Pulmonary artery thrombosis: strategy of anticoagulation

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This review is devoted to the management of primary artery thrombosis (PAT). This disease was always considered only as a part of other venous thromboembolic events, in particular isolated pulmonary embolism (PE). Various studies show that PAT can develop as an independent event without concomitant damage to extra-vessels. PAT is characterized by own typical signs as primary and recurrent event that can determine special strategies of treatment. However, there are no studies devoted to this problem. We can only make some assumptions about PAT anticoagulation (AC) considering data on isolated PE comprising PAT. These data are available in PADIS-PE, ASPIRE, EINSTEIN-PE, Hokusai-VTE studies underlying modern guidelines of various societies. In the absence of studies on PAT AC these guidelines should regulate PAT AC approaches. AC is recommended in all cases of PE except isolated subsegmental PAT in ambulatory patients. Duration of AC depends on risk factors (major or minor). Anticoagulation for PAT following chronic inflammatory diseases is still disputable.

Keywords:

pulmonary artery thrombosis

pulmonary embolism

anticoagulation

direct oral anticoagulants

Authors:

Porembskaya O.Ya.

Mechnikov North-Western State Medical University;
Institute of Experimental Medicine

SPIN RSCI: 9775-1057
Scopus AuthorID: 56743328700
ORCID: 0000-0003-3537-7409

Kravchuk V.N.

Mechnikov North-Western State Medical University;
Kirov Military Medical Academy

Lobastov K.V.

Pirogov Russian National Research Medical University

ORCID: 0000-0002-5358-7218

Kuzmina-Krutetskaya S.R.

Mechnikov North-Western State Medical University

Laberko L.A.

Pirogov Russian National Research Medical University

Chesnokov M.Sh.

Mechnikov North-Western State Medical University

Velikanova K.E.

Mechnikov North-Western State Medical University

Saiganov S.A.

Mechnikov North-Western State Medical University

Received:

28.12.2020

Accepted:

02.03.2021

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