;18(1(67)):58-65. (In Russ.). https://doi.org/10.33878/2073-7556-2019-18-1-58-65
  41. Stilwell AP, Buettner PG, Ho YH. Meta-analysis of survival of patients with stage IV colorectal cancer managed with surgical resection versus chemotherapy alone. World J Surg. 2010;34(4):794-807.  https://doi.org/10.1007/s00268-009-0366-y
  42. Abdulaev MA, Napol’skaya EV, Tsikoridze MYu. Minimally invasive methods of local treatment of colorectal cancer liver metastases: state of the art (a review of literature). Pelvic Surgery and Oncology. 2016;6(1):43-47. (In Russ.). https://doi.org/10.17650/2220-3478-2016-6-1-43-47
  43. Kozlov SV, Kaganov OI, Tkachev MV, Kozlov AM, Shvets DS. Radiofrequency thermal ablation of the combined treatment of patients with liver bilobar metastases. PA Herzen Journal of Oncology/Zhurnal im. PA Gertsena. 2014;3(3):11-17. (In Russ.).
  44. Ko S, Jo H, Park E, Kim S, Seo HI. Comparative analysis of radiofregnency ablation and resection for resectable colorectal liver metastases. World J Gastroenterol. 2014;20(2):525-531.  https://doi.org/10.3748/wjg.v20.i2.525
  45. Shady W, Petre EN, Gonen M, Erinjeri JP, Brown KT, Covey AM, Alago W, Durack JC, Maybody M, Brody A, Stegelbaum RH, et al. Percitaneous radiofregency ablation of colorectal cancer liver metastases: factors affecting outcomes- A1-year experience at a single center. Radiology. 2016;278(2):601-611.  https://doi.org/10.1148/radiol.2015142489
  46. Cherkasov MF, Dmitriev AV, Groshilin VS, Pomazkov AA, Startsev YuM, Melikova SG. Experience of surgical treatment of colorectal cancer with liver metastases. Coloproctologiya. 2017;2(60):62-67. (In Russ.). https://doi.org/10.33878/2073-7556-2017-0-2-62-67
  47. van Amerongen MJ, Jenniskens SFM, van den Boezem PB, Fütterer JJ, de Wilt JHW. Radiofrequency ablation compared to surgical resection for curative treatment of patients with colorectal liver metastases — a meta-analysis. HPB (Oxford). 2017;19(9):749-756.  https://doi.org/10.1016/j.hpb.2017.05.011
  48. Zarivchatskiy MF, Mugatarov IN, Kaminskikh ED, Blinov SA, Denisov SA, Kravtsova TYu. Surgical treatment of colorectal cancer liver metastases. Annaly chirurgicheskoy gepatologii = Annals of HPB Surgery. 2018;23(1):80-87. (In Russ.). https://doi.org/10.16931/1995-5464.2018-1-80-87
  49. Ionkin DA, Zhavoronkova OI, Stepanova YuA, Gavrilov YaYa, Vishnevsky VA, Zhao AV. Thermal methods of local destruction (RFA, cryodestruction, MVA) in metastatic colorectal liver cancer. Postgraduate Bulletin of the Volga Region. 2018;18(5-6):127-145. (In Russ.).
  50. Song P, Sheng L, Sun Y, An Y, Guo Y, Zhang Y. The clinical utility and outcomes of microwave ablation for colorectal cancer liver metastases. Oncotarget. 2017;8(31):51792-51799. https://doi.org/10.18632/oncotarget.15244
  51. Zhou F, Yu X, Liang P, Han Z, Cheng Z, Yu J, Liu F, Hu Y. Does primary tumor location impact the prognosis of colorectal liver metastases patients after microwave ablation? — Lessons from 10 years experience. Oncotarget. 2017;8(59):100791-100800. https://doi.org/10.18632/oncotarget.18764
  52. Shady W, Petre EH, Do KG, Gonen M, Yarmohammadi H, Brown KT, Kemeny NE, D’Angelica M, Kihgham PT, Solomon SB, Sofocleous CT. Percutaneous microwave versus radiofrequency ablation of colorectal liver metastases: ablation with clear margins (Ao) provides the best local tumor control. J Vasc Interv Radiol. 2018;29(2):268-275.  https://doi.org/10.1016/j.jvir.2017.08.021
  53. Li Zh, Fu Y, Li Q, Yan F, Zhao J, Dong X, Zhang Y. Cryoablation plus chemotherapy in colorectal cancer patients with liver metastases. Tumour Biol. 2014;35(11):10841-10848. https://doi.org/10.1007/s13277-014-2374-2
  54. Ihnat P, Skacelikova E, Penka I, Tesar M. Stereotactic body radiotherapy using the «Cyber Knife» system in the treatment of patients with liver metastases: state of the art. OncoTarget and Therapy. 2018;11:4685-4691. https://doi.org/10.2147/OTT.S165878
  55. Mahadevan A, Blanck O, Lanciano R, Reddada A. Stereotactic body radiotherapy (SBPT) for liver metastases — clinical outcomes from the international multiinstitutional RSSearch patients registry. Radiotion Oncology. 2018;13(26):2-11.  https://doi.org/10.1186/s13014-018-0969-2
  56. Mendez RA, Keskin-Cambay F, van Os RM, Nuyttens JJ, Heijmen BJM, Uzermans JNM, Verhoef C. Institutional experience in the treatment of colorectal liver metastases with stereotactic body radiation therapy. Rep Pract Oncol Radiother. 2017;22:126-131.  https://doi.org/10.1016/j.rpor.2016.10.003
  57. Yuan Z-Y, Meng MB, Liu CL, Wang HH, Jiang Ch, Song YCh, Zhuang H-Q, Yang D, Wang J-Sh, Wei W, Li F-T, Zhao L-J, Wang P. Stereotactic body radiation therapy using the Cyber Knife system for patients with liver metastases. OncoTargets Ther. 2014;7:915-923.  https://doi.org/10.2147/OTT.S58409
  58. Chapelli N, Matysiak-Budnik T, Donane F, Metaire S, Rougier P, Touchefeu Y. Hepatic arterial infusion in the management of colorectal cancer liver metastasis: current and future perspective. Dig liver Dis. 2018;50(3):220-225.  https://doi.org/10.1016/j.dld.2017.12.004
  59. Vigano L, Darwich SS, Rimassa L, Cimino M, Carnaghi C, Donadon M, Procopio F, Personeni N, Del Fabbo D, Santoro A, Torzilli G. Progression of colorectal liver metastases from the end of chemotherapy to resection: a new contraindication to surgery? Annals of Surgical Oncology. 2018;25(6):1676-1685. https://doi.org/10.1245/s10434-018-6387-8
  60. Al-Sharif E, Simoneau E, Hassanin M. Portal vein embolization effect on colorectal cancer liver metastasis progression: lessons learned. World J Clin Oncol. 2015;6(5):142-146.  https://doi.org/10.5306/wjco.V6.i5.142
  61. Massman A, Rodt T, Marquardt S, Seidel R, Thomas K, Wacker F, Richter GM, Kanczor HU, Bücker A, Pereira PL, Sommer CM. Transarterial chemoembolization (TACE) for colorectal liver metastases — current status and critical review. Langenbecks Arch Surg. 2015;400(6):641-659.  https://doi.org/10.1007/s00423-015-1308-9
  62. Shady W, Kishore S, Gavane S, Do RK, Osborne JR, Ulaner GA, Gonen M, Ziv E, Boas FE, Sofocleous CT. Metabolic tumor volume and total lesion glucolysis on FDG-PET/CT can predict overall survival after (90) Y radioembolization of colorectal liver metastases: a comparison with SUVmax, SUVpeak and RESIST 1.0. Eur J Radiol. 2016;85(6):1224-1231. https://doi.org/10.1016/j.ejrad. 2016.03.029
  63. Cui CH, Huang SX, Qi J, Zhu HJ, Huang ZH, Yu JL. Neoadjuvant chemotherapy (NCT) plus targeted agents versus NCT alone in colorectal liver metastases patients: a systemic review and meta-analysis. Onco Target. 2015;6(41):44005-44018. https://doi.org/10.18632/oncotarget.5875
  64. Vladimirova LYu, Abramova NA, Storozhokova AE. Targeted therapy with anti-EGFR monoclonal antibodies in the treatment of colorectal cancer. Malignant tumors. 2016;(4s1):87-91. (In Russ.).
  65. Sabanathan D, Eslick GD, Shannon J. Use of neoadjuvant chemotherapy plus molecular targeted therapy in colorectal liver metastases: a systematic review and meta-analysis. Clin Colorectal Cancer. 2016; 15(4):141-147.  https://doi.org/10.1016/j.clcc.2016.03.007
  66. Starzl TE, Fung JJ. Themes of liver transplantation. Hepatology. 2010; 51(6):1869-1884. https://doi.org/10.1002/hep.23595
  67. Hagness M, Foss A, Line PD, Scholtz T, Jorgensen PF, Fosby B, Boberg KM, Mathisen O, Gladhaug IP, Egge TS, Solberg S, Hausken J, Dueland S. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann. Surg. 2013;257(5):800-806.  https://doi.org/10.1097/SLA.0b013e3182823957
  68. Hrehoret D, Alexadrescu S, Braşoveanu V, Grigorie R, Zelinski C, Popescu I. Liver transplantation in a patient with unresectable colorectal liver metastases — a case report. Chirurgia (Bucur). 2013;108(5):719-724. PMID: 24157119.
  69. Hagness M, Foss A, Egge TS, Dueland S. Patterns of recurrence after liver transplantation for nonresectable liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg Oncol. 2014;21(4):1323-1329. https://doi.org/10.1245/s10434-013-3449-9
  70. Line PD, Hagness M, Berstad AE, Foss A, Dueland S. A novel concept for partial liver transplantation in nonresectable colorectal liver metastases: The RAPID concept. Ann Surg. 2015;262(1):5-9.  https://doi.org/10.1097/SLA.0000000000001165
  71. Caicedo LA, Buitrago D, Thomas LS, Villegas JI, Duque M, Serrano O, Arrunategui AM, Restrepo JG, Echeverri GJ. Liver transplantation for unresectable metastases from colon adenocarcinoma. Case Reports in Gastroenterology. 2016;10(3):808-813.  https://doi.org/10.1159/000454984
  72. Toso C, Pinto MH, Abdres A, Castro-Sonsa F, Adam R, Kalil A, Clavien PA, Furtado E, Barroso E, Bismuth H. Compagnosis hepatobiliaires group. Liver transplantation for colorectal liver metastatic: survival without recurrence can be achieved. Liver Transpl. 2017;23(8):1073-1076. https://doi.org/10.1002/lt.24791
  73. Herrero A, Madalin S, Panaro F. Liver transplantation for irresectable colorectal liver metastases: still a contraindication? Heparobiliary Surg Nutr. 2018;7(6):475-478.  https://doi.org/10.21037/hbsn.2018.08.04
  74. Königsrainer A, Templin S, Capobianco I, Königsrainer I, Bitzer M, Zender L, Sipos L, Kanz L, Wagner S, Nadalin S. Paradigm shift in the management of irresectable colorectal liver metastases: living donor auxiliary partial orthotopic liver transplantation in combination with two-stage hepatectomy (LD-RAPID). Ann Surg. 2019;270:327-332.  https://doi.org/10.1097/SLA.0000000000002861
  75. Simoneau E, D Angelica M, Halazun KJ. Liver transplantation for colorectal liver metastasis. Curr Opin Organ Transplant. 2019;24(2):175-181.  https://doi.org/10.1097/SLA.0000000000000623
  76. Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bjornbeth BA, Hagness M, Line P-D. Survival following liver transplantation for patients wits nonresectable liver-only colorectal metastases. Ann Surg. 2020;271(2):212-218.  https://doi.org/10.1097/SLA.0000000000003404
  77. Gorgen A, Ivanics T, Sapisochin G. Liver transplantation for unresectable colorectal metastasis: a new hope. Hepatobiliary Surg Nutr. 2020;9(5):665-668.  https://doi.org/10.21037/hbsn.2020.01.04
  78. Lanari J, Dueland S, Line P-D. Liver transplantation for colorectal liver metastasis. Current Transplantation Reports. 2020;7:311-316.  https://doi.org/10.1007/s40472-020-00298-8
  79. Line P-D, Ruffolo LI, Toso C, Dueland S, Nadalin S, Hernandez-Alejandro R. Liver transplantation for colorectal liver metastases: What do we need to know? Int J Surg. 2020;82:87-92.  https://doi.org/10.1016/j.ijsu.2020.03.079
  80. Smedman TM, Line PD, Hagness M, Syversveen T, Grut H, Dueland S. Liver transplantation for unresectable colorectal liver metastases in patients and donors with extended criteria (SECA‐II arm D study). BJS Open. 2020;4(3):467-477.  https://doi.org/10.1002/bjs5.50278
  81. Choi JU, Hwang S, Jung DH, Park GC, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Lee SG. Living donor liver transplantation for unresectable colorectal liver metastasis: Report of a case with 13-year follow-up without recurrence. Ann hepatobiliary Pancreat Surg. 2020;24(2); 188-191.  https://doi.org/10.14701/ahbps.2020.24.2.188
  82. Puia-Negulescu S, Lebbose F, Mabrut JY, Muller X, Rossignol G, Antonini T, Erard D, Radenne S, Guillet M, Souquet JC, Mohkam K, Lesurtel M. Liver transplantation for colorectal liver metastases: current management and future perspectives. Int J Moi Sci. 2021;22(6):3093. https://doi.org/10.3390/ijms22063093
  83. Sapisochin G. University Health Network, Toronto. Assessment of a protocol using a combination of neo-adjuvant chemotherapy plus living donor liver transplantation for non-resectable liver metastases from colorectal cancer. https://clinicaltrials. gov/ct2/show/NCT 02864485
  84. Porshennikov IA, Sokolov AV, Shchekina EE, Chubukov AYu, Tretyakova TA, Ostanina AB, Kartashov AS, Korobeynikova MA, Yushina EG, Bykov AYu. Liver transplantation for metastatic colorectal cancer (case report). Annals of Surgical Hepatology. 2018;23(4):54-67. (In Russ.). https://doi.org/10.16931/1995-5464.2018454-67
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