Objective. To compare the results of open and laparoscopic interventions for PGDU complicated by advanced peritonitis. Material and methods. A retrospective analysis enrolled 172 patients with PGDU who underwent surgery for the period 2014—2016. The research was performed at the bases of the Department of Faculty-Based Surgery No. 1 of the Medical Faculty of the Pirogov Russian National Research Medical University. Further analysis enrolled 138 patients in accordance with inclusion and exclusion criteria (laparoscopic intervention — 116 patients, open surgery — 22). Propensity score matching (pseudorandomization) was applied after comparative analysis of patients’ characteristics and treatment outcomes in order to ensure maximum comparability of both groups. Results. Length of hospital-stay (7.1 vs. 9.8 days), incidence of extra-abdominal complications (6.3%. vs. 41.2%) and adverse events Clavien—Dindo grade II (6.3% vs. 35.3%) were significantly lower after minimally invasive surgery (p<0.05). Conclusion. Analysis of comparable groups of patients with PGDU complicated by peritonitis revealed that laparoscopic surgery is accompanied by significantly lower incidence of extra-abdominal postoperative complications and shorter hospital-stay compared with open surgery. Mortality and incidence of intra-abdominal postoperative complications were similar in both groups.