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Porembskaya O.Ya.

Mechnikov North-Western State Medical University;
Institute of Experimental Medicine

Kravchuk V.N.

Mechnikov North-Western State Medical University;
Kirov Military Medical Academy

Lobastov K.V.

Pirogov Russian National Research Medical University

Kuzmina-Krutetskaya S.R.

Mechnikov North-Western State Medical University

Laberko L.A.

Pirogov Russian National Research Medical University

Chesnokov M.Sh.

Mechnikov North-Western State Medical University

Velikanova K.E.

Mechnikov North-Western State Medical University

Saiganov S.A.

Mechnikov North-Western State Medical University

Pulmonary artery thrombosis: strategy of anticoagulation

Authors:

Porembskaya O.Ya., Kravchuk V.N., Lobastov K.V., Kuzmina-Krutetskaya S.R., Laberko L.A., Chesnokov M.Sh., Velikanova K.E., Saiganov S.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2021;(11): 76‑82

DOI: 10.17116/hirurgia202111176

Read: 3202 times

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Table of contents

PULMONARY ARTERY THROMBOSIS: STRATEGY OF ANTICOAGULATION
PULMONARY ARTERY THROMBOSIS: STRATEGY OF ANTICOAGULATION

To cite this article:

Porembskaya OYa, Kravchuk VN, Lobastov KV, et al. . Pulmonary artery thrombosis: strategy of anticoagulation. Pirogov Russian Journal of Surgery. 2021;(11):76‑82. (In Russ.)
https://doi.org/10.17116/hirurgia202111176

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
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Abstract:

This review is devoted to the management of primary artery thrombosis (PAT). This disease was always considered only as a part of other venous thromboembolic events, in particular isolated pulmonary embolism (PE). Various studies show that PAT can develop as an independent event without concomitant damage to extra-vessels. PAT is characterized by own typical signs as primary and recurrent event that can determine special strategies of treatment. However, there are no studies devoted to this problem. We can only make some assumptions about PAT anticoagulation (AC) considering data on isolated PE comprising PAT. These data are available in PADIS-PE, ASPIRE, EINSTEIN-PE, Hokusai-VTE studies underlying modern guidelines of various societies. In the absence of studies on PAT AC these guidelines should regulate PAT AC approaches. AC is recommended in all cases of PE except isolated subsegmental PAT in ambulatory patients. Duration of AC depends on risk factors (major or minor). Anticoagulation for PAT following chronic inflammatory diseases is still disputable.

Keywords:

pulmonary artery thrombosis
pulmonary embolism
anticoagulation
direct oral anticoagulants

Authors:

Porembskaya O.Ya.

Mechnikov North-Western State Medical University;
Institute of Experimental Medicine

Kravchuk V.N.

Mechnikov North-Western State Medical University;
Kirov Military Medical Academy

Lobastov K.V.

Pirogov Russian National Research Medical University

Kuzmina-Krutetskaya S.R.

Mechnikov North-Western State Medical University

Laberko L.A.

Pirogov Russian National Research Medical University

Chesnokov M.Sh.

Mechnikov North-Western State Medical University

Velikanova K.E.

Mechnikov North-Western State Medical University

Saiganov S.A.

Mechnikov North-Western State Medical University

Received:

28.12.2020

Accepted:

02.03.2021

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References:

  1. Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI; ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol. 2014;34(11):2363-2371. https://doi.org/10.1161/ATVBAHA.114.304488
  2. Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis [Internet]. Springer New York LLC; 2016 Jan 1 [cited 2020 Dec 20];41(1):3-14.  https://doi.org/10.1007/s11239-015-1311-6
  3. Porembskaya O, Toropova Y, Tomson V, Lobastov K, Laberko L, Kravchuk V, Saiganov S, Brill A. Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence. Int J Mol Sci. 2020;21(14):5086. https://doi.org/10.3390/ijms21145086
  4. van Langevelde K, Šrámek A, Vincken PWJ, van Rooden JK, Rosendaal FR, Cannegieter SC. Finding the origin of pulmonary emboli with a total-body magnetic resonance direct thrombus imaging technique. Haematologica [Internet]. Ferrata Storti Foundation; 2013 Feb 1 [cited 2020 Feb 26];98(2):309-315.  https://doi.org/10.3324/haematol.2012.069195
  5. Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ní Áinle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41(4):543-603.  https://doi.org/10.1093/eurheartj/ehz405
  6. Gunen H, Gulbas G, In E, Yetkin O, Hacievliyagil SS. Venous thromboemboli and exacerbations of COPD. Eur Respir J. 2010;35(6):1243-1248. https://doi.org/10.1183/09031936.00120909
  7. Erelel M, Cuhadaro GC, Ece T, Arseven O. The frequency of deep venous thrombosis and pulmonary embolus in acute exacerbation of chronic obstructive pulmonary disease. Respir Med. 2002;96(7):515-518.  https://doi.org/10.1053/rmed.2002.1313
  8. Lundy JB, Oh JS, Chung KK, Ritter JL, Gibb I, Nordmann GR, Sonka BJ, Tai NR, Aden JK, Rasmussen TE. Frequency and relevance of acute peritraumatic pulmonary thrombus diagnosed by computed tomographic imaging in combat casualties. J Trauma Acute Care Surg. 2013;75:S215-220.  https://doi.org/10.1097/TA.0b013e318299da66
  9. Alatri A, Schoepfer A, Fournier N, Engelberger RP, Safroneeva E, Vavricka S, Biedermann L, Calanca L, Mazzolai L; Swiss IBD Cohort Study Group. Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort. Scand J Gastroenterol. 2016;51(10):1200-1205. https://doi.org/10.1080/00365521.2016.1185464
  10. Porembskaya O, Lobastov K, Pashovkina O, Tsaplin S, Schastlivtsev I, Zhuravlev S, Laberko L, Rodoman G, Kravchuk V, Skvortsov A, Saiganov S. Thrombosis of pulmonary vasculature despite anticoagulation and thrombolysis: The findings from seven autopsies. Thromb Updat. Elsevier BV. 2020;1:100017. https://doi.org/10.1016/j.tru.2020.100017
  11. Ribeiro DD, Lijfering WM, Van Hylckama Vlieg A, Rosendaal FR, Cannegieter SC. Pneumonia and risk of venous thrombosis: results from the MEGA study. J Thromb Haemost. 2012;10(6):1179-1182. https://doi.org/10.1111/j.1538-7836.2012.04732.x
  12. Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, Jeanpierre E, Rauch A, Labreuche J, Susen S; Lille ICU Haemostasis COVID-19 Group. Pulmonary Embolism in Patients With COVID-19: Awareness of an Increased Prevalence. Circulation. 2020;142(2):184-186.  https://doi.org/10.1161/CIRCULATIONAHA.120.047430
  13. Van Stralen KJ, Doggen CJ, Bezemer ID, Pomp ER, Lisman T, Rosendaal FR. Mechanisms of the factor V Leiden paradox. Arterioscler Thromb Vasc Biol. 2008;28(10):1872-1877. https://doi.org/10.1161/ATVBAHA.108.169524
  14. Wiener RS, Schwartz LM, Woloshin S. Time trends in pulmonary embolism in the United States: evidence of overdiagnosis. Arch Intern Med. 2011;171(9):831-837.  https://doi.org/10.1001/archinternmed.2011.178
  15. Carrier M, Righini M, Wells PS, Perrier A, Anderson DR, Rodger MA, Pleasance S, Le Gal G. Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies. J Thromb Haemost. 2010;8(8):1716-1722. https://doi.org/10.1111/j.1538-7836.2010.03938.x
  16. Anderson DR, Kahn SR, Rodger MA, Kovacs MJ, Morris T, Hirsch A, Lang E, Stiell I, Kovacs G, Dreyer J, Dennie C, Cartier Y, Barnes D, Burton E, Pleasance S, Skedgel C, O’Rouke K, Wells PS. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA. 298(23):2743-2753. https://doi.org/10.1001/jama.298.23.2743
  17. Eyer BA, Goodman LR, Washington L. Clinicians’ response to radiologists’ reports of isolated subsegmental pulmonary embolism or inconclusive interpretation of pulmonary embolism using MDCT. AJR Am J Roentgenol. 2005;184(2):623-628.  https://doi.org/10.2214/ajr.184.2.01840623
  18. Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, Huisman M, King CS, Morris TA, Sood N, Stevens SM, Vintch JRE, Wells P, Woller SC, Moores L. Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report. Chest. 2016;149(2):315-352.  https://doi.org/10.1016/j.chest.2015.11.026
  19. Konstantinides S, Meyer G. Management of acute pulmonary embolism 2019: what is new in the updated European guidelines? Intern Emerg Med. 2020;15(6):957-966.  https://doi.org/10.1007/s11739-020-02340-0
  20. Khan F, Rahman A, Carrier M, Kearon C, Weitz JI, Schulman S, Couturaud F, Eichinger S, Kyrle PA, Becattini C, Agnelli G, Brighton TA, Lensing AWA, Prins MH, Sabri E, Hutton B, Pinede L, Cushman M, Palareti G, Wells GA, Prandoni P, Büller HR, Rodger MA; MARVELOUS Collaborators. Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis. BMJ. 2019;366:14363. https://doi.org/10.1136/bmj.l4363
  21. Couturaud F, Sanchez O, Pernod G, Mismetti P, Jego P, Duhamel E, Provost K, dit Sollier CB, Presles E, Castellant P, Parent F, Salaun PY, Bressollette L, Nonent M, Lorillon P, Girard P, Lacut K, Guégan M, Bosson JL, Laporte S, Leroyer C, Décousus H, Meyer G, Mottier D; PADIS-PE Investigators. Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial. JAMA. 2015;314(1):31-40.  https://doi.org/10.1001/jama.2015.7046
  22. Bertoletti L, Quenet S, Laporte S, Sahuquillo JC, Conget F, Pedrajas JM, Martin M, Casado I, Riera-Mestre A, Monreal M; RIETE Investigators. Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry. Respir Res. 2013;14(1):75.  https://doi.org/10.1186/1465-9921-14-75
  23. Kearon C, Gent M, Hirsh J, Weitz J, Kovacs MJ, Anderson DR, Turpie AG, Green D, Ginsberg JS, Wells P, MacKinnon B, Julian JA. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med. 1999;340(12):901-907.  https://doi.org/10.1056/NEJM199903253401201
  24. Agnelli G, Prandoni P, Becattini C, Silingardi M, Taliani MR, Miccio M, Imberti D, Poggio R, Ageno W, Pogliani E, Porro F, Zonzin P; Warfarin Optimal Duration Italian Trial Investigators. Extended oral anticoagulant therapy after a first episode of pulmonary embolism. Ann Intern Med. 2003;139(1):19-25.  https://doi.org/10.7326/0003-4819-139-1-200307010-00008
  25. Becattini C, Agnelli G, Schenone A, Eichinger S, Bucherini E, Silingardi M, Bianchi M, Moia M, Ageno W, Vandelli MR, Grandone E, Prandoni P; WARFASA Investigators. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med. 2012;366(21):1959-1967. https://doi.org/10.1056/NEJMoa1114238
  26. Brighton TA, Eikelboom JW, Mann K, Mister R, Gallus A, Ockelford P, Gibbs H, Hague W, Xavier D, Diaz R, Kirby A, Simes J; ASPIRE Investigators. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med. 2012;367(21):1979-1987. https://doi.org/10.1056/NEJMoa1210384
  27. Simes J, Becattini C, Agnelli G, Eikelboom JW, Kirby AC, Mister R, Prandoni P, Brighton TA; INSPIRE Study Investigators (International Collaboration of Aspirin Trials for Recurrent Venous Thromboembolism). Aspirin for the prevention of recurrent venous thromboembolism: the INSPIRE collaboration. Circulation. 2014;130(13):1062-1071. https://doi.org/10.1161/CIRCULATIONAHA.114.008828
  28. Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; EINSTEIN CHOICE Investigators. Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017;376(13):1211-1222. https://doi.org/10.1056/NEJMoa1700518
  29. Büller HR, Prins MH, Lensin AW, Decousus H, Jacobson BF, Minar E, Chlumsky J, Verhamme P, Wells P, Agnelli G, Cohen A, Berkowitz SD, Bounameaux H, Davidson BL, Misselwitz F, Gallus AS, Raskob GE, Schellong S, Segers A, EINSTEIN—PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med. 2012;366(14):1287-1297. https://doi.org/10.1056/NEJMoa1113572
  30. Bauersachs R, Berkowitz SD, Brenner B, Buller HR, Decousus H, Gallus AS, Lensing AW, Misselwitz F, Prins MH, Raskob GE, Segers A, Verhamme P, Wells P, Agnelli G, Bounameaux H, Cohen A, Davidson BL, Piovella F, Schellong S, EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363(26):2499-2510. https://doi.org/10.1056/NEJMoa1007903
  31. Schulman S, Kearon C, Kakkar AK, Schellong S, Eriksson H, Baanstra D, Kvamme AM, Friedman J, Mismetti P, Goldhaber SZ; RE-MEDY Trial Investigators; RE-SONATE Trial Investigators. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med. 2013;368(8):709-718.  https://doi.org/10.1056/NEJMoa1113697
  32. Büller HR, Décousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P, Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369(15):1406-1415. https://doi.org/10.1056/NEJMoa1306638
  33. Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, Hutten BA, Jaff MR, Manja V, Schulman S, Thurston C, Vedantham S, Verhamme P, Witt DM, D Florez I, Izcovich A, Nieuwlaat R, Ross S, J Schünemann H, Wiercioch W, Zhang Y, Zhang Y. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv. 2020;4(19):4693-4738. https://doi.org/10.1182/bloodadvances.2020001830
  34. Kearon C, Ageno W, Cannegieter SC, Cosmi B, Geersing GJ, Kyrle PA; Subcommittees on Control of Anticoagulation, and Predictive and Diagnostic Variables in Thrombotic Disease. Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH. J Thromb Haemost. 2016;14(7):1480-1483. https://doi.org/10.1111/jth.13336
  35. Bernstein CN, Blanchard JF, Houston DS, Wajda A. The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a population-based cohort study. Thromb Haemost. 2001;85(3):430-434. 
  36. Tajdini M, Hosseini SM. From Pulmonary Embolism to Inflammatory Bowel Disease; Give Tunnel Vision up. Emerg (Tehran). 2016;4(1):41-44. 
  37. Nguyen GC, Bernstein CN, Bitton A, Chan AK, Griffiths AM, Leontiadis GI, Geerts W, Bressler B, Butzner JD, Carrier M, Chande N, Marshall JK, Williams C, Kearon C. Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology. Gastroenterology. 2014;146(3):835-848.e6.  https://doi.org/10.1053/j.gastro.2014.01.042
  38. Albishi AM, Chakik R, Alshamrani AS. Recurrent Unprovoked Venous Thrombosis (Cerebral Sinus Thrombosis and Mesenteric Vein Thrombosis) in Young Patient with Crohn’s Disease: A Case Report and Review. Case Rep Gastrointest Med. 2020;2020:8863900. https://doi.org/10.1155/2020/8863900
  39. Aleva FE, Voets LWLM, Simons SO, de Mast Q, van der Ven AJAM, Heijdra YF. Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD: A Systematic Review and Meta-analysis. Chest. 2017;151(3):544-554.  https://doi.org/10.1016/j.chest.2016.07.034
  40. Le Mao R, Tromeur C, Bazire A, Gouillou M, Guegan M, Lacut K, Delluc A, Mottier D, Leroyer C, Couturaud F. Risk of recurrent venous thromboembolism in COPD patients: results from a prospective cohort study. Eur Respir J. 2017;50(1):1700094. https://doi.org/10.1183/13993003.00094-2017
  41. Bertoletti L. The paradoxical association between pulmonary embolism and COPD. Eur Respir J. 2017;50(1):1700959. https://doi.org/10.1183/13993003.00959-2017
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