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Lyadov V.K.

Clinical Oncology Hospital No. 1

Garipov M.R.

Clinical Oncology Hospital No. 1

Polushkin V.G.

Moscow Center of Rehabilitation Treatment LLC

Tarasov N.A.

Republican Clinical Oncology Center

Ayupov R.T.

Republican Clinical Oncology Center

Feoktistov D.V.

Republican Clinical Oncology Center

C-reactive protein as early predictor of anastomotic leakage after surgery for colorectal cancer. Systematic review and meta-analysis

Authors:

Lyadov V.K., Garipov M.R., Polushkin V.G., Tarasov N.A., Ayupov R.T., Feoktistov D.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(8): 82‑87

DOI: 10.17116/hirurgia202008182

Read: 4509 times

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Table of contents

C-REACTIVE PROTEIN AS EARLY PREDICTOR OF ANASTOMOTIC LEAKAGE AFTER SURGERY FOR COLORECTAL CANCER. SYSTEMATIC REVIEW AND META-ANALYSIS
C-REACTIVE PROTEIN AS EARLY PREDICTOR OF ANASTOMOTIC LEAKAGE AFTER SURGERY FOR COLORECTAL CANCER. SYSTEMATIC REVIEW AND META-ANALYSIS

To cite this article:

Lyadov VK, Garipov MR, Polushkin VG, Tarasov NA, Ayupov RT, Feoktistov DV. C-reactive protein as early predictor of anastomotic leakage after surgery for colorectal cancer. Systematic review and meta-analysis. Pirogov Russian Journal of Surgery. 2020;(8):82‑87. (In Russ.)
https://doi.org/10.17116/hirurgia202008182

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

Systematic review and meta-analysis of data on C-reactive protein (CRP) as a predictor of anastomotic leakage (AL) after surgery for colorectal cancer.

MATERIAL AND METHODS

Literature searching was performed in Medline, Elibrary, Scopus, Web of Science databases. Literature request consisted of keywords «CRP», «colorectal surgery», «anastomotic leakage» for the period 2008—2018. Meta-analysis included 2 manuscripts for the second postoperative day, 7 articles for the third postoperative day and 6 articles for the fourth postoperative day. ROC-analysis was made to determine optimal prognostic values.

RESULTS

ROC-curve for the second postoperative day — AUC 0.758; optimal CRP value — 154 mg/l (sensitivity 70.1%, specificity 55.6%), 95% confidence interval 0.698—0.819. ROC-curve for the third postoperative day — AUC 0.715; optimal CRP value — 144.5 mg/l (sensitivity 79.1% specificity 60.3%), 95% confidence interval 0.68—0.75. ROC-curve for the fourth postoperative day — AUC 0.767; optimal CRP value — 122.91 mg/l (sensitivity 72.3% specificity 60%), 95% confidence interval 0.73—0.804.

CONCLUSION

Increased CRP is an early predictor of AL after surgery for colorectal cancer. CRP level ≥144.5 mg/l on the third postoperative day can predict AL (sensitivity 79%, specificity 60%).

Keywords:

C-reactive protein
colorectal cancer
anastomotic leakage

Authors:

Lyadov V.K.

Clinical Oncology Hospital No. 1

Garipov M.R.

Clinical Oncology Hospital No. 1

Polushkin V.G.

Moscow Center of Rehabilitation Treatment LLC

Tarasov N.A.

Republican Clinical Oncology Center

Ayupov R.T.

Republican Clinical Oncology Center

Feoktistov D.V.

Republican Clinical Oncology Center

Received:

03.10.2019

Accepted:

05.11.2019

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